2020-05-08 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: UNM drug repurposing. NM cases. Doctors Without Borders. SNAP benefits online. NM 7th highest unemployment. Virtual LemonAid tonight. New N98 masks. Healthcare supply chain challenge. EMS lack resources. Infection risk in healthcare workers. COVID-19 on medical education. Human disinfectant chambers. Evidence of seroconversion. Dangers of considering herd immunity. Wastewater-based surveillance. More youths infected. Reconstructing ship spread. Pharmacoepidemiologic analysis. Clinicopathologic characteristics. Cancer treatment impact. Reduced voluntary psychiatric admission in Italy. Operating room management. Humidifiers reduce transmission. Phone contact tracing ethics. Call for patient database. Immunity certification program. Guidelines on tracheostomy, IBD, nose bleeding, pituitary tumors, and hematopoietic stem cells transplantation, benefits of low-PEEP, and of molecular diagnostics. FDA authorizes at-home test. Cephid Xpert test. MRSA nasal swabs. NIH remdesivir+barictinib RCT. Corticosteroid caution. Arbidol active in vitro. ACE/ARB systematic review. In silico phytochemical and virus protease candidates. Potential zinc benefit. 31 new clinical trials. Glycemic control benefit. Psychological effects meta-analysis and survey. Disease course model. Liver injury. Environmental and health perspectives. Olfactory and gustatory dysfunction. Vitamin D. Disease map

2020-04-30 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM residential facility deaths. NM case update. NM TriCore testing antibodies. Navajo nation cases. May 10 Navajo peak. Udall funding push. El Paso shopping discouraged. NM budget shortfall. Santa Fe furlough. Ethanol sanitizer safety. LA free testing for all. Michigan protest. NM Batelle N95 decontamination. Hospital revenue decline. Wastewater early detection. German herd immunity. 60-day viral shedding possible. Temporary infected “ark”. Prison release preparedness. Low quality research. Phased long-term care. Suicide prevention. Corticosteroid tradeoffs. Cloth mask guidelines. SARS-CoV-2 assays compared. IgG and viral loads. Better testing reporting. Dubious testing vendors. Promising oral drug. Hydroxychloroquine prophylaxis dosing. Umifenovir ineffective. Multi-drug nanoparticles. Drug discovery new targets. 38 new COVID-19 trials. Cancer research review. Attenuated SARS-CoV-2

2020-05-14 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM restrictions loosen. NM case count. Navajo Nation case count. 9 state parks open. Sunport revenue loss. Trump projects vaccine delivery. Wisconsin court case. Smokers quit. Ireland reopening. Danish schools open. Philippine typhoon evacuation. PPE-induced pressure injuries and facial dermatoses. U.S. mask stockpile. PPE for surgeons. Intubation time with aerosol box. Consumer spending with social restrictions. Suicide increase expected. Undetected virus homeless. Chinese infection control. 5% Spain infected. Sanitizing booth. Healthcare worker infection routes. Kawasaki disease France. CDC Kawaski guidance. Italian deaths characterized. CDC reopening school guidance. COVID-19 and epistemology. Monitoring misleading claims. UN mental health policy brief. CDC vaccination schedules. Guidelines on managing endoscopy units. COVID-19 lab testing (for lab professionals). Cancer surgery triage. Operating room practices. Orthodontic treatment. 3D printed NP swabs effective. Salt-water irrigation reduces duration. Corticosteroids ineffectual. Vaccines require biomanufacturing infrastructure. French pharm giant promises fair vaccine distribution. 26 new trials registered. LDH, lymphocytes and hs-CRP predict mortality. Fibrinogen higher in SARS. Insulin resistance. Glycemic monitoring. Hemostasis abnormalities. New phobia scale. OR global consensus. Inpatient cognitive assessments are challenging. Loud speech increases transmission. Monkeys present similarly. Human-to-dog transmission. Cat transmission

