Dysplastic nevus associated with seborrheic keratosis

Seborrheic keratosis is a common skin lesion which may coincidentally be associated melanocytic nevi. The authors describe a case of dysplastic nevus associated with seborrheic keratosis and discuss the clinical, dermoscopic, and histological findings of this association. They also discuss the association between seborrheic keratosis and other benign and malignant tumours.Federal University of São Paulo Department of DermatologyFederal University of São Paulo Department of PathologyFederal University of São Paulo Departments of Dermatology and PathologyFederal University of São Paulo Departments of DermatologyUNIFESP, Department of DermatologyUNIFESP, Department of PathologyUNIFESP, Departments of Dermatology and PathologyUNIFESP, Departments of DermatologySciEL

Disseminated cryptococcosis with skin lesions: report of a case series

Cryptococcosis is a common fungal infection in immunocompromised patients, caused by genus Cryptococcus, presenting with meningitis, pneumonia, and skin lesions. Cutaneous presentation can be varied, but specifically in solid organ transplant recipients (iatrogenically immunocompromised), cryptococcosis should always be considered in the differential diagnosis of cellulitis-like lesions, since the delay in diagnosis leads to worse prognosis and fatal outcome. We report four cases of cryptococcosis with cutaneous manifestation not only for its rarity, but also to emphasize the important role of the dermatologist in the diagnosis of this disease.Univ Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Dept Pathol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo EPM UNIFESP, Escola Paulista Med, Dept Pathol, Sao Paulo, SP, BrazilWeb of Scienc

Acne arising on a facial Becker nevus following the lines of Blaschko

Univ Fed São Paulo UNIFESP, Escola Paulista Med, Dept Dermatol, São Paulo, SP, BrazilUniv Fed São Paulo UNIFESP, Escola Paulista Med, Dept Pathol, São Paulo, SP, BrazilUniv Fed São Paulo UNIFESP, Escola Paulista Med, Dept Dermatol, São Paulo, SP, BrazilUniv Fed São Paulo UNIFESP, Escola Paulista Med, Dept Pathol, São Paulo, SP, BrazilWeb of Scienc

Melanoma developed during pregnancy - A case report

We describe a case of plantar interdigital cutaneous melanoma in a 22-year-old woman who reported changes in a pigmented lesion during pregnancy. Diagnosis was late and evolution unfavourable. The purpose of this report is to draw the attention of dermatologists to the need for careful regular examination of melanocytic lesions in pregnant women, not ignoring possible changes as always physiological.Universidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Department of DermatologyUniversidade Federal de São Paulo (UNIFESP), Escola Paulista de Medicina (EPM) Departments of Dermatology and PathologyUNIFESP, EPM, Department of DermatologyUNIFESP, EPM, Departments of Dermatology and PathologySciEL

Fabry disease: clinical and genotypic aspects of three cases in first degree relatives

Fabry disease is an X-linked, lysosomal storage disease caused by the inherited deficiency of the enzyme α-galactosidase A. The diagnosis is usually late, with renal, cardiovascular and/or cerebral complications that reduce life expectancy. Angiokeratomas are asymptomatic lesions present as the initial manifestation and usually less appreciated. Their detection is important for early diagnosis and institution of treatment with enzyme replacement therapy, which prevents late complications reducing morbidity and mortality. We report a case of a male teenager with acroparestesias and angiokeratomas. Family medical research discovered that his mother and brother had similar signs and symptoms and that the three patients had the same mutation in the gene encoding the enzyme, confirming the diagnosis.Universidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Dermatology DepartmentUniversidade Federal de São Paulo (UNIFESP) Escola Paulista de Medicina Dermatology and Pathology departmentsUNIFESP, EPM, Dermatology DepartmentUNIFESP, EPM, Dermatology and Pathology departmentsSciEL

Biologic therapy-induced pemphigus

Univ Fed Sao Paulo Unifesp, Dept Dermatol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Dept Pathol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Dept Dermatol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Dept Pathol, Sao Paulo, SP, BrazilWeb of Scienc

Pyoderma gangrenosum associated with left iliac vein compression syndrome: presentation of difficult diagnosis

Pyoderma gangrenosum is a rare neutrophilic dermatosis of unknown etiology, of which the most frequent clinical manifestations are ulcers. The diagnosis difficulty is, among other things, to rule out other causes of ulcers, since it is considered a diagnosis of exclusion. Skin ulcerations may also occur in the iliac vein compression syndrome, which, like pyoderma gangrenosum, mainly affects young women. Because they have such similar characteristics, the presence of vascular disease may hinder the diagnosis of concurrent pyoderma gangrenosum. Because of the clinical relevance of ulcerated lesions and scars, the early diagnosis and treatment of this condition is considered extremely important. We report a case in which the two diseases were associated, hampering the diagnosis of pyoderma gangrenosum.Univ Fed Sao Paulo Unifesp, Sao Paulo, SP, BrazilUniv Fed Sao Paulo EPM Unifesp, Dept Dermatol, Escola Paulista Med, Sao Paulo, SP, BrazilUniv Fed Sao Paulo EPM Unifesp, Dept Dermatol, Outpatient Clin Geriatr Dermatol, Escola Paulista Med, Sao Paulo, SP, BrazilUniv Fed Sao Paulo EPM Unifesp, Dept Pathol, Escola Paulista Med, Sao Paulo, SP, BrazilUniv Fed Sao Paulo Unifesp, Sao Paulo, SP, BrazilUniv Fed Sao Paulo EPM Unifesp, Dept Dermatol, Escola Paulista Med, Sao Paulo, SP, BrazilUniv Fed Sao Paulo EPM Unifesp, Dept Dermatol, Outpatient Clin Geriatr Dermatol, Escola Paulista Med, Sao Paulo, SP, BrazilUniv Fed Sao Paulo EPM Unifesp, Dept Pathol, Escola Paulista Med, Sao Paulo, SP, BrazilWeb of Scienc

Giant atypical lipoma

Liposarcomas correspond to the most common histological subtype of soft tissue sarcomas. They can be subdivided into: well differentiated or atypical lipoma, undifferentiated, myxoid, round, and pleomorphic cells. Atypical lipomas are the most prevalent and usually appear as asymptomatic softened tumors. They are locally aggressive but rarely lead to distant metastases. The diagnosis of this tumor is based on the imaging and histopathologic findings. Treatment consists of excision surgery with complete tumor removal. It has a good prognosis due to the low percentage of distant metastases. We report a rare case of giant atypical lipoma as well as the adopted therapy and evolution.Univ Fed Sao Paulo UNIFESP, Dept Dermatol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo UNIFESP, Dept Pathol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo UNIFESP, Dept Dermatol, Sao Paulo, SP, BrazilUniv Fed Sao Paulo UNIFESP, Dept Pathol, Sao Paulo, SP, BrazilWeb of Scienc