46 research outputs found

    Role for p300 in Pax 8 Induction of Thyroperoxidase Gene Expression

    Get PDF
    The nuclear p300 protein functions as a co-activator of gene transcription. Here we show that p300 works as a co-activator of the transcription factor Pax 8 on the thyroperoxidase gene promoter. Consistent with its role as co-activator, p300 potentiates Pax 8-activated transcription. Furthermore, we provide evidence supporting the formation of a complex between both factors in vivo and in vitro. This interaction involves the amino-terminal and CH3 domains of p300 and the trans-activation domain of Pax 8 at its carboxyl-terminal end. We show that the CH3 domain is crucial for the co-activator role of p300 on the thyroperoxidase gene promoter. In agreement with our finding and with the ability of the adenoviral protein E1A to bind p300, we show that E1A down-regulates Pax 8 activity

    Geomorphological map of the Tremiti Islands (Puglia, Southern Adriatic Sea, Italy), scale 1:15,000

    Get PDF
    This paper describes the Geomorphological map of the Tremiti Islands (Puglia, Southern Adriatic Sea, Italy), scale 1:15,000. The Tremiti Islands, located north of Gargano promontory's coast, are part of a complex geological area within the Adriatic basin, facing the junction between the central and southern Apennines. This area is well known for Neogenic-Quaternary stratigraphic, tectonic and seismologic aspects and is crucial for the definition of Late Quaternary Adriatic basin evolution. The map is the result of a geomorphological study carried out on the islands and the inner continental shelf around them. This study incorporates: (1) field recognition of Quaternary continental deposits and geomorphological mapping, supported by radiometric dating, focused on the morpho-lithostratigraphic correlation of deposits among the different islands and the recognition of landforms that controlled landscape evolution; (2) bathymetric analysis; (3) geomorphological analysis of data from a side scan sonar survey, ..

    Geological and geomorphological analysis of a complex landslides system: the case of San Martino sulla Marruccina (Abruzzo, Central Italy)

    Get PDF
    This work deals with the landslides affecting the area surrounding the village of San Martino sulla Marrucina and involving the neighboring municipalities of Casacanditella and Filetto. The geological and geomorphological settings of this area are being discussed. The enclosed maps have been realized following a multidisciplinary approach, based on morphometric, geological, and geomorphological analyses and supported by air-photo interpretation, dendrochronology, and satellite SAR interferometry (InSAR). The map is organized in four sections: orography (on the upper part), geological map (on the upper right part), main geomorphological map (in the central left part, 1:7,500 scale), and multitemporal analysis (in the lower part). The aforementioned multi-temporal assessment of landslides was performed according to the geomorphological evidence-based criteria and the past ground displacement measurements were obtained by dendrochronology and InSAR. The aim of the study is to understand the evolution in time and space of this landslide area, focusing on the corresponding kinematics

    Geological tourist mapping of the Mount Serrone fault Geosite (Gioia dei Marsi, Central Apennines, Italy)

    Get PDF
    © 2019 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group on behalf of Journal of MapsThe Geological tourist map of the Mount Serrone fault Geosite (Gioia dei Marsi, Italy) has been realized for describing, in an educational perspective, the surface expression of one of the main active faults of the Central Apennines, connected with the 1915 Fucino earthquake (magnitude 7, historically, one of the strongest in Italy). The Central Apennines are a mountain range whose landscape is deeply connected to active tectonics and seismicity, as documented by recent earthquakes. In this framework, the map is a useful tool for the dissemination of the geological knowledge of the Fucino area and faults in general and for the promotion of a geological landscape through a modern, sustainable and environmentally aware tourism. The map is double-sided with simple texts and cartoons on the front outlining general info about the geosite, faults and earthquakes, how to behave in seismic areas and historical notes. The back shows the Main Map with its visual legend featuring the main geological and tectonic elements of the Mount Serrone fault Geosite and the long term history of the landscape. Through simple keywords and concepts, tectonics, faults and earthquakes are shown to be natural features that have contributed to shape the landscape of the Apennines over geological time, as well as something to be afraid and worried of, as they are connected to natural hazard and disasters. This approach is aimed at increasing people’s awareness of geological processes and hazards (i.e. seismic), which with adequate knowledge and proper land management, can be lived with.Published298–3092TM. Divulgazione ScientificaJCR Journa

