Diseño de un sistema de información administrativo contable para un ente sin fines de lucro

El análisis de riesgos y como las organizaciones los enfrentan, ayuda a que las mismas puedan alcanzar los objetivos que se propongan de forma eficaz y eficiente. La mencionada perspectiva, implica un cambio proactivo de las organizaciones, entendiendo cuáles son los eventos que las afectan y de qué manera generan mecanismos para enfrentarlos (riesgos) y aprovecharlos (oportunidades). El presente trabajo aborda el estudio del caso particular del área de Tesorería de un Sindicato del medio, donde a partir del estudio de los riesgos asociados, sus características actuales y bajo la perspectiva del Informe COSO, se proponen herramientas administrativas a fin de mejorar el proceso de gestión en el mencionado sector. Se realiza una investigación cualitativa, a través de la metodología de diseño no experimental, descriptivo, bibliográfico, documental y de caso. Se aplica la técnica de entrevista y observación directa. Para recolectar la información se hace uso de la revisión bibliográfica y documental. La investigación se inicia como búsqueda de soluciones a un ente sin fines de lucro, en particular, pero que puede ser aplicable a otros entes de cualquier envergadura con sedes o sucursales, como así también negocios pequeños que inician y requieren necesidades de información de fácil adaptación. El trabajo concluye con el cumplimiento de los objetivos propuestos al inicio del mismo al poder dotar al ente bajo análisis de nuevas herramientas administrativas y concientizar a los miembros del mismo sobre los riesgos del área de tesorería.Fil: Abayay, Cristian Nicolás. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.Fil: Estudillo, Alejandro Miguel. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas.Fil: Mengoni, Pablo Enrique. Universidad Nacional de Cuyo. Facultad de Ciencias Económicas

Polarization modulation instability in all-normal dispersion microstructured optical fibers with quasi-continuous pump

We report the experimental observation of the polarization modulation instability (PMI) effect in all-normal dispersion (ANDi)microstructured optical fibers (MOFs) with quasicontinuous pumping. The small unintentional birefringence (∼10−5), that any realistic nonpolarization maintaining MOF exhibits, contributes to this nonlinear effect. PMI can produce two sidebands whose polarization state is orthogonal to the polarization of the pump. In this work, only one type of PMI process is observed, i.e., when the pump is polarized along the slow axis of the fiber and sidebands are generated in the fast axis mode. This PMI process was studied experimentally in two ANDi fibers with different dispersion features and pumped with long (700 ps) pump pulses at 1064 nm. Experimental results are compared with theoretical calculations, with reasonably good agreement

Propuesta de mejora en el proceso de inscripción de la Universidad Pedagógica Veracruzana Centro Xalapa

Objetivo general: Diseñar un manual de procedimientos para contribuir a la eficiente ejecución de las actividades que conforman el proceso de inscripción de los alumnos de la Universidad Pedagógica Veracruzana Centro Xalapa

Cryopreservation of Gametes and Embryos and Their Molecular Changes

The process of freezing cells or tissues and depositing them in liquid nitrogen at –196 °C is called cryopreservation. Sub-zero temperature is not a physiological condition for cells and water ice crystals represent the main problem since they induce cell death, principally in large cells like oocytes, which have a meiotic spindle that degenerates during this process. Significantly, cryopreservation represents an option for fertility preservation in patients who develop gonadal failure for any condition and those who want to freeze their germ cells for later use. The possibility of freezing sperm, oocytes, and embryos has been available for a long time, and in 1983 the first birth with thawed oocytes was achieved. From the mid-2000s forward, the use of egg vitrification through intracytoplasmic sperm injection has improved pregnancy rates. Births using assisted reproductive technologies (ART) have some adverse conditions and events. These risks could be associated with ART procedures or related to infertility. Cryopreservation generates changes in the epigenome of gametes and embryos, given that ART occurs when the epigenome is most vulnerable. Furthermore, cryoprotective agents induce alterations in the integrity of germ cells and embryos. Notably, cryopreservation extensively affects cell viability, generates proteomic profile changes, compromises crucial cellular functions, and alters sperm motility. This technique has been widely employed since the 1980s and there is a lack of knowledge about molecular changes. The emerging view is that molecular changes are associated with cryopreservation, affecting metabolism, cytoarchitecture, calcium homeostasis, epigenetic state, and cell survival, which compromise the fertilization in ART

The Impairment of Blood-Brain Barrier in Alzheimer’s Disease: Challenges and Opportunities with Stem Cells

