Finite Density QCD in the Chiral Limit

We present the first results of an exact simulation of full QCD at finite density in the chiral limit. We have used a MFA (Microcanonical Fermionic Average) inspired approach for the reconstruction of the Grand Canonical Partition Function of the theory; using the fugacity expansion of the fermionic determinant we are able to move continuously in the ($\beta -\mu$) plane with $m=0$.Comment: 3 pages, LaTeX, 3 figures, uses espcrc2.sty, psfig. Talk presented by A. Galante at Lattice 97. Correction of some reference

Modelling Enzymatic Reduction of 2-keto-D-glucose by Suspended Aldose Reductase

Batch experiments have been systematically carried out at 25 °C, pH = 7, over 24- 76 h reaction time in order to evaluate the activity of a commercial (recombinant human) aldose reductase (ALR) used to catalyze the reduction of 2-keto-D-glucose (kDG) to fructose using NADPH as cofactor, by employing various enzyme/reactants initial ratios. A kinetic model was proposed by extending the ‘core’ reaction mechanism proposed in literature for the reduction of several saccharides and keto-derivates (glucose, galactose, xylose, glyceraldehydes) by the human or animal ALR (wild or modified), or by similar aldo-keto reductases (e.g. sorbitol dehydrogenase, xylose reductase) in the presence of NAD(P)H. The reaction pathway assumes a very quick reversible formation of a stable ALR•NADPH complex, from which a small fraction is binding the substrate thus determining a succession of Bi-Bi reversible reactions leading to the final product (fructose). Model parameters have been estimated based on the recorded data sets of four observable key-species, being in concordance with the reported values in literature for similar processes. The results confirm the conformational change of E•NADP+ complex allowing the release of NADP+ as being the rate-limiting step of the overall process. The results also underline the necessity to stabilize the fast deactivating enzyme by immobilization, as well as the requirement of a continuous in-situ regeneration of the cofactor

Tectonic and stratigraphic evolution based on seismic sequence stratigraphy: Central rift section of the campos basin, offshore brazil

The rift section of the Brazilian basins represent the sedimentary record associated with the first stages of Gondwana break‐up in the Early Cretaceous phase (Berriasian to Aptian). The rift succession of the Campos Basin constitutes one of the main petroleum systems of Brazil’s marginal basins. This interval contains the main source rock and important reservoirs in the Lagoa Feia Group deposits. The Lagoa Feia Group is characterized by siliciclastic, carbonate and evaporite sediments deposited during the rift and post‐rift phases. Despite the economic relevance, little is known in stratigraphic terms regarding this rift interval. To date, most studies of the Lagoa Feia Group have adopted a lithostratigraphic approach, while this study proposes a tectonostrati-graphic framework for the deep‐rift succession of the Campos Basin (Lagoa Feia Group), using the fundamentals of seismic sequence stratigraphy. This work also aims to establish a methodological and practical procedure for the stratigraphic analysis of rift basins, using seismic data and seismofacies, and focusing on tectonicstratigraphic analysis. The dataset comprised 2D seismic lines, core and lithological logs from exploration wells. Three seismic facies were identified based on reflector patterns and lithologic data from well cores, providing an improved subdivision of the pre‐, syn‐ and post‐rift stages. The syn‐rift stage was further subdivided based on the geometric patterns of the reflectors. Tectonics was the main controlling factor in the sedimentary succession, and the pattern and geometry of the seismic reflectors of the syn‐rift interval in the Campos Basin allowed the identification of three tectonic systems tracts: (i) a Rift Initiation Systems Tract; (ii) a High Tectonic Activity Systems Tract and (iii) a Low Tectonic Activity Systems Tract

On the symbolic powers of binomial edge ideals

We show that under some conditions, if the initial ideal in$_<(I)$ of an ideal $I$ in a polynomial ring has the property that its symbolic and ordinary powers coincide, then the ideal $I$ shares the same property. We apply this result to prove the equality between symbolic and ordinary powers for binomial edge ideals with quadratic Gr\"obner basis

