67 research outputs found
Is there an association between liver type fatty acid binding protein and severity of preeclampsia?
Objective The aim of this study was to estimate the level
of liver fatty acid binding protein (LFABP) in women with
preeclampsia.
Method A case–control study was conducted in 90
pregnant women who were divided into the following three
groups: normal pregnancy (n = 30), mild–moderate preeclampsia
(n = 30), and severe preeclampsia (n = 30).
Maternal blood samples were obtained during an antenatal
clinic visit in normal pregnant women, and at the time of
diagnosis in women with preeclampsia. Serum LFABP
levels were measured by the quantitative sandwich enzyme
immunoassay technique.
Results Serum LFABP level was significantly higher in
severe and mild–moderate preeclampsia groups than normal
pregnancy group (1,709.90 ± 94.82, 1,614.93 ±
118.22, and 1,532.36 ± 140.98 pg/ml, respectively;
p\0.001). In multivariate analysis, the severity of preeclampsia
was correlated with LFABP level [unadjusted
odds ratio (95 % confidence interval), 1.008 (1.003–1.012),
p\0.001 and LDH 1.063 (1.029–1.099), p\0.001].
Conclusion Maternal serum LFABP level appears to be
correlated with the severity of the preeclampsia and can be
used to confirm the diagnosis
Do follicular fluid advanced glycation end products levels affect the ovarian response in unexplained infertility?
Objective: To compare the advanced glycation end products (AGEs) levels in follicular fluid according to
the different ovarian responses of women who underwent controlled ovarian stimulation due to unexplained
infertility and to examine the relationship between these levels and pregnancy outcomes.
Methods: Sixty-three women who underwent fresh IVF/ICSI cycles with GNRH antagonist protocol were
divided into 3 groups according to the number of retrieved oocytes as suboptimal (4–9 oocytes), optimal
(10–15 oocytes) and high (>15 oocytes) responders. AGEs levels in follicular fluid were measured by
ELISA method.
Results: AGEs levels were 6.81 ± 2.20 mg/ml, 5.30 ± 2.01 and 6.44 ± 1.43 mg/ml in suboptimal, optimal and
high response group, respectively. AGEs level was significantly higher in suboptimal response group than
in optimal response group. The cutoff level of 6.19 mg/ml had a sensitivity of 59.3% and a specificity of
66.7% in distinguishing the suboptimal response group from the optimal response group. However, there
were no statistically significant difference between AGEs levels and clinical pregnancy and live birth rates.
Conclusion: Increased AGEs level in follicular fluid may be associated with decreased ovarian response
during controlled ovarian stimulation in unexplained infertility case, however, it does not provide information
about pregnancy outcomes
Biochemiczne markery pierwszego trymestru w ciąży bliźniaczej
Objective: Our aim was to investigate the first trimester serum markers and nuchal translucency (NT) measurements
in twin pregnancies in our population.
Materials and methods: We reviewed the results of all double tests that were performed in our hospital over
a three-year period. Out of them, we selected all twins and compared them with a group of three times as many
singleton controls. NT measurements and the first trimester serum markers from 49 twin pregnancies were compared
to those of 147 pregnant women with normal singleton pregnancy.
Results: There were no statistically significant differences in age, gestational age and maternal weight between
the two groups (p>0.05). We found similar NT measurements in the two groups. The median MoM of Pregnancy-
Associated Plasma Protein A (PAPP-A) and fβ-hCG levels in twins were statistically significantly higher than those in
singleton pregnancies. Twelve percent of the twins (12.2 %) were the result of assisted reproduction technologies.
IVF versus naturally conceived pregnancies showed similar MoM of PAPP-A (2.2 vs. 1.2, respectively) and fβ-hCG
(Mann-Whitney U; p = 0.195 and p = 0.958).
Conclusions: Our study revealed that median PAPP-A and fβ-hCG levels for twins were less than twice those of
singleton values.Cel pracy: Celem naszego badania było zbadanie surowiczych markerów pierwszego trymestru oraz przezierności
karkowej (NT) w ciążach bliźniaczych w naszej populacji.
Metoda: Przeanalizowano wyniki wszystkich testów podwójnych wykonanych w naszym szpitalu w ciągu trzech
lat. Wyodrębniono grupę ciąż bliźniaczych (n=49) i porównano ją z trzy razy większą grupą kontrolną prawidłowych
ciąż pojedynczych (n=147).
Wyniki: Nie znaleziono istotnych statystycznie różnic w wieku, wieku ciążowym i masie ciała ciężarnych pomiędzy
grupami (p>0,05). Stwierdzono podobne wyniki pomiaru NT w obu badanych grupach. Mediana MoM białka
PAPP-A i poziom fβ-hCGw ciążach bliźniaczych był istotnie wyższy niż w ciążach pojedynczych. Dwanaście procent
ciąż bliźniaczych było efektem technik wspomaganego rozrodu. Ciąże w wyniku IVF oraz ciąże spontaniczne
wykazywały się podobnych wynikiem MoM białka PAPP-A (2,2 vs. 1,2 odpowiednio) i fβ-hCG (Mann-Whitney U;
p=0,195 i p=0,958).
