65 research outputs found
A systematic review of cannabidiol dosing in clinical populations
Aims: Cannabidiol is a cannabis-derived medicinal product with potential application in a wide-variety of contexts, however its effective dose in different disease states remains unclear. This review aimed to investigate what doses have been applied in clinical populations, in order to understand the active range of cannabidiol in a variety of medical contexts. Methods: Publications involving administration of cannabidiol alone were collected by searching PubMed, EMBASE and ClinicalTrials.gov. Results: A total of 1038 articles were retrieved, of which 35 studies met inclusion criteria covering 13 medical contexts. 23 studies reported a significant improvement in primary outcomes (e.g. psychotic symptoms, anxiety, seizures), with doses ranging betwee
Application of mineralogical, petrological and geochemical tools for evaluating the palaeohdrogeological evolution of the PADAMOT study sites
The role of Work Package (WP) 2 of the PADAMOT project – ‘Palaeohydrogeological Data
Measurements’ - has been to study late-stage fracture mineral and water samples from
groundwater systems in Spain, Sweden, United Kingdom and the Czech Republic, with the aim
of understanding the recent palaeohydrogeological evolution of these groundwater systems. In
particular, the project sought to develop and evaluate methods for obtaining information about
past groundwater evolution during the Quaternary (about the last 2 million years) by examining
how the late-stage mineralization might record mineralogical, petrographical and geochemical
evidence of how the groundwater system may have responded to past geological and
climatological changes.
Fracture-flow groundwater systems at six European sites were studied:
• Melechov Hill, in the Bohemian Massif of the Czech Republic: a shallow (0-100 m)
dilute groundwater flow system within the near-surface weathering zone in fractured
granitic rocks;
• Cloud Hill, in the English Midlands: a (~100 m) shallow dilute groundwater flow system
in fractured and dolomitized Carboniferous limestone;
• Los Ratones, in southwest Spain: an intermediate depth (0-500 m) dilute groundwater
flow system in fractured granitic rocks;
• Laxemar, in southeast Sweden: a deep (0-1000 m) groundwater flow system in fractured
granitic rocks. This is a complex groundwater system with potential recharge and
flushing by glacial, marine, lacustrine and freshwater during the Quaternary;
• Sellafield, northwest England: a deep (0-2000 m) groundwater flow system in fractured
Ordovician low-grade metamorphosed volcaniclastic rocks and discontinuous
Carboniferous Limestone, overlain by a Permo-Triassic sedimentary sequence with
fracture and matrix porosity. This is a complex coastal groundwater system with deep
hypersaline sedimentary basinal brines, and deep saline groundwaters in crystalline
basement rocks, overlain by a shallow freshwater aquifer system. The site was glaciated
several times during the Quaternary and may have been affected by recharge from glacial
meltwater;
• Dounreay, northeast Scotland: a deep (0-1400 m) groundwater flow system in fractured
Precambrian crystalline basement overlain by fractured Devonian sedimentary rocks.
This is within the coastal discharge area of a complex groundwater system, comprising
deep saline groundwater hosted in crystalline basement, overlain by a fracture-controlled
freshwater sedimentary aquifer system. Like Sellafield, this area experienced glaciation
and may potentially record the impact of glacial meltwater recharge.
In addition, a study has been made of two Quaternary sedimentary sequences in Andalusia in
southeastern Spain to provide a basis of estimating the palaeoclimatic history of the region that
could be used in any reconstruction of the palaeoclimatic history at the Los Ratones site:
• The Cúllar-Baza lacustrine sequence records information about precipitation and
palaeotemperature regimes, derived largely from the analysis of the stable isotope (δ18O
and δ13C) signatures from biogenic calcite (ostracod shells).
• The Padul Peat Bog sequence provided information on past vegetation cover and
palaeogroundwater inputs based on the study of fossil pollen and biomarkers as proxies
for past climate change.
Following on from the earlier EC 4th Framework EQUIP project, the focus of the PADAMOT
studies has been on calcite mineralization. Calcite has been identified as a late stage mineral, closely associated with hydraulically-conductive fractures in the present-day groundwater
systems at the Äspö-Laxemar, Sellafield, Dounreay and Cloud Hill sites. At Los Ratones and
Melechov sites late-stage mineralization is either absent or extremely scarce, and both the
quantity and fine crystal size of any late-stage fracture mineralization relevant to Quaternary
palaeohydrogeological investigations is difficult to work with. The results from the material
investigated during the PADAMOT studies indicate that the fracture fillings at these sites are
related to hydrothermal activity, and so do not have direct relevance as Quaternary indicators.
Neoformed calcite has not been found at these two sites at the present depth of the investigations.
Furthermore, the HCO3
- concentration in all the Los Ratones groundwaters is mainly controlled
by complex carbonate dissolution. The carbonate mineral saturation indices do not indicate
precipitation conditions, and this is consistent with the fact that neoformed calcite, ankerite or
dolomite have not been observed petrographically
Back to the future : using long-term observational and paleo-proxy reconstructions to improve model projections of Antarctic climate
Quantitative estimates of future Antarctic climate change are derived from numerical global climate models. Evaluation of the reliability of climate model projections involves many lines of evidence on past performance combined with knowledge of the processes that need to be represented. Routine model evaluation is mainly based on the modern observational period, which started with the establishment of a network of Antarctic weather stations in 1957/58. This period is too short to evaluate many fundamental aspects of the Antarctic and Southern Ocean climate system, such as decadal-to-century time-scale climate variability and trends. To help address this gap, we present a new evaluation of potential ways in which long-term observational and paleo-proxy reconstructions may be used, with a particular focus on improving projections. A wide range of data sources and time periods is included, ranging from ship observations of the early 20th century to ice core records spanning hundreds to hundreds of thousands of years to sediment records dating back 34 million years. We conclude that paleo-proxy records and long-term observational datasets are an underused resource in terms of strategies for improving Antarctic climate projections for the 21st century and beyond. We identify priorities and suggest next steps to addressing this
Multiple deformation episodes at Myra Falls volcanic-hosted massive sulfide camp, central Vancouver Island, British Columbia, Canada
Musgos pleurocárpicos do Parque Estadual das Sete Passagens, Miguel Calmon, Bahia, Brasil
Sq and EEJ—A Review on the Daily Variation of the Geomagnetic Field Caused by Ionospheric Dynamo Currents
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Housing supply and brownfield regeneration in a post-Barker review world: A comparison of policy and practice in England and Scotland
The findings of the Barker review, which examined the reasons for the undersupply of UK housing, have important implications for the devolved constituents of the UK, including Scotland. This paper traces the emergence of the brownfield regeneration policy agenda across the UK and examines how the Barker review connects with this brownfield policy focus. The paper compares housing and brownfield policies and practices in England and Scotland, places them in an international context and elicits wider lessons for devolved governance in relation to housing policy, in terms of `centrist—local' tensions. Estimates based on published data suggest that Barker's emphasis on increased housing supply cannot easily be reconciled with the current emphasis on brownfield development and is likely to require a return to greenfield development in both countries
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