The Grizzly, January 24, 1995

Ursinus College and the U.S. News and World Report Rating System • Ursinus Concludes The Next Step Campaign • 4,000 Casualties in Japanese Earthquake • Newt Confronts Ethics Issues • Local Bank Robber Brought Up on Federal Charges • Politics Department Update • Servant-Leadership Program Comes to Ursinus • St. Andrew\u27s Society of Philadelphia Scholarships • An Afternoon with Picasso and Moore • Thirdgill Kicks Off This Semester\u27s Comedy • Star Trek: Voyager Launches • Support Your Coffee House • Not-So-Super Super Bowl • Alumnus Expresses Concern Over Oversight • Men\u27s B-Ball Snaps Two-Game Skid • Bears Ready For Conference Showdown with Muhlenberg • Gymnasts Off to a Raging Start • Bears Win Triangular Meet • Aqua Bears Swept by Gettysburg • Lady Bears are Ranked For the First Timehttps://digitalcommons.ursinus.edu/grizzlynews/1350/thumbnail.jp

The Grizzly, April 11, 1995

ProTheatre Stages Our Country\u27s Good • Congratulations to the New Phi Beta Kappa Members • Letter to the Editor: Where Have All Our Leaders Gone?; Gay Rights at Ursinus • Quiet Please! • Hello, This is the Phone Mail System • Why Examine Curriculum? • Student Exhibition to Open April 25 • Course Preview: Women in Politics • Final Exam Schedule • Environmental Club Activities Planned to Commemorate Earth Day • Alumnae Spotlight: Kim Caffey • Baseball Team Earns Big Win Over Hopkins • Men\u27s Tennis Gets First Win • Golfers Placed Second at Gettysburg • Women\u27s Tennis Looking for First Win • Trecroce Keys Ursinus Sweep as Softball Team Stays in the Race • Kiwak Named Player of the Week • Landis Named Player of the Week • Cosgrove Honored • Lacrosse Unbeaten in Conference Playhttps://digitalcommons.ursinus.edu/grizzlynews/1359/thumbnail.jp

The Grizzly, September 27, 1994

Berry\u27s Political Future Uncertain • Violence in Haiti Will Not be Tolerated • Status of Citizenship Questioned • What is Newman Society? • On Being Reared in the U.S. • What Scares Me • Rabinor Opens Lectures on Eating Disorders • UC Volleyball Battles Floor Problems and Injuries • UC X-C Runners are New and Improved • Defense to do it for Eagles • Bears Drop Close One to Western Marylandhttps://digitalcommons.ursinus.edu/grizzlynews/1341/thumbnail.jp

The Grizzly, October 25, 1994

Service: It\u27s Not Greek to Them • Ursinus Cross Country Team Involved in Accident • Five Lives Claimed at Bloomsburg Frat House • Pi Omega Delta Captures Banner for Blood Drive • Democrats in Danger: Election for House and Senate too Close to Call • United States and North Korean Timetable for Nuclear Disarmament • Freshman Class Officers Ready to Make a Difference • Lopate Shares Humor and Insight • Berman Museum Celebrates its Fifth Anniversary • Choir to Sing on Saturday • An Open Letter to All Greeks • Basketball Woes • A Few Inches From Drowning • A Philly Fan • UC Soccer Gets Back on Track • Intramural Updatehttps://digitalcommons.ursinus.edu/grizzlynews/1344/thumbnail.jp

The Grizzly, September 21, 1993

Israel and PLO Reach Peace Agreement • The Quilt: To Remember, To Educate, To Celebrate • Russian TV Crew Filming at Ursinus • New Reimert Policies for \u2793-\u2794 • Jurassic Park: It\u27s Only a Movie • Bernie Bernie Headflap Wins the Battle Again! • The Newly Roomie Game • A Unique Affair Awaits Us: Javapalooza \u2793 to Entertain Ursinus • Ursinus Needs AIDS Policy • More Than a Number • The New Wismer? Or a Police State? • Field Hockey Struggles Early • Men\u27s X-Country Starts off 2-0 • Lady Bears Search for Consistencyhttps://digitalcommons.ursinus.edu/grizzlynews/1318/thumbnail.jp

The N-terminus of IpaB provides a potential anchor to the Shigella type III secretion system tip complex protein IpaD

The type III secretion system (T3SS) is an essential virulence factor for Shigella flexneri, providing a conduit through which host-altering effectors are injected directly into a host cell to promote uptake. The type III secretion apparatus (T3SA) is comprised of a basal body, external needle, and regulatory tip complex. The nascent needle is a polymer of MxiH capped by a pentamer of invasion plasmid antigen D (IpaD). Exposure to bile salts (e.g. deoxycholate) causes a conformational change in IpaD and promotes recruitment of IpaB to the needle tip. It has been proposed that IpaB senses contact with host cell membranes, recruiting IpaC and inducing full secretion of T3SS effectors. While the steps of T3SA maturation and their external triggers have been identified, details of specific protein interactions and mechanisms have remained difficult to study due to the hydrophobic nature of the IpaB and IpaC translocator proteins. Here we explored the ability for a series of soluble N-terminal IpaB peptides to interact with IpaD. We found that DOC is required for the interaction and that a region of IpaB between residues 11–27 is required for maximum binding, which was confirmed in vivo. Furthermore, intramolecular FRET measurements indicated that movement of the IpaD distal domain away from the protein core accompanied the binding of IpaB11-226. Together these new findings provide important new insight into the interactions and potential mechanisms that define the maturation of the Shigella T3SA needle tip complex and provide a foundation for further studies probing T3SS activation

A quantified triple bottom line for tourism: experimental results

The tradition of tourism businesses and regional tourism industries is to measure their value to the host community by jobs, wages and tax revenues even though every member of that community is impacted on a daily basis though a broad variety of impacts. This paper demonstrates a conceptual approach for measuring the relative importance of the major dimensions of community quality of life that can be influenced by the tourism industry in order to calculate an indication of overall impact on the well being of community residents. Furthermore, we have formulated a conjoint model that values this overall performance in monetary units. A conjoint model for estimating importance is successfully implemented using samples of college students and tourism industry professionals in the US and Cyprus. A monetary version of Triple Bottom Line impacts is calculated for the impacts of a specific hypothetical tourism business development