Gold(i)/Zn(ii) catalyzed tandem hydroamination/annulation reaction of 4-yne-nitriles

The tandem hydroamination-annulation reaction of 4-pentyne-nitriles in the presence of amine nucleophiles and a cooperatively operating catalyst system, consisting of Ph3PAuCl and Zn(ClO4)2, provides an efficient route to 2-aminopyrroles. Two regioisomeric 2-aminopyrroles were formed in moderate to good yields. © 2010 The Royal Society of Chemistry.TÜBİTAK; TÜBA and MET

EPR studies of intermolecular interactions and competitive binding of drugs in a drug-BSA binding model

Understanding intermolecular interactions between drugs and proteins is very important in drug delivery studies. Here, we studied different binding interactions between salicylic acid and bovine serum albumin (BSA) using electron paramagnetic resonance (EPR) spectroscopy. Salicylic acid was labeled with a stable radical (spin label) in order to monitor its mobilized (free) or immobilized (bound to BSA) states. In addition to spin labeled salicylic acid (SL-salicylic acid), its derivatives including SL-benzoic acid, SL-phenol, SL-benzene, SL-cyclohexane and SL-hexane were synthesized to reveal the effects of various drug binding interactions. EPR results of these SL-molecules showed that hydrophobic interaction is the main driving force. Whereas each of the two functional groups (-COOH and -OH) on the benzene ring has a minute but detectable effect on the drug-protein complex formation. In order to investigate the effect of electrostatic interaction on drug binding, cationic BSA (cBSA) was synthesized, altering the negative net charge of BSA to positive. The salicylic acid loading capacity of cBSA is significantly higher compared to that of BSA, indicating the importance of electrostatic interaction in drug binding. Moreover, the competitive binding properties of salicylic acid, ibuprofen and aspirin to BSA were studied. The combined EPR results of SL-salicylic acid/ibuprofen and SL-ibuprofen/salicylic acid showed that ibuprofen is able to replace up to ∼83% of bound SL-salicylic acid, and salicylic acid can replace only ∼14% of the bound SL-ibuprofen. This indicates that ∼97% of all salicylic acid and ibuprofen binding sites are shared. On the other hand, aspirin replaces only ∼23% of bound SL-salicylic acid, and salicylic acid replaces ∼50% of bound SL-aspirin, indicating that ∼73% of all salicylic acid and aspirin binding sites are shared. These results show that EPR spectroscopy in combination with the spin labeling technique is a very powerful method to investigate drug binding dynamics in detail.Turkish Scientific and Technological Research Council (2232-114C082

Fenilhidrazinlerin furan ve tiyofen ile mangan(III) asetat kullanılarak birleşmesi

A convenient new method for the arylation of furan and thiophene with arylhydrazine and manganese(III) acetate is described. Oxidation of arylhydrazines with Mn(III) acetate in furan or thiophene affords the corresponding 2-aryl-substituted furans and thiophenes in good yield using commercially available materials; access to 2-substituted heterobiaryls works selectively, and coupling occurs with loss of the hydrazine moiety.M.S. - Master of Scienc

A BODIPY-based reactive probe for the detection of Au(iii) species and its application to cell imaging

A BODIPY-based fluorescent probe bearing a pyridyl hydrazone motif responds selectively to Au(III) ions through an irreversible C[double bond, length as m-dash]N bond hydrolysis reaction. Gold species, besides their ability to catalyse chemical transformations in organic synthesis,1 have significant impacts on human health.2,3 Gold-based drugs have long been used in the treatment of rheumatoid arthritis and other autoimmune diseases.2 At the same time, when accumulated in the biological system at certain concentrations, gold species have the potential to disturb a series of cellular processes by irreversible interaction with biomolecules.3 In recent years, fluorescence-based sensing has become an indispensable tool for sensitive and accurate detection of trace levels of metal species in the solution.4 In addition, with the aid of fluorescence microscopy it has become possible to track metal species in living cells, which is of crucial importance for elucidating their roles in the biological system.Izmir Institute of Technology; TUBITAK (113Z601

