Comparison of Requirements for Composite Structures for Aircraft and Space Applications

In this report, the aircraft and space vehicle requirements for composite structures are compared. It is a valuable exercise to study composite structural design approaches used in the airframe industry and to adopt methodology that is applicable for space vehicles. The missions, environments, analysis methods, analysis validation approaches, testing programs, build quantities, inspection, and maintenance procedures used by the airframe industry, in general, are not transferable to spaceflight hardware. Therefore, while the application of composite design approaches from aircraft and other industries is appealing, many aspects cannot be directly utilized. Nevertheless, experiences and research for composite aircraft structures may be of use in unexpected arenas as space exploration technology develops, and so continued technology exchanges are encouraged

Multiple Phosphatidylinositol 3-Kinases Regulate Vaccinia Virus Morphogenesis

Poxvirus morphogenesis is a complex process that involves the successive wrapping of the virus in host cell membranes. We screened by plaque assay a focused library of kinase inhibitors for those that caused a reduction in viral growth and identified several compounds that selectively inhibit phosphatidylinositol 3-kinase (PI3K). Previous studies demonstrated that PI3Ks mediate poxviral entry. Using growth curves and electron microscopy in conjunction with inhibitors, we show that that PI3Ks additionally regulate morphogenesis at two distinct steps: immature to mature virion (IMV) transition, and IMV envelopment to form intracellular enveloped virions (IEV). Cells derived from animals lacking the p85 regulatory subunit of Type I PI3Ks (p85α−/−β−/−) presented phenotypes similar to those observed with PI3K inhibitors. In addition, VV appear to redundantly use PI3Ks, as PI3K inhibitors further reduce plaque size and number in p85α−/−β−/− cells. Together, these data provide evidence for a novel regulatory mechanism for virion morphogenesis involving phosphatidylinositol dynamics and may represent a new therapeutic target to contain poxviruses

Control of urea hydrolysis and nitrification in soil by chemicals - Prospects and problems

A review is made of the recent work to assess the prospects of regulating urea hydrolysis and nitrification processes in soils by employing chemicals that can retard urea hydrolysis and nitrification. The possible benefits from control of nitrogen transformations in terms of conserving and enhancing fertilizer nitrogen efficiency for crop production and the problems associated with their use with regard to N metabolism of plants have also been discussed with examples. Prospects of using cheap and effective indigenous materials and chemicals for control of urea hydrolysis and nitrification under specific soil situations appear eminent in improving the fertilizer nitrogen efficiency. Urease inhibitors may be helpful in reducing problems associated with ammonia volatilization if this is not offset by leaching of urea. On the other hand retardation of nitrification appears useful in reducing losses that accompany nitrification due to leaching and denitrification, and with the plants that metabolize equally well with relatively higher amounts of NH4–N may be more effective in improving the utilization of fertilizer N under these situation

Observations of waves and currents during barrier island inundation

Overwash and inundation on barrier islands can transport sediment onshore, leading to vertical accretion. These processes could ensure barrier island growth in times of sea-level rise, but wave and current fields during overwash and inundation are not well understood. Field data of water levels, waves, and currents were collected on a barrier island in the Netherlands to investigate the hydrodynamics during island inundation. Observations show that even in shallow water depths (<0.5 m) wave energy was not completely dissipated as waves propagated from the North Sea onshore. Additionally, locally generated wind waves entered the field area from the Wadden Sea and propagated offshore. Infragravity waves were an important part of the wave field, particularly onshore of the beach crest. They were observed to be onshore progressive and displayed a bore-like shape when water depths were shallow. Wave breaking was the dominant dissipation mechanism for high-frequency waves as well as for infragravity waves, which is in agreement with prior research on infragravity wave energy dissipation on mild sloping (closed-boundary) beaches. A large-scale offshore directed water-level gradient between the Wadden Sea and the North Sea side, caused by elevated water levels in the Wadden Sea during the storms, frequently drove an offshore flow if it was large enough to exceed the cross-shore gradient due to wave setup. In addition, elevated water levels in the Wadden Sea decreased current velocities due to a decrease in water-level gradients. This study highlights the influence of back-barrier processes on the hydrodynamics during inundation