2020-04-25/26 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM and Navajo Nation case reports. NM unemployment assistance. Mount Sinai experience. NYC antibody testing starts. US states reopening. US hospitals closure risk. UK universal weekly testing. Russia holiday spikes. Assessments of double-layered cloth masks. Microwave steam disinfection. N95 reuse. Ophthalmic equipment shields. Phased reopening. Inverse quarantine. Low GI endoscopy transmission. Nursing facility transmission. Predicting per-state cases. Forecasting hospital demand. Ventilator triage policies. CDC/OSHA meat processing. Antivirals and DOACs. Thrombotic ultrasound screening. Thromboembolic complications. CT findings reporting. Nasal cannulas over ventilators. Safe intubation/extubation. Convalescent plasma eligibility. Safe ultrasound. Invasive cardiac electrophysiology. Esophageal oncologic surgery. Mental health COPD. Antibody testing controversy. Combined antibody tests better. Immune response and severity. Abbott testing compared. New IgG test. Clinical trials dashboard. No extra ACEI/ARB risk. HCQ G6PD deficiency risk. High HCQ dose risk. Drug discovery review. Estrogen therapy hypothesis. Tocilizumab Tx proposed. Healthcare worker symptoms. Distinguishing CT features. Kidney tissue invasion. Pathophysiology review. T-cell response severity. Caucasian coagulopathy. CDC updates symptom list

2020-05-09/10 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM gets remdesivir. NM case update. Dental services resume. NM prison testing. Educator age risk. Stuart Kauffman dashboard. Long-term care fatalities. Fauci in quarantine. US farmer support. US vaccinations down. South Korea bar shutdown. German rebound lockdown easing. Managing glove skin reactions. Neurosurgery down 70%. Impact airline travel ban. CDC meat packing report. UK distancing impact. 9-day incubation. Low fatality rate estimates. Improving social connection. Social distancing and mask use effective. Parents under stress. Nurse psychological stress. Israel Internal Medicine Tx strategies. Education management. Recommendations are given on endoscopy procedures, management of adrenal insufficiency and of IBD, on re-introduction of cardiovascular services, and respiratory PPE for healthcare workers. Guidelines for medical examiners, coroners, and pathologists. Successful GI department re-opening in China. FDA: serology testing performance. First antigen test approved. FFPE SARS-CoV-2 detection. Triple antiviral therapy effective. Respiratory rehabilitation effective. Targeting inflammatory cascade. Negative HCQ observational study. Chloroquine G6PD risk. Interferon inhibits replication – mouse. Tocilizumab benefit: uncontrolled study. Most trials in HCQ, remdesivir. NKG2A treatment target. In silico antiviral peptides. Chinese medicine review. Cell entry mechanisms. Olfactory viral entry. Higher female immune response. Immune checkpoints. Metagenomic analysis. ¼ hospitalized no risk factors. High RDW mortality. Mortality: vitamin D. Deaths of despair. Optimism and exercise

2020-04-29 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM cases. NM coronavirus origins. Governor update tomorrow. Temporary drivers licenses. Negative tracing app sentiment. CA reopening plans. US travel screening. Influenza reductions w/COVID control. German flu vaccine prep. 1.5B jobs at risk. National health expenditures. US economy shrinks. Aerosolized virus in hospitals. Cellphone disease spread prediction. Social distancing study. Isolation policy effectiveness. Contact tracing to end AIDS/HIV. Homeless shelter prevalence. Predicting herd immunity. Cooler temperatures reduce transmission. NEJM rationing rationalization. ECMO regional planning. Canadian ECMO prioritization. Healthcare worker mental health. Infectious Diseases Society guidelines. US hospitalist guide. Managing pregnancies. Coagulopathy management. Hysteroscopy consensus. Renal transplant immunosuppression. Two RT-PCR alternatives. Remdesivir RCT success. Novaferon promising study. Probiotics evidence summary. Tocilzumab rationale. 53 new clinical trials. Continue ACE use. Coagulopathy risk screening. Liver tests predict progression. Stem-cell organoid model. Phylogenetic network analysis. Severity: innate vs. adaptive immunity. ECMO update