    Long-term geomorphological evolution in the Abruzzo area, Central Italy: twenty years of research

    No full text
    The most recent research studies into the long-term landscape evolution of the Abruzzo area, carried out over the last twenty years at the “G. d’Annunzio” University of Chieti-Pescara, are based on an integrated approach incorporating structural geology and geomorphology and, in particular, the geomorphometry of topographic and hydrographic aspects, geological and structural-geomorphological surveys and mapping supported by morpho-stratigraphic and chronological constraints. The geomorphological analyses have allowed us to outline the main stages of geomorphological evolution and to identify the factors that have contributed to the landscape shaping of the Apennine Chain, the Adriatic Piedmont and the fluvial plains and coastal sectors, up to the Tremiti islands. In the Apennine Chain, landscape evolution — in a ridge, valley and basin system — is connected to the regional uplift, local tectonic subsidence and local base level variations, which have led to changes in the drainage systems, from exoreic to endorheic (in the intermontane basins) and then to exoreic again. In the Adriatic Piedmont, landscape shaping is connected to uplifting and eustatic sea-level fluctuations, which have induced the formation of a structure-controlled drainage system and the shaping of systems of entrenched alluvial fans and large consequent river valleys, with flights of river terraces. In the coastal Adriatic area — composed of a coastal plain-coastal slope system (northern and southern coast) and of a cliffed rocky coast (central coast, Tremiti) interrupted by river valleys — landscape shaping is the result of selective erosion due to the interaction between marine geomorphic processes and slope processes connected to Late Quaternary eustatic fluctuations

    Morphoneotectonics of the Abruzzo Periadriatic Area (Central Italy): Morphometric Analysis and Morphological Evidence of Tectonics Features

    No full text
    Drainage basin-scale morphometric analysis and morphological evidence of tectonics represent helpful tools to evaluate and investigate morphoneotectonic processes in tectonically active regions. In this perspective, we applied an integrated analysis to the Abruzzo Periadriatic Area, between the Tronto and Sinello rivers (Central Italy). It involved morphometric analysis, structural geomorphological field mapping, and detailed analysis of fluvial terraces. Geomorphic indexes and markers (e.g., Irta, SL index, ksn, and knickpoints) were used in this study to detect the response of landscapes to drainage systems’ unsteadiness and tectonic deformation processes, possibly induced by the ongoing activity of the buried tectonic structures. Furthermore, the investigation of morphological field evidence of tectonics, integrated with the analysis of fluvial terraces’ spatial and temporal arrangement, was performed to assign relative, geomorphologically-based, age constraints of the landscape evolution. The resulting data allowed us to define domains affected by different morphostructural and morphoneotectonic processes, related to the impact and ongoing activity of the five detected families of structural elements (S1, F1, F2, F3, and F4), mainly characterized by compressive, extensional, and transtensive kinematics. Finally, this study could represent a scientific basis for integrating morphometric, fluvial, and tectonic geomorphology analysis to better define the main phases of the landscape evolution and the impact of morphoneotectonic processes on fluvial environments in uplifting piedmont areas

    Fluvial dynamics in the Castel di Sangro plain: morphological changes and human impact from 1875 to 1992

    No full text
    In recent years, morphology and hydrogeology of the Castel di Sangro plain have undergone significant man-made changes. The plain is located in a very complex geological area where the Latium-Abruzzi carbonate platform, the Morrone-Rotella-Pizzone carbonate platform and the Molise nappe meet. Hydrology, hydrogeology, morphology and neotectonics of the area are conditioned by interlocking and overlapping of such palaeogeographic units. Some of them can be clearly recognised in the upper and middle Sangro area. After outlining the geological, structural and geomorphological features of the area, the authors discuss the morphological changes which occurred in the Sangro River pattern and its alluvial plain from 1875 to 1992 as a result of construction of major hydraulic structures (dams, river bed cementation, urbanisation of flood plain and spring areas, wells). Elements inferred from comparison of maps and aerial photographs were also considered. The study provides a concise description of objective observations on both natural and man-induced fluvial processes and groundwater flows. (C) 1997 Elsevier Science B.V
    corecore