Measurement of the trailing edge of cosmic-ray track signals from a round-tube drift chamber

The trailing edge of tube drift-chamber signals for charged particles is expected to provide information concerning the particle passage time. This information may be useful for separating meaningful signals from overlapping garbage at high-rate experiments, such as the future LHC experiments. We carried out a cosmic-ray test using a small tube chamber in order to investigate the feasibility of this idea. We achieved a trailing-edge time resolution of 12 ns in rms by applying simple pulse shaping to eliminate a signal tail. A comparison with a Monte Carlo simulation indicates the importance of well-optimized signal shaping to achieve good resolution. The resolution may be further improved with better shaping.Comment: 13 pages including 9 figure

Development and a SEU Test of a TDC LSI for the ATLAS Muon Detector

A new TDC LSI (AMT-2) for the ATLAS Muon detector has been developed. The AMT-2 chip is a successor of the previous prototype chip (AMT-1). The design of the chip was polished up for aiming mass production of 20,000 chips in year 2002. Especially, power consumption of the chip was reduced to less than half of the previous chip by introducing newly developed LVDS receivers. The AMT-2 was processed in a 0.3 mu m CMOS Gate-Array technology. It achieved 300 ps timing resolution and includes several data buffers, trigger matching circuit, JTAG interface and so on. First SEU test by using a proton beam was recently performed. Although the test results are very preliminary at present stage, we get very low SEU rate safely used in ATLAS environment. (7 refs)

Mechanism of magnetostructural transformation in multifunctional Mn3_3GaC

Mn$_3$GaC undergoes a ferromagnetic to antiferromagnetic, volume discontinuous cubic-cubic phase transition as a function of temperature, pressure and magnetic field. Through a series of temperature dependent x-ray absorption fine structure spectroscopy experiments at the Mn K and Ga K edge, it is shown that the first order magnetic transformation in Mn$_3$GaC is entirely due to distortions in Mn sub-lattice and with a very little role for Mn-C interactions. The distortion in Mn sub-lattice results in long and short Mn-Mn bonds with the longer Mn-Mn bonds favoring ferromagnetic interactions and the shorter Mn-Mn bonds favoring antiferromagnetic interactions. At the first order transition, the shorter Mn-Mn bonds exhibit an abrupt decrease in their length resulting in an antiferromagnetic ground state and a strained lattice.Comment: Accepted in J. Appl. Phys. Please contact authors for supplementary informatio

Performance and Irradiation Tests of the 0.3μ\mum CMOS TDC for the ATLAS MDT

ATLAS Muon TDC test-element group chip (AMTTEG) was developed and tested to confirm the performance of critical circuits of the TDC and measure radiation tolerance of the process. The chip was fabricated in a 0.3 mm CMOS Gate-Array technology. Measurements of critical elements of the chip such as the PLL, and data buffering circuits demonstrated adequate performance. The effect of gamma-ray irradiation, using a Co60 source, and neutron irradiation, using PROSPERO reactor in France, were also examined. The test results revealed radiation tolerance adequate for the operation of the circuits in the environment of the ATLAS MDT

Simple and Rapid Enzymatic Method for the Synthesis of Single-Strand Oligonucleotides Containing Trifluorothymidine

To investigate the mechanism of trifluorothymidine (TFT)-induced DNA damage, we developed an enzymatic method for the synthesis of single-strand oligonucleotides containing TFT-monophosphate residues. Sixteen-mer oligonucleotides and 14-mer 5′-phosphorylated oligonucleotides were annealed to the template of 25-mer, so as to empty one nucleotide site. TFT-triphosphate was incorporated into the site by DNA polymerase and then ligated to 5′-phosphorylated oligonucleotides by DNA ligase. The synthesized 31-mer oligonucleotides containing TFT residues were isolated from the 25-mer complementary template by denaturing polyacrylamide electrophoresis. Using these single-strand oligonucleotides containing TFT residues, the cleavage of TFT residues from DNA, using mismatch uracil-DNA glycosylase (MUG) of E.coli origin, was compared with that of 5-fluorouracil (5FU) and 5-bromodeoxyuridine (BrdU). The TFT/A pair was not cleaved by MUG, while the other pairs, namely, 5FU/A, 5FU/G, BrdU/A, BrdU/G, and TFT/G, were easily cleaved from each synthesized DNA. Thus, this method is useful for obtaining some site-specifically modified oligonucleotides

Efficacy of capillary pattern type IIIA/IIIB by magnifying narrow band imaging for estimating depth of invasion of early colorectal neoplasms

<p>Abstract</p> <p>Background</p> <p>Capillary patterns (CP) observed by magnifying Narrow Band Imaging (NBI) are useful for differentiating non-adenomatous from adenomatous colorectal polyps. However, there are few studies concerning the effectiveness of magnifying NBI for determining the depth of invasion in early colorectal neoplasms. We aimed to determine whether CP type IIIA/IIIB identified by magnifying NBI is effective for estimating the depth of invasion in early colorectal neoplasms.</p> <p>Methods</p> <p>A series of 127 consecutive patients with 130 colorectal lesions were evaluated from October 2005 to October 2007 at the National Cancer Center Hospital East, Chiba, Japan. Lesions were classified as CP type IIIA or type IIIB according to the NBI CP classification. Lesions were histopathologically evaluated. Inter and intraobserver variabilities were assessed by three colonoscopists experienced in NBI.</p> <p>Results</p> <p>There were 15 adenomas, 66 intramucosal cancers (pM) and 49 submucosal cancers (pSM): 16 pSM superficial (pSM1) and 33 pSM deep cancers (pSM2-3). Among lesions diagnosed as CP IIIA 86 out of 91 (94.5%) were adenomas, pM-ca, or pSM1; among lesions diagnosed as CP IIIB 28 out of 39 (72%) were pSM2-3. Sensitivity, specificity and diagnostic accuracy of the CP type III for differentiating pM-ca or pSM1 (<1000 μm) from pSM2-3 (≥1000 μm) were 84.8%, 88.7 % and 87.7%, respectively. Interobserver variability: κ = 0.68, 0.67, 0.72. Intraobserver agreement: κ = 0.79, 0.76, 0.75</p> <p>Conclusion</p> <p>Identification of CP type IIIA/IIIB by magnifying NBI is useful for estimating the depth of invasion of early colorectal neoplasms.</p