15,484 research outputs found
Ab Initio Treatment of Collective Correlations and the Neutrinoless Double Beta Decay of Ca
Working with Hamiltonians from chiral effective field theory, we develop a
novel framework for describing arbitrary deformed medium-mass nuclei by
combining the in-medium similarity renormalization group with the generator
coordinate method. The approach leverages the ability of the first method to
capture dynamic correlations and the second to include collective correlations
without violating symmetries. We use our scheme to compute the matrix element
that governs the neutrinoless double beta decay of Ca to Ti, and
find it to have the value , near or below the predictions of most
phenomenological methods. The result opens the door to ab initio calculations
of the matrix elements for the decay of heavier nuclei such as Ge,
Te, and Xe.Comment: 6 pages, 4 figures and 1 table. supplementary material included.
version to be publishe
Microprobe Analysis of Element Distribution in Bovine Extracellular Matrices and Muscle
The concentrations of some essential elements, Na, K, P, S and Cl were determined by microprobe analysis in bovine extracellular matrices of cartilage, tendon and elastic tissue (ligamentum nuchae) and in muscle cells. The values for the different tissues were compared and related to the blood electrolyte concentrations. Among the connective tissues the highest Na and lowest Cl values were found for cartilage which bears a high negative charge. The lowest concentrations of these elements occurred in elastic tissue which is relatively non-polar. In the three extracellular matrices sodium levels exceeded potassium. In myofibers potassium was the major cation at 30 times the blood value and about 3 times the concentration of sodium. Chlorine values were around 0.4 that of blood. Sulfur and phosphorus are components of the tissue macromolecules. The negative charge on the extracellular matrices is a function of carboxyl and sulfate radicals. In the myofiber this property is largely attributable to carboxyl and phosphate groups. Differences in potassium-sodium distribution in cells and extracellular matrices are attributed partly to the microtrabecular lattice and to the ordered state of cell water. In general the element concentrations and selective distribution can be related to the chemical composition and organization of the tissue, the net immobile charge, the nature of the dispersion medium (water) and changes in its dielectric constant, and to the physico-chemical properties of the individual ions
Microprobe Analysis of Element Distribution in Rabbit and Dog Erythrocytes as Examples of High and Low Potassium Cells
The concentrations of Na, Mg, P, S, Cl, K and Fe were determined by microprobe in near 100% hematocrit suspensions of rabbit and dog erythrocytes prepared by freezing and drying. These cells are representative, respectively, of high potassium, low sodium, and high sodium, low potassium cells. Water contents of the cells were the same, as were, approximately, the levels of Cl, S and Fe. Rabbit P was nearly double that of the dog. For the rabbit, the cell Na/K ratio was 0.21 and for the dog 15.4, illustrating the major diffusible electrolyte difference between these two types of cell. The rabbit erythrocytes showed an apparent negative immobile charge density of 95 meq/kg of cell water and the dog 56 meq/kg cell water, a distinct difference. Serum electrolytes in the two species are exactly comparable (Standard Tables). Ionic distribution in these cell types was treated by the Gibbs-Duhem equation representing two heterogeneous systems in thermodynamic equilibrium with the blood serum. Factors to be considered are: (1) the composition of the erythrocyte and its net immobile charge; (2) the physicochemical properties of the individual ions (charge, ionic radius, hydration energy, standard chemical potential); (3) the dielectric constant of the dispersion medium (in this case, water); and (4) the binding constants of the ions. The hypothesis of active transport (the sodium-potassium pump) is specifically rejected as an explanation of ionic differences
Letter to the Editor by M.B. Engel and H.R. Catchpole Relating to: Can We See Living Structures in the Cell [by G.N. Ling, Scanning Microscopy Vol. 6, p. 405-450 (1992)] and Reply by G.N. Ling
Dear Editor,
As workers in the field of ionic equilibrium in extracellular matrices and cells, and as contributors to this Journal of papers supporting an alternative explanation to that represented by the dominant schools of active transport (ionic pumps), we are surprised by the statement of Ling (1992, p. 449) which appears to limit published criticism of those schools to himself and A.S. Troshin. By an odd coincidence, our abstract (Catchpole et al., 1951) on the distribution of potassium and sodium through selective action of the cations with ground substance and water appeared simultaneously with that of Ling (1951): Tentative hypothesis for selective ionic accumulation in muscle cells . We have also published papers and monographs since that distant time. So much, at least, for longevity