Wnioski: Średni poziom białka PAPP-A i fβ-hCG dla ciąż bliźniaczych był mniej niż dwa razy większy niż dla
pojedynczych ciąż
Iron Behaving Badly: Inappropriate Iron Chelation as a Major Contributor to the Aetiology of Vascular and Other Progressive Inflammatory and Degenerative Diseases
The production of peroxide and superoxide is an inevitable consequence of
aerobic metabolism, and while these particular "reactive oxygen species" (ROSs)
can exhibit a number of biological effects, they are not of themselves
excessively reactive and thus they are not especially damaging at physiological
concentrations. However, their reactions with poorly liganded iron species can
lead to the catalytic production of the very reactive and dangerous hydroxyl
radical, which is exceptionally damaging, and a major cause of chronic
inflammation. We review the considerable and wide-ranging evidence for the
involvement of this combination of (su)peroxide and poorly liganded iron in a
large number of physiological and indeed pathological processes and
inflammatory disorders, especially those involving the progressive degradation
of cellular and organismal performance. These diseases share a great many
similarities and thus might be considered to have a common cause (i.e.
iron-catalysed free radical and especially hydroxyl radical generation). The
studies reviewed include those focused on a series of cardiovascular, metabolic
and neurological diseases, where iron can be found at the sites of plaques and
lesions, as well as studies showing the significance of iron to aging and
longevity. The effective chelation of iron by natural or synthetic ligands is
thus of major physiological (and potentially therapeutic) importance. As
systems properties, we need to recognise that physiological observables have
multiple molecular causes, and studying them in isolation leads to inconsistent
patterns of apparent causality when it is the simultaneous combination of
multiple factors that is responsible. This explains, for instance, the
decidedly mixed effects of antioxidants that have been observed, etc...Comment: 159 pages, including 9 Figs and 2184 reference
Laparoscopic Removal of An Ectopic Intrauterine Device From The Anterior Abdominal Wall
The intrauterine devices (IUDs) have been used widely by women of childbearing years. In this report, we presented a case of a 25-year-old gravida 4, parity 3 woman with an abdominal wall penetration by an IUD. She had an IUD (TCu-380A) inserted immediately after dilatation & curettage. The IUD was removed laparoscopically
Recurrent Placental Abruption with Methylenetetrahydrofolate Reductase C667t Heterozygosity: A Case Report
Placental abruption although uncommon, can result in high rate of maternal and fetal morbidity and mortality. Several studies suggest abnormal placental vasculature, thrombosis and reduced placental perfusion in pathophysiology. Genetic variations may predispose to these problems.
Case: A thirty year old 28 weeks pregnant women underwent cesarean section with the diagnosis of placental abruption, intrauterine dead fetus and previous cesarean section in our clinic. It was learned that she had a cesarean section due to placental abruption 1 year ago. In the postoperative period trombophilia markers, methylenetetrahydrofolate reductase , Factor V leiden and Prothrombin gene polymorphism, homocystein, folate and vitamin B12 levels and genetic karyotyping were evaluated. The only pathology was the metylenetetrahydrofolate reductase gene heterozygosity for the C to T substitution at nucleotide 677.