Mermer artıklarında bağlayıcılar yardımıyla "Mermer Blokları" elde edilmesi

Son yillarda; mermere olan talebin artmasma paralel olarak mermer ocak isletrneleri ve mermer kesrne-islerne tesislerinin sayisi da surekli olarak yukselmistir. Bu sektorde gorulen buyume, dogal olarak ortaya cikan mermer arnklan miktannda da buyuk artrslara neden olmustur. Hem ocaklarda hem de tesislerde olusan ve kullarulamayacak boyutlardaki bu mermer artiklanrun yeniden degerlendirilerek ulkemiz ekonomisine kazandmlmasi; hem ekonomik olarak hemde cevre kirliligi acismdan kacmrlrnaz olarak gorulmektedir. Bu arnacla merrner. artrklanrun cesitli baglaytcrlar yardirruyla "suni blok mermer" haline donusturulmesi ve bu bloklardan istenilen ebatlarda plaka elde edilmesi arastmlrmstir. Bu makalede bu konuda yapilan cahsrnalardan bir bolurnu ozet olarak sunulrnaktadir

Mermer artıklarından polyester bağlayıcılı suni mermer blok ve levha üretiminin araştırılması.

Bu çalışmada; mermer ocakları ve işleme tesislerinde oluşan mermer atıklarının bağlayıcı olarak polyester kullanarak, mermer atıklarından oluşan ve plaka olarak kesilebilen blok üretimi konusu incelenmiştir. Çalışmada kullanılan mermer parçaları, kırma ve eleme işlemleri sonucunda tane gruplarına göre ayrılmış ve çeşitli tane boyutlarından oluşan 3 ayrı agrega grubu elde edilmiştir. Bağlayıcı olarak polyester değişik oranlarda kullanılmak suretiyle en uygun agrega/bağlayıcı oranı elde edilmeye çalışılmıştır. Agrega grupları ve polyesterin preslenmesi sonucu elde edilen plakaların, fiziksel ve mekanik özellikleri tespit edilerek standart değerler ile kıyaslanmıştır. Üretilen plakaların ağırlıkça su emmesi % 0,19, basınç mukavemeti ise 877 kg/cm2 olarak tespit edilmiş olup bu değerler standart değerlerin üzerindedir. Sonuç olarak bu yöntem ile doğal mermerin renk ve yapısına benzer özellikte, istenilen boyutlarda mermer plakaları üretmek mümkündür.In this study, it was investigated that the production of syntetich marble blocks and slabs by using waste of marble quarries and factories. Polyester were used as binder in the experiments. Marble particles, crushed and screened, were classified as dimension of grains. In this way, three different group of agrega was produced. Polyester were mixed at various ratios to the samples of the marble wastes, in order to find out the most suitable ratio of agrega/binder. Some of the mechanical and physical charecteristics of these products are too much under the ones of the naturel marble. However, some characteristics of slabs binded with polyester are nearly the ones of the naturel marble. For example, the water absorbtion % by weight of the samples binded with polyester are 0,19 % and compressive strenght of this is 877 kg/cm2. It is possible with this method to produce artificial marble blocks and slabs whose colors and structure are similar to the ones of the natural marble. The blocks can be produced with the all required dimensions

Mermer artıklarından polyester bağlayıcılı suni mermer blok ve levha üretiminin araştırılması.

