Vascular neurocognitive disorders and the vascular risk factors

Dementias are clinical neurodegenerative diseases characterized by permanent and progressive transformation of cognitive functions such as memory, learning capacity, attention, thinking, language, passing judgments, calculation or orientation. Dementias represent a relatively frequent pathology, encountered at about 10% of the population of 65-year olds and 20% of the population of 80-year olds. This review presents the main etiological forms of dementia, which include Alzheimer form of dementia, vascular dementia, dementia associated with alpha-synucleionopathies, and mixed forms. Regarding vascular dementia, the risk factors are similar to those for an ischemic or hemorrhagic cerebrovascular accident: arterial hypertension, diabetes mellitus, dyslipidemia, smoking, obesity, age, alcohol consumption, cerebral atherosclerosis/ arteriosclerosis. Several studies show that efficient management of the vascular risk factors can prevent the expression and/ or progression of dementia. Thus, lifestyle changes such as stress reduction, regular physical exercise, decreasing dietary fat, multivitamin supplementation, adequate control of blood pressure and serum cholesterol, and social integration and mental stimulation in the elderly population are important factors in preventing or limiting the symptoms of dementia, a disease with significant individual, social, and economic implications

Bridging the Flexibility Concepts in the Buildings and Multi-energy Domains

paper aims to stimulate a discussion on how to create a bridge between the concept of flexibility used in power and energy systems and the flexibility that buildings can offer for providing services to the electrical system. The paper recalls the main concepts and approaches considered in the power systems and multi-energy systems, and summarises some aspects of flexibility in buildings. The overview shows that there is room to strengthen the contacts among the scientists operating in these fields. The common aim is to identify the complementary aspects and provide inputs to enhance the methodologies and models to enable and support an effective energy and ecologic transition

Interaction with Nearly Environment and Old Structure for a Deep Excavation. Case History in Bucharest

The paper presents the influence of a deep excavation performed in Bucharest on the adjacent ground and on some old buildings around it; the damages and effects appeared during the excavation and the remedial measures are presented in detail, too. The excavation was designed to be 16.15 meters deep, sustained by a slurry wall enclosure of 60 cm thickness and pre-stressed anchors, and steel struts. Due to an accident that occured to the trench walls, a thorough monitoring by instrumentation started. The results of this monitoring are shown

Vascular neurocognitive disorders and the vascular risk factors

Dementias are clinical neurodegenerative diseases characterized by permanent and progressive transformation of cognitive functions such as memory, learning capacity, attention, thinking, language, passing judgments, calculation or orientation. Dementias represent a relatively frequent pathology, encountered at about 10% of the population of 65-year olds and 20% of the population of 80-year olds. This review presents the main etiological forms of dementia, which include Alzheimer form of dementia, vascular dementia, dementia associated with alpha-synucleionopathies, and mixed forms. Regarding vascular dementia, the risk factors are similar to those for an ischemic or hemorrhagic cerebrovascular accident: arterial hypertension, diabetes mellitus, dyslipidemia, smoking, obesity, age, alcohol consumption, cerebral atherosclerosis/ arteriosclerosis. Several studies show that efficient management of the vascular risk factors can prevent the expression and/ or progression of dementia. Thus, lifestyle changes such as stress reduction, regular physical exercise, decreasing dietary fat, multivitamin supplementation, adequate control of blood pressure and serum cholesterol, and social integration and mental stimulation in the elderly population are important factors in preventing or limiting the symptoms of dementia, a disease with significant individual, social, and economic implications

Complex reconstruction after extreme Fournier’s gangrene; a case report

In this article we present a severe case of Fournier\u27s gangrene (FG) that affected a 64-year-old male patient, with no other known comorbidities. FG is a type of necrotizing fasciitis of the perineal and genital regions, that affects mostly males in the 5th-7th decades, with mortality rates that reach 70%. The infection usually advances through the superficial fascial layers of the perineum and abdomen and affects the skin. In our case the infection also affected the spermatic fasciae and advanced in the abdominal and pelvic cavities, abdominal muscles, and surrounding soft tissues. Subsequent debridement left the patient with large soft tissue and muscle defects and an open abdominal cavity that needed reconstruction. We designed two pedicled tensor fascia lata flaps with extra fascia for abdominal support. Healing was marked by a pseudomonas aeruginosa infection that led to skin graft sloughing and marginal wound breakdown, which was treated with antibiotics and local wound care. Eventually the wounds healed, and the patient left the hospital 11 weeks after admittance. The outcome of the case was good considering the initial extent of the infection. The cosmetic shortcomings were not shared by the patient and future scar corrections are planned

Sensitivity study of forecasted aftershock seismicity based on Coulomb stress calculation and rate- and state-dependent frictional response

We use the Dieterich (1994) physics-based approach to simulate the spatio- temporal evolution of seismicity caused by stress changes applied to an infinite population of nucleating patches modeled through a rate- and state- dependent friction law. According to this model, seismicity rate changes depend on the amplitude of stress perturbation, the physical constitutive properties of faults (represented by the parameter Aσ), the stressing rate and the background seismicity rate of the study area. In order to apply this model in a predictive manner, we need to understand the impact of physical model parameters and the correlations between them. Firstly we discuss different definitions of the reference seismicity rate and show their impact on the computed rate of earthquake production for the 1992 Landers earthquake sequence as a case study. Furthermore, we demonstrate that all model parameters are strongly correlated for physical and statistical reasons. We discuss this correlation emphasizing that the estimations of the background seismicity rate, stressing rate and Aσ are strongly correlated to reproduce the observed aftershock productivity. Our analytically derived relation demonstrates the impact of these model parameters on the Omori-like aftershock decay: the c- value and the productivity of the Omori law, implying a p-value smaller or equal to 1. Finally, we discuss an optimal strategy to constrain model parameters for near-real time forecasts

Sudden drop of fractal dimension of electromagnetic emissions recorded prior to significant earthquake

The variation of fractal dimension and entropy during a damage evolution process, especially approaching critical failure, has been recently investigated. A sudden drop of fractal dimension has been proposed as a quantitative indicator of damage localization or a likely precursor of an impending catastrophic failure. In this contribution, electromagnetic emissions recorded prior to significant earthquake are analysed to investigate whether they also present such sudden fractal dimension and entropy drops as the main catastrophic event is approaching. The pre-earthquake electromagnetic time series analysis results reveal a good agreement to the theoretically expected ones indicating that the critical fracture is approaching