A criterion for separating process calculi

We introduce a new criterion, replacement freeness, to discern the relative expressiveness of process calculi. Intuitively, a calculus is strongly replacement free if replacing, within an enclosing context, a process that cannot perform any visible action by an arbitrary process never inhibits the capability of the resulting process to perform a visible action. We prove that there exists no compositional and interaction sensitive encoding of a not strongly replacement free calculus into any strongly replacement free one. We then define a weaker version of replacement freeness, by only considering replacement of closed processes, and prove that, if we additionally require the encoding to preserve name independence, it is not even possible to encode a non replacement free calculus into a weakly replacement free one. As a consequence of our encodability results, we get that many calculi equipped with priority are not replacement free and hence are not encodable into mainstream calculi like CCS and pi-calculus, that instead are strongly replacement free. We also prove that variants of pi-calculus with match among names, pattern matching or polyadic synchronization are only weakly replacement free, hence they are separated both from process calculi with priority and from mainstream calculi.Comment: In Proceedings EXPRESS'10, arXiv:1011.601

Assessment of the total precipitable water from a sun photometer, microwave radiometer and radiosondes at a continental site in southeastern Europe

In this study, we discuss the differences in the total precipitable water (TPW), retrieved from a Cimel sun photometer operating at a continental site in southeast Europe, between version 3 (V3) and version 2 (V2) of the AErosol RObotic NETwork (AERONET) algorithms. In addition, we evaluate the performance of the two algorithms comparing their product with the TPW obtained from a collocated microwave radiometer and nearby radiosondes during the period 2007–2017. The TPW from all three instruments was highly correlated, showing the same annual cycle, with lower values during winter and higher values during summer. The sun photometer and the microwave radiometer depict the same daily cycle, with some discrepancies during early morning and late afternoon due to the effect of solar zenith angle on the measurements of the photometer. The TPW from V3 of the AERONET algorithm has small differences compared with V2, mostly related to the use of the new laboratory-based temperature coefficients used in V3. The microwave radiometer measurements are in good agreement with those obtained by the radiosonde, especially during night-time when the differences between the two instruments are almost negligible. The comparison of the sun photometer data with high-quality independent measurements from radiosondes and the radiometer shows that the absolute differences between V3 and the other two datasets are slightly higher compared with V2. However, V3 has a lower dependence from the TPW and the internal sensor temperature, indicating a better performance of the retrieving algorithm. The calculated one-sigma uncertainty for V3 as estimated, from the comparison with the radiosondes, is about 10&thinsp;%, which is in accordance with previous studies for the estimation of uncertainty for V2. This uncertainty is further reduced to about 6&thinsp;% when AERONET V3 is compared with the collocated microwave radiometer. To our knowledge, this is the first in-depth analysis of the V3 TPW, and although the findings presented here are for a specific site, we believe that they are representative of other mid-latitude continental stations.</p

The Rewiring of Ubiquitination Targets in a Pathogenic Yeast Promotes Metabolic Flexibility, Host Colonization and Virulence

Funding: This work was funded by the European Research Council [http://erc.europa.eu/], AJPB (STRIFE Advanced Grant; C-2009-AdG-249793). The work was also supported by: the Wellcome Trust [www.wellcome.ac.uk], AJPB (080088, 097377); the UK Biotechnology and Biological Research Council [www.bbsrc.ac.uk], AJPB (BB/F00513X/1, BB/K017365/1); the CNPq-Brazil [http://cnpq.br], GMA (Science without Borders fellowship 202976/2014-9); and the National Centre for the Replacement, Refinement and Reduction of Animals in Research [www.nc3rs.org.uk], DMM (NC/K000306/1). The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. Acknowledgments We thank Dr. Elizabeth Johnson (Mycology Reference Laboratory, Bristol) for providing strains, and the Aberdeen Proteomics facility for the biotyping of S. cerevisiae clinical isolates, and to Euroscarf for providing S. cerevisiae strains and plasmids. We are grateful to our Microscopy Facility in the Institute of Medical Sciences for their expert help with the electron microscopy, and to our friends in the Aberdeen Fungal Group for insightful discussions.Peer reviewedPublisher PD