Alzheimer’s disease (AD) is the most common neurodegenerative disorder and its prevalence is increasing. Nowadays, very few drugs effectively reduce AD symptoms and thus, a better understanding of its pathophysiology is vital to design new effective schemes. Presymptomatic neuronal damage caused by the accumulation of Amyloid β peptide and Tau protein abnormalities remains a challenge, despite recent efforts in drug development. Importantly, therapeutic targets, biomarkers, and diagnostic techniques have emerged to detect and treat AD. Of note, the compromised blood-brain barrier (BBB) and peripheral inflammation in AD are becoming more evident, being harmful factors that contribute to the development of the disease. Perspectives from different pre-clinical and clinical studies link peripheral inflammation with the onset and progression of AD. This review aims to analyze the main factors and the contribution of impaired BBB in AD development. Additionally, we describe the potential therapeutic strategies using stem cells for AD treatment

Aryl Hydrocarbon Receptor in Post-Mortem Hippocampus and in Serum from Young, Elder, and Alzheimer’s Patients

One of the characteristics of the cerebral aging process is the presence of chronic inflammation through glial cells, which is particularly significant in neurodegeneration. On the other hand, it has been demonstrated that the aryl hydrocarbon receptor (AHR) participates in the inflammatory response. Currently, evidence in animal models shows that the hallmarks of aging are associated with changes in the AHR levels. However, there is no information concerning the behavior and participation of AHR in the human aging brain or in Alzheimer’s disease (AD). We evaluated the expression of AHR in human hippocampal post-mortem tissue and its association with reactive astrocytes by immunohistochemistry. Besides this, we analyzed through ELISA the AHR levels in blood serum from young and elder participants, and from AD patients. The levels of AHR and glial fibrillar acid protein were higher in elder than in young post-mortem brain samples. AHR was localized mainly in the cytosol of astrocytes and displayed a pattern that resembles extracellular vesicles; this latter feature was more conspicuous in AD subjects. We found higher serum levels of AHR in AD patients than in the other participants. These results suggest that AHR participates in the aging process, and probably in the development of neurodegenerative diseases like AD

Upregulation of S100A8 in peripheral blood mononuclear cells from patients with depression treated with SSRIs: a pilot study

Abstract Background Major depressive disorder (MDD) affects more than 350 million people worldwide, and there is currently no laboratory test to diagnose it. This pilot study aimed to identify potential biomarkers in peripheral blood mononuclear cells (PBMCs) from MDD patients. Methods We used tandem mass tagging coupled to synchronous precursor selection (mass spectrometry) to obtain the differential proteomic profile from a pool of PBMCs from MDD patients and healthy subjects, and quantitative PCR to assess gene expression of differentially expressed proteins (DEPs) of our interest. Results We identified 247 proteins, of which 133 had a fold change ≥ 2.0 compared to healthy volunteers. Using pathway enrichment analysis, we found that some processes, such as platelet degranulation, coagulation, and the inflammatory response, are perturbed in MDD patients. The gene-disease association analysis showed that molecular alterations in PBMCs from MDD patients are associated with cerebral ischemia, vascular disease, thrombosis, acute coronary syndrome, and myocardial ischemia, in addition to other conditions such as inflammation and diabetic retinopathy. Conclusions We confirmed by qRT-PCR that S100A8 is upregulated in PBMCs from MDD patients and thus could be an emerging biomarker of this disorder. This report lays the groundwork for future studies in a broader and more diverse population and contributes to a deeper characterization of MDD

Prognostic Impact of CD36 Immunohistochemical Expression in Patients with Muscle-Invasive Bladder Cancer Treated with Cystectomy and Adjuvant Chemotherapy

Neoadjuvant chemotherapy followed by a cystectomy is the standard treatment in muscle-invasive bladder cancer (MIBC). However, the role of chemotherapy in the adjuvant setting remains controversial, and therefore new prognostic and predictive biomarkers are needed to improve the selection of MIBC patients. While lipid metabolism has been related to several biological processes in many tumours, including bladder cancer, no metabolic biomarkers have been identified as prognostic in routine clinical practice. In this multicentre, retrospective study of 198 patients treated with cystectomy followed by platinum-based adjuvant chemotherapy, we analysed the immunohistochemical expression of CD36 and correlated our findings with clinicopathological characteristics and survival. CD36 immunostaining was positive in 30 patients (15%) and associated with more advanced pathologic stages (pT3b-T4; p = 0.015). Moreover, a trend toward lymph node involvement in CD36-positive tumours, especially in earlier disease stages (pT1-T3; p = 0.101), was also observed. Among patients with tumour progression during the first 12 months after cystectomy, disease-free survival was shorter in CD36-positive tumours than in those CD36-negative (6.51 months (95% CI 5.05–7.96) vs. 8.74 months (95% CI 8.16–9.32); p = 0.049). Our results suggest an association between CD36 immunopositivity and more aggressive features of MIBC and lead us to suggest that CD36 could well be a useful prognostic marker in MIBC