Bu çalışmada; mermer ocakları ve işleme tesislerinde oluşan mermer atıklarının bağlayıcı olarak polyester kullanarak, mermer atıklarından oluşan ve plaka olarak kesilebilen blok üretimi konusu incelenmiştir. Çalışmada kullanılan mermer parçaları, kırma ve eleme işlemleri sonucunda tane gruplarına göre ayrılmış ve çeşitli tane boyutlarından oluşan 3 ayrı agrega grubu elde edilmiştir. Bağlayıcı olarak polyester değişik oranlarda kullanılmak suretiyle en uygun agrega/bağlayıcı oranı elde edilmeye çalışılmıştır. Agrega grupları ve polyesterin preslenmesi sonucu elde edilen plakaların, fiziksel ve mekanik özellikleri tespit edilerek standart değerler ile kıyaslanmıştır. Üretilen plakaların ağırlıkça su emmesi % 0,19, basınç mukavemeti ise 877 kg/cm2 olarak tespit edilmiş olup bu değerler standart değerlerin üzerindedir. Sonuç olarak bu yöntem ile doğal mermerin renk ve yapısına benzer özellikte, istenilen boyutlarda mermer plakaları üretmek mümkündür.In this study, it was investigated that the production of syntetich marble blocks and slabs by using waste of marble quarries and factories. Polyester were used as binder in the experiments. Marble particles, crushed and screened, were classified as dimension of grains. In this way, three different group of agrega was produced. Polyester were mixed at various ratios to the samples of the marble wastes, in order to find out the most suitable ratio of agrega/binder. Some of the mechanical and physical charecteristics of these products are too much under the ones of the naturel marble. However, some characteristics of slabs binded with polyester are nearly the ones of the naturel marble. For example, the water absorbtion % by weight of the samples binded with polyester are 0,19 % and compressive strenght of this is 877 kg/cm2. It is possible with this method to produce artificial marble blocks and slabs whose colors and structure are similar to the ones of the natural marble. The blocks can be produced with the all required dimensions

Mermer artıklarında bağlayıcılar yardımıyla "Mermer Blokları" elde edilmesi

Son yillarda; mermere olan talebin artmasma paralel olarak mermer ocak isletrneleri ve mermer kesrne-islerne tesislerinin sayisi da surekli olarak yukselmistir. Bu sektorde gorulen buyume, dogal olarak ortaya cikan mermer arnklan miktannda da buyuk artrslara neden olmustur. Hem ocaklarda hem de tesislerde olusan ve kullarulamayacak boyutlardaki bu mermer artiklanrun yeniden degerlendirilerek ulkemiz ekonomisine kazandmlmasi; hem ekonomik olarak hemde cevre kirliligi acismdan kacmrlrnaz olarak gorulmektedir. Bu arnacla merrner. artrklanrun cesitli baglaytcrlar yardirruyla "suni blok mermer" haline donusturulmesi ve bu bloklardan istenilen ebatlarda plaka elde edilmesi arastmlrmstir. Bu makalede bu konuda yapilan cahsrnalardan bir bolurnu ozet olarak sunulrnaktadir

A BODIPY-based fluorescent probe for ratiometric detection of gold ions: Utilization of: Z -enynol as the reactive unit

Using an irreversible intramolecular cyclisation pathway triggered by gold ions, a boron-dipyrromethene (BODIPY) based fluorescent probe integrated with a reactive Z-enynol motif responds selectively to gold ions. With the addition of gold(iii), the probe displays ratiometric fluorescence behaviour clearly observable to the naked eye under both visible and UV light. © The Royal Society of Chemistry 2016.Izmir Institute of Technology; TUBITAK (113Z601

Investigation of the production of syntetich marble blocks and slabs with polyester binder by using waste of marble

Çalışmada kullanılan mermer parçalan, kırma ve eleme işlemleri sonucunda tane gruplarına göre ayrılmış ve çeşitli tane boyutlarından oluşan 3 ayrı agrega grubu elde edilmiştir. Bağlayıcı olarak polyester değişik oranlarda kullanılmak suretiyle en uygun agrega/bağlayıcı oranı elde edilmeye çalışılmıştır. Agrega grupları ve polyesterin preslenmesi sonucu elde edilen plakaların, fiziksel ve mekanik özellikleri tespit edilerek standart değerler ile kıyaslanmıştır. Üretilen plakaların ağırlıkça su emmesi % 0,19, basınç mukavemeti ise 877 kg/cm2 olarak tespit edilmiş olup bu değerler standart değerlerin üzerindedir. Sonuç olarak bu yöntem ile doğal mermerin renk ve yapısına benzer özellikte, istenilen boyutlarda mermer plakaları üretmek mümkündür