Silver nanoparticles – Expired medicinal drugs waste accumulated at hail city for the local manufacturing of green corrosion inhibitor system for steel in acidic environment

The aim of the present study is to avoid the accumulation of expired drugs and chemicals in Hail City Saudi Arabia by using it for the manufacturing of eco-friendly corrosion inhibitors as a local product for the Hail area. The current study looks at Ag nanoparticles' green synthesis, characterization, and inhibitory properties. Silver nitrate (AgNO3) was used as a precursor, sodium citrate as a reducing agent, and polyvinyl alcohol (PVA) as a stabilizer in the chemical reduction procedure. The effect of adding expired Baclofen drug (EMBD) collected from the Hail area to the nanoparticles was investigated. The addition of PVA and expired pharmaceuticals to the nanoparticles increased the corrosion inhibition of steel. The researchers looked at the effects of nanoparticle concentrations, reaction temperature, and mixing nanomaterials with medications. With rising nanoparticle concentrations, expired drug concentrations, and reaction temperature, corrosion inhibition was observed to rise. The inhibition is caused by nanoparticle adsorption on steel surfaces that follow the Langmuir Isotherm. The addition of EMBD to nanomaterials improved their inhibitory performance, which was found to be (Nano2- EMBD) > (Nano1- EMBD) > (Nano2) > (Nano1) > (EMBD), in that order. Nanomaterials are promoted by the expiring medication meaning that, the synergistic effect happens between nanomaterials and drug systems. The results of potentiodynamic polarization as electrochemical measurements show that the inhibitor system (Nano2- EMBD) acts as a mixed-type. Electrochemical impedance spectroscopy (EIS) data show that the inhibitor system improves polarization resistance and inhibition performance by adhering to the metal/electrolyte interface

The effective adsorption of arsenic from polluted water using modified Halloysite nanoclay

The presented research applied the modified Halloysite nanoclay to boost the adsorption efficacy of heavy metals from the water. To improve As (III) adsorption effectiveness from water, the study assessed the characteristics of the prepared materials and improved the experimental conditions. The study was optimized the experimental condition with a dosage of 1 g/L, contact time of 90 min, the solution pH of 8, and the initial concentration of 5 ppm of As (III). The optimization was performed in distilled water and later the experiments were conducted in the real polluted water. The modified Halloysite nanoclay’s physical characteristics were investigated using techniques like X-ray diffraction, scanning and transmission electron microscopy, Fourier transform infrared spectroscopy, and surface area analysis. The experimental result shows the adsorption efficiency of 82.4 % of As (III) at the optimized condition during the usage of modified Halloysite nanoclay. To create a suitable mathematical model for a better description of the interactions between pollutants and solid adsorbents, it is helpful to analyze the process kinetically. The removal process of As (III) was studied kinetically and the observation shows the pseudo-second order kinetics

Study of reactivity of cyanoacetohydrazonoethyl-<i>N</i>-ethyl-<i>N</i>-methyl benzenesulfonamide: preparation of novel anticancer and antimicrobial active heterocyclic benzenesulfonamide derivatives and their molecular docking against dihydrofolate reductase

<p>This article describes the synthesis of some novel heterocyclic sulfonamides having biologically active thiophene <b>3</b>, <b>4</b>, <b>5</b>, <b>6</b>, coumarin <b>8</b>, benzocoumarin <b>9</b>, thiazole <b>7</b>, piperidine <b>10</b>, pyrrolidine <b>11</b>, pyrazole <b>14</b> and pyridine <b>12</b>, <b>13</b>. Starting with 4-(1-(2-(2-cyanoacetyl)hydrazono)ethyl)-N-ethyl-N-methylbenzenesulfonamide <b>(2)</b>, which was prepared from condensation of acetophenone derivative <b>1</b> with 2-cyanoacetohydrazide. The structures of the newly synthesized compounds were confirmed by elemental analysis, IR, ¹H NMR, ¹³C NMR, ¹⁹F NMR and MS spectral data. All the newly synthesized heterocyclic sulfonamides were evaluated as <i>in-vitro</i> anti-breast cancer cell line (MCF7) and as <i>in-vitro</i> antimicrobial agents. Compounds <b>8</b>, <b>5</b> and <b>11</b> were more active than MTX reference drug and compounds <b>12</b>, <b>7</b>, <b>4</b>, <b>14</b>, <b>5</b> and <b>8</b> were highly potent against <i>Klebsiella pneumonia</i>. Molecular operating environment performed virtual screening using molecular docking studies of the synthesized compounds. The results indicated that some prepared compounds are suitable inhibitor against dihydrofolate reductase (DHFR) enzyme (PDBSD:4DFR) with further modification.</p