Changes in r-process abundances at late times
We explore changes in abundance patterns that occur late in the r process. As
the neutrons available for capture begin to disappear, a quasiequilibrium
funnel shifts material into the large peaks at A=130 and A=195, and into the
rare-earth "bump" at A=160. A bit later, after the free-neutron abundance has
dropped and beta-decay has begun to compete seriously with neutron capture, the
peaks can widen. The degree of widening depends largely on neutron-capture
rates near closed neutron shells and relatively close to stability. We identify
particular nuclei the capture rates of which should be examined experimentally,
perhaps at a radioactive beam facility.Comment: 8 pages, 14 figures included in tex
Spin Hall Drag
We predict a new effect in electronic bilayers: the {\it Spin Hall Drag}. The
effect consists in the generation of spin accumulation across one layer by an
electric current along the other layer. It arises from the combined action of
spin-orbit and Coulomb interactions. Our theoretical analysis, based on the
Boltzmann equation formalism, identifies two main contributions to the spin
Hall drag resistivity: the side-jump contribution, which dominates at low
temperature, going as , and the skew-scattering contribution, which is
proportional to . The induced spin accumulation is large enough to be
detected in optical rotation experiments.Comment: 5 pages, 2 figure
Remnant Break-up and Muon Production in Cosmic Ray Air Showers
We discuss the relation between remnant fragmentation in inelastic
high-energy hadronic interactions and muon production in extensive cosmic ray
air showers. Using a newly developed tool, a simple and flexible hadronic event
generator, we analyze the forward region of hadronic interactions. We show that
measurements of the Feynman-x distribution in the beam fragmentation region at
LHCf will be key to understanding muon production in air showers
quantitatively.Comment: 6 pages, 6 figure
The multiple signaling modalities of adhesion G protein-coupled receptor GPR126 in development
The G protein-coupled receptor (GPCR) superfamily is the largest known receptor family in the human genome. Although the family of adhesion GPCRs comprises the second largest sub-family, their function is poorly understood. Here, we review the current knowledge about the adhesion GPCR family member GPR126. GPR126 possesses a signal peptide, a 7TM domain homologous to secretin-like GPCRs, a GPS motif and an extended N-terminus containing a CUB (Complement, Uegf, Bmp1) domain, a PTX (Pentraxin) domain, a hormone binding domain and 27 putative N-glycosylation sites. Knockdown and knockout experiments in zebrafish and mice have demonstrated that Gpr126 plays an essential role in neural, cardiac and ear development. In addition, genome-wide association studies have implicated variations at the GPR126 locus in obstructive pulmonary dysfunction, in scoliosis and as a determinant of trunk length and body height. Gpr126 appears to exert its function depending on the organ system via G protein- and/or N-terminus-dependent signaling. Here, we review the current knowledge about Gpr126, which, due to the variety of its functions and its multiple signaling modalities, provides a model adhesion GPCR to understand general functional concepts utilized by adhesion GPCRs
The multiple signaling modalities of adhesion G protein-coupled receptor GPR126 in development
The G protein-coupled receptor (GPCR) superfamily is the largest known receptor family in the human genome. Although the family of adhesion GPCRs comprises the second largest sub-family, their function is poorly understood. Here, we review the current knowledge about the adhesion GPCR family member GPR126. GPR126 possesses a signal peptide, a 7TM domain homologous to secretin-like GPCRs, a GPS motif and an extended N-terminus containing a CUB (Complement, Uegf, Bmp1) domain, a PTX (Pentraxin) domain, a hormone binding domain and 27 putative N-glycosylation sites. Knockdown and knockout experiments in zebrafish and mice have demonstrated that Gpr126 plays an essential role in neural, cardiac and ear development. In addition, genome-wide association studies have implicated variations at the GPR126 locus in obstructive pulmonary dysfunction, in scoliosis and as a determinant of trunk length and body height. Gpr126 appears to exert its function depending on the organ system via G-protein- and/or N-terminus-dependent signaling. Here, we review the current knowledge about Gpr126, which, due to the variety of its functions and its multiple signaling modalities, provides a model adhesion GPCR to understand general functional concepts utilized by adhesion GPCRs
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