2020-05-06 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM COVID case update. Temporary hospitals for non-COVID patients. Mandatory face coverings for businesses. NM income shortfall. Potential $2 billion NM budget deficit. Relief fund for rural health care providers. Meals for children, seniors, and tribal members. National parks phased reopening. Rural hunger program. Bangladesh to make remdesivir. Healthcare worker infections. Indian police force infections. Shanghai Disneyland reopens. Mask diaper linings. Mask/respirator review. Hospitals need bailouts. Provider financial resources. African lockdown hunger. Virus jumped late 2019. Mortality rates decrease. Early case in France. International reopening recommendations. WHO: don’t rush reopening. CDC: prison management. Timing important. Dedicated COVID-19 facility. Guidelines for: maternal-fetal medicine, neurosurgery, long-QT treatment, gastroenterology. UK testing in low demand. HIV screening efforts continued. Inactivated vaccine candidate. Natural products. Convalescent plasma effectiveness. Clinical trial tracker. 47 new trials. Children couch potatoes. Adolescents troubled. Climate effects deaths. Lupus anticoagulant. Shock in children. Intestinal viral replication. Tocilizumab patient recovery. Protein target. Genomic diversity

2020-05-07 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM cases. Gallup shutdown extended. Gallup hospital crisis. NM assisted living testing. University student financial relief. FDA fraudulent products. Trump/Pence test negative. India displaced repatriated. Use facemasks. Facemasks cause skin damage. PPE protocol. Michigan reopens. Illegal drug prices up. Failing masks from China. Distribution of remdesivir. CDC PPE video. Low German R0. Stay-at-home lowers Rt. Detention facility epidemiology. Saliva transmission. Healthcare informatics shortcomings. Resource allocation ethics. Uninsured drug discounts. Safer food delivery. Bat coronavirus grant axed. Dispelling common misinformation. Recommendations on managing cardiac arrest, cardiac electrotherapy and electrophysiology, hematologic malignancy, ophthalmologic screening and procedures, the use of ACEIs and ARBs. Post-COVID-19 rehabilitation. Hearing problems in children. Resuming orthopedic surgeries. NM prison testing. Qatar 0.07% mortality. Testing manufacturer nontransparency. Understanding RT-PCR vs. ELISA. Influenza infection control surrogate. 24 FDA drugs in vitro activity. NEJM hydroxychloroquine observational study. Monoclonal antibody in vitro. Lysosomal SARS-CoV-2 insights. Chloropromazine inhibits replication. Avoid HCQ in schizophrenia. Alkaloid/terpenoid protease inhibitors. Virus vaccine engineering. GSK otilimab trial. 38 new clinical trials. Virus persistence times. Outcomes for sickle cell and cancer patients. High risk thrombosis. Olfactory dysfunction. Pneumonia vs ARDS. Adapting sacubitril/valsartan. Blood thinners. Mouse study sheds light

2020-04-28 DAILY UNM GLOBAL HEALTH COVID-19 BRIEFING

Executive Summary: NM case update. NM antibody testing. Las Cruces essential worker screening. Small business closure inequity. More jobless benefits. Santa Fe furloughs. NM Funeral homes prepared. NM oil sector hit. State-by-state restrictions/reopenings. US testing expansion. JAMA on prisons. NY reopening focus. Farmers euthanizing animals. New Zealand success. Stockholm herd immunity. UK worst-hit in Europe. Japanese island lockdown. Spain multi-phase plan. Economic damage lockdown duration. Oil price impacts. Aerosol intubation box. Family cluster transmission. US contact tracing lacking. Chinese tracing system. Early US deaths undercounted. More poison center calls. Homeless shelter infection. Reduced coronary syndrome admissions. Italian predicted model. GIS spatial modeling. Exit strategy schemes. Reopening public buildings. Preventive health screening declines. Stress prevention on return to work. Mental health consequences. Protecting healthcare worker well-being. Mental health training lacking. Hospital toilet viral hotspot. Mobile phone tracking. Creating equitable society. Prone positioning protocol. Negative-pressure tracheostomy. Glucocorticoids adrenal insufficiency. ICU team models. Healthcare worker grief. Conducting clinical trials. UK home-care testing. Dry swabbing. ACE inhibitor benefits. 90 vaccines in development. Heparin and thrombocytopenia. 53 clinical trials registered. Respirator comparison. SARS-coV-2 genetic diversity. Transmission with temperature. Antibody dynamics. Vitamin D and severity. Immunosuppression and severity. Temporal artery thermometers low sensitivity. Digestive symptoms and hospitalization