Risk of recurrence is high in patients with a history of placental abruption. Antenatal care and delivery after fetal lung maturation is advised since the perinatal mortality is high with placental abruption
Evaluation of pain after uterine artery embolization
Objective: In this study our aim was to determine the severity of post procedure pain associated with uterine artery embolization (UAE). Study Design: Twenty-one women with symptomatic uterine fibroid were recruited for the study. The procedure was performed in the angiography unit under conscious sedation. All patients received prophylactic intravenous antibiotics and analgesic, ibuprofen 600 mg. At the completion of the procedure, all patients were given ibuprofen 600 mg orally every six hours. The patients were discharged with oral ibuprofen (600 mg 4 times daily). The main outcome measure was severity of pain. The instrument for evaluation of pain was visual analog scale. The measurements were taken at every hour. Results: Twenty-one procedures were performed. The mean age was 43.04±4.21 years (range 34-52) and median parity was 4 (0-6). The mean post procedure pain scores after 1, 2 and 3 hours were 3.33±2.00, 4.57±1.74, 4.95±1.71 respectively. After the completion of embolization, it was found that pain appeared to peak in the initial 3-4 post-embolization hours, reached a plateau and then declined by 9 hours. Conclusion: There is an increased need for post procedural pain control for UAE patients, especially in the first 6 hours after the procedure.Objective: In this study our aim was to determine the severity of post procedure pain associated with uterine artery embolization (UAE). Study Design: Twenty-one women with symptomatic uterine fibroid were recruited for the study. The procedure was performed in the angiography unit under conscious sedation. All patients received prophylactic intravenous antibiotics and analgesic, ibuprofen 600 mg. At the completion of the procedure, all patients were given ibuprofen 600 mg orally every six hours. The patients were discharged with oral ibuprofen (600 mg 4 times daily). The main outcome measure was severity of pain. The instrument for evaluation of pain was visual analog scale. The measurements were taken at every hour. Results: Twenty-one procedures were performed. The mean age was 43.04±4.21 years (range 34-52) and median parity was 4 (0-6). The mean post procedure pain scores after 1, 2 and 3 hours were 3.33±2.00, 4.57±1.74, 4.95±1.71 respectively. After the completion of embolization, it was found that pain appeared to peak in the initial 3-4 post-embolization hours, reached a plateau and then declined by 9 hours. Conclusion: There is an increased need for post procedural pain control for UAE patients, especially in the first 6 hours after the procedure
Retrospective Analysis of Culture Results of Cases with Acute Vulvovaginitis: University Experience
OBJECTIVE: To analyse the results of the vaginal cultures and find out the prevalence of pathogens in patients with acute vulvovaginitis, retrospectively.
STUDY DESIGN: Vaginal cultures results of patients with the diagnosis of acute vulvovaginitis were analyzed retrospectively between June 2005 and January 2006.
RESULTS: Totally 241 patients were included in the study within 6 months time period. Mean age of patients was 30,63±6,87 changing between 19 and 57 years. While there was no pathogen detected in 18,3% (44/241) of vaginal cultures, various pathogens growed in 81,7% (197/241) of cultures. Normal vaginal flora was detected in 70,6% (139/197) of cultures with growth. The second most common
pathogen was Candida subspecies with a rate of 14,2% (28/197). Other pathogens were Candida albicans, E.coli, Gardnerella vajinalis, Klebsiella pneumonia, Candida subspecies and Klebsiella, Candida albicans and Klebsiella, Candida albicans and Gardnerella vajinalis with a rate of %7,1 (14/197), %4,1 (8/197), %2 (4/197), %0,5 (1/197), %0,5 (1/197), %0,5 (1/197) and %0,5 (1/197) respectively.
CONCLUSION: The most frequent pathogen detected in culture of patients with acute vulvovaginitis was candida subspecies in our clinic
Subarachnoid Hemorrhage of Unknown Origin During Pregnancy: Case Report
Subarachnoid hemorrhage (SAH) is a stroke subtype resulting from leakage of blood. The incidence of SAH during pregnancy varies from 1 to 2 per 10000 pregnancies. The most frequent (%85) cause of SAH is a ruptured cerebral aneurysm.
A 39-year-old woman at 33 weeks’ gestation experienced abrupt onset of severe headache, neck stiffness, photophobia, and vomiting and was admitted to the hospital and diagnosed as SAH. On neurological examination, no deficits were apparent. A magnetic resonance imaging showed a subarachnoid hemorrhage. Lumbar puncture was performed and SAH was confirmed. It was decided to proceed with a caesarean section. After cesarean delivery of a healthy infant, the patient immediately underwent cerebral angiography, which was normal. Eight days after the initial cerebral angiography, a second angiography demonstrated a suspicious aneurysm and vasospasm; therefore a third angiography was performed and was found normal. At discharge and at clinical follow-up, our patient was asymptomatic.
Patients with significant SAH and negative cerebral angiography findings should be considered for further diagnostic testing including repeat cerebral angiography
ABO blood group and risk of pancreatic cancer in a Turkish population in Western Blacksea region
Background: We aimed to investigate the relationship between blood groups and pancreatic cancer in a Turkish population in Western Blacksea region. Methods: This is a retrospective study. Zonguldak Karaelmas University outpatient oncology clinic records were screened for the period between 2004 and 2011. Results: The median age of patients were 56 (±16) and 132 of 633 study population had pancreatic cancer. Pancreatic cancer patients had significantly higher rates of blood group A compared to controls (OR 1.8, 95%CI, p 0.005). Rates of blood group AB was significantly lower than the control group (OR 0.37, 95% CI, p 0.04). The median survival (IR) time in subjects having the blood groups A, B, AB and O were 7.0 (1-28), 7.0 (2-38), 10 (2-36) and 9.0 (2-48) months respectively; the blood group 0 had significantly higher overall survival (OS) compared to the non-0 groups (p 0.04). Conclusions: Pancreatic cancer patients had more common blood group A in our population. Moreover, blood group AB appeared to be a protective factor against pancreatic cancer in our population. Blood group 0 had a significantly longer survival compared to non-0, regardless of prognostic factors
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