Association between maternal haemoglobin concentrations and maternal and neonatal outcomes: the prospective, observational, multinational, INTERBIO-21st fetal study

Background: Anaemia in pregnancy is a global health problem with associated maternal and neonatal morbidity and mortality. We aimed to investigate the association between maternal haemoglobin concentrations during pregnancy and the risk of adverse maternal and neonatal outcomes. Methods: In this prospective, observational, multinational, INTERBIO-21st fetal study conducted at maternity units in Brazil, Kenya, Pakistan, South Africa, and the UK, we enrolled pregnant women (aged ≥18 years, BMI <35 kg/m2, natural conception, and singleton pregnancy) who initiated antenatal care before 14 weeks' gestation. At each 5±1 weekly visit until delivery, information was collected about the pregnancy, as well as the results of blood tests taken as part of routine antenatal care, including haemoglobin values. The outcome measures were maternal (gestational diabetes, pregnancy-induced hypertension, and preterm premature rupture of membranes) and neonatal outcomes (small for gestational age, preterm birth, and acute respiratory distress syndrome). Findings: Between Feb 8, 2012, and Nov 30, 2019, 2069 women (mean age 30·7 years [SD 5·0]) had at least one routinely haemoglobin concentration measured at 14–40 weeks' gestation, contributing 4690 haemoglobin measurements for the analysis. Compared with a haemoglobin cutoff of 110 g/L, the risk was increased more than two-fold for pregnancy-induced hypertension at haemoglobin concentrations of 170 g/L (risk ratio [RR] 2·29 [95% CI 1·19–4·39]) and higher, for preterm birth at haemoglobin concentrations of 70 g/L (RR 2·04 [95% CI 1·20–3·48]) and 165 g/L (RR 2·06 [95% CI 1·41–3·02]), and for acute respiratory distress syndrome at haemoglobin concentrations of 165 g/L (RR 2·84 [95% CI 1·51–5·35]). Trimester-specific results are also presented. Interpretation: Our data suggests that the current WHO haemoglobin cutoffs are associated with reduced risk of adverse maternal and neonatal outcomes. The current haemoglobin concentration cutoffs during pregnancy should not only consider thresholds for low haemoglobin concentrations that are associated with adverse outcomes but also define a threshold for high haemoglobin concentrations given the U-shaped relationship between haemoglobin concentration and adverse neonatal and maternal outcomes

Burnout among caregivers in the Yaounde Central Hospital, Cameroon

INTRODUCTION : le burnout ou syndrome d'épuisement professionnel des soignants est un problème de santé publique au Cameroun. Il se manifeste par un épuisement émotionnel, une dépersonnalisation et une diminution de l'accomplissement personnel du sujet. Il touche la plupart des personnels soignants et les conséquences sont nombreuses. Au Cameroun en général et à l'Hôpital Central de Yaoundé (HCY) en particulier, toutes ces dernières années, les soignants n'ont cessés d'exprimer leur mécontentement face à leurs conditions de travail à travers des grèves et menaces de divers ordres. La prise en charge des patients se fait de façon impersonnelle et on assiste à des conséquences dramatiques et des problèmes déontologiques. METHODES : notre étude transversale analytique avait pour objectif de déterminer les facteurs qui sont associés au burnout dans cette population des soignants de l'HCY. Pour ce faire, pendant un mois, nous avons administré auprès de ces soignants notre questionnaire conçu selon les modèles théoriques de Maslach et Siegrist. Nous avons pu obtenir des informations recherchées auprès de 104 personnels soignants; la saisie et l'analyse des données se sont faites avec SPSS 20. RESULTATS : les résultats montrent auprès des soignants de quatre unités de soins de l'HCY des manifestations similaires à celles trouvées dans la littérature et une prévalence du Burnout (BO) de 63% parmi ces soignants. Sept facteurs y ont été associés de façon statistiquement significative: il s'agit du pavillon d'exercice (OR= 3.93; 1.16-13.24; p-value=0.027); le statut matrimonial (OR: 2.56; 1.22 - 5.39; p-value=0,049); le ratio effort/récompenses déséquilibré (OR: 2.31; 1.10 - 4.84; p-value=0.026 ); avoir été menacé physiquement ou verbalement (OR: 3,75; 1,49 - 9,41; 0,005); le maintien de l'équilibre entre vie privée et vie professionnelle (OR: 3,41; 1,19- 10,7; p-value=0,038); la fréquence des oublis (OR: 4,25 -1,33; 7,91; p-value=0,002) l'attribution des erreurs aux conditions de travail (OR: 2,05;1,52 - 24,0; p-value=0,011). CONCLUSION : le burnout est présent au sein des populations soignantes de l'HCY et risque de s'accroitre si rien n'est fait. Des stratégies de prévention et de promotion de la santé au travail sont vivement nécessaires dans les aspects de l'amélioration des conditions de travail; les prises de bonnes décisions politique et managériales; l'amélioration des relations entre soignants et soignant-hiérarchie et la recherche constante, le suivi et contrôle des facteurs de risque.INTRODUCTION : burnout or burnout syndrome is a public health problem in Cameroon. It manifests itself by emotional exhaustion, depersonalization, and diminished personal accomplishment of the subject. It affects most healthcare workers (HCW) and the consequences are numerous. In Cameroon in general, and Yaounde Central Hospital (HCY) in particular, in recent years, healthcare workers have continued to express dissatisfaction with their working conditions through strikes and threats of various kinds. The care of patients is suboptimal with sometimes dramatic consequences and ethical concerns. METHODS : our cross-sectional study aimed to determine the factors that are associated with burnout among healthcare personnel (HCW) of HCY. To do this, for one month, we administered to these HCWs our questionnaire designed according to the theoretical models of MASLACH and SIEGRIST. We were able to obtain information from 104 caregivers; data entry and analysis was done with SPSS 20. RESULTS : the results show that HCWs of four departments of HCY have similar manifestations to those found in the literature and the prevalence of burnout syndrome amon HCWs of HCY was 63%. Seven factors were statistically significantly associated with burnout syndrome among HCWs in HCY: the department (care unit) the HCW was assigned to (OR = 3.93, 1.16-13.24, p-value = 0.027); marital status (OR: 2.56, 1.22 - 5.39, p-value = 0.049); the effort-reward imbalance (OR: 2.31, 1.10 - 4.84, p-value = 0.026); having received been threatened physically or verbally (OR: 3.75, 1.49 - 9.41, 0.005); maintaining the balance between private and professional life (OR: 3.41, 1.19- 10.7, p-value = 0.038); frequency of forgetfulness (OR: 4.25 -1.33, 7.91, p-value = 0.002) and attribution of errors to working conditions (OR: 2.05, 1.52 - 24.0; -value = 0.011). CONCLUSION : burnout is common among HCWs of HCY and is likely to keep increasing if nothing is done. Prevention and promotion strategies for occupat ional health are strongly needed in aspects of improving working conditions; making good political and managerial decisions; improving relationships between caregivers and caregivers-hierarchy and constant research, monitoring and control of risk factors.http://www.panafrican-med-journal.comam2020School of Health Systems and Public Health (SHSPH