Increased serum levels of NMDA receptor antibodies in female patients with bipolar disorder

Objective: Glutamatergic/GABAergic imbalance due to autoimmune antibodies targeting N-methyl-D-aspartate receptors (NMDA-R) is considered to be one of the shared pathways between bipolar disorder (BD) and autoimmune diseases. Evidence shows female vulnerability to autoimmune disorders, and suggests a sex-specific approach in autoimmunity research in BD. We aimed to assess serum concentrations of NMDA-R antibodies and density of NMDA and GABA receptors on platelets in euthymic patients with BD in comparison to healthy individuals; and to determine the impact of sex on serum concentrations of NMDA-R antibodies and the density of NMDA and GABA receptors on platelets. Method: NMDA antibody IgG were detected in serum samples of 27 DSM IV euthymic patients with bipolar disorder (16 females, 11 males) and 33 healthy individuals (17 females, 16 males), using ELISA method. The densities of NMDA and GABA receptors on platelets were investigated using immunocytochemical methods. Results: Patients with BD presented higher serum levels of NMDA-R antibodies in comparison to healthy individuals (p<0.001). The densities of NMDA and GABA receptor on platelets were similar in both groups. The NMDA-R antibody levels were influenced by both diagnosis and sex (F=5.813, df=1, p =0.020). Tserum lithium levels showed a significant linear association with the serum NMDA-R antibody levels even adjusting for age, sex, body mass index (F=-56.26, t=-2.52, p = 0.015, CI: -101.12/-11.40). Discussion: Our findings support a potential role of NMDA-R antibodies in the underlying pathophysiology of BD, particularly for females

The concept of schizotypy and schizotypal personality disorder

Schizophrenia is a disorder that consists of positive, negative symptoms, cognitive impairment, disorganization and various dimensions and manifested as several clinical appearances because of different intersections of these dimensions at different levels. The description of the schizophrenia-like clinical picture is based primarily on the finding that psychosis-like symptoms have accumulated in families of patients with schizophrenia. The following studies have examined paranoid, schizoid and schizotypal personality disorders in this spectrum by comparing them to schizophrenia. The idea intensely becomes more dominant in the literature that especially schizotypal personality disorder (SPD) is a non-progressive schizophrenia spectrum disorder in which different dimensions of schizotypy are seen together rather than a personality disorder. Among the personality disorders, SPD has the strongest genetic relationship with schizophrenia. The term schizotypy was first described as a schizophrenia-like psychosis phenotype. To date, studies have shown schizotypy has different dimensions, such as schizophrenia, and that reflections of these dimensions are common in non-clinical populations and individuals at risk for psychosis. At the same time, several studies found related dimensions of schizophrenia and schizotypy have similar neurobiological bases. As per the definiton of prodrome is a condition can only be defined retrospectively in patients with schizophrenia. Therefore, schizotypal personality disorder and high schizotypy are predisposition indicators within the spectrum rather than reflecting the schizophrenia prodrome. Identifying of these borderline cases is important for uncovering etiopathogenesis of psychosis, early diagnosis of schizophrenia, intervention to predisposing factors and prevention of psychotic break

THE BRIEF RESIDENT WELLNESS PROFILE: VALIDITY AND RELIABILITY OF TURKISH VERSION

Objective: We aimed to construct a valid and reliable Turkish version of the Brief Resident Wellness Profile (BRWP), which was developed by Keim et al. in 2006 to evaluate resident physicians' wellness regularly and easily in their busy working environment

Relationship between social-cognitive and social-perceptual aspects of theory of mind and neurocognitive deficits, insight level and schizotypal traits in obsessive-compulsive disorder

Objective: The primary aim of the current study was to investigate different aspects of theory of mind (ToM), including social-cognitive (ToM-reasoning) and social-perceptual (ToM-decoding) in obsessive-compulsive disorder (OCD). We also aimed to investigate the relationship between ToM, neurocognition and a number of clinical variables including overvalued ideas, schizotypal personality traits, level of insight, and disease severity

Synthesis, Characterization of a New Polyacrylic Acid Superabsorbent, Some Heavy Metal Ion Sorption, the Adsorption Isotherms, and Quantum Chemical Investigation

Poly(acrylic acid/Kryptofix 23-Dimethacrylate) superabsorbent polymer [P (AA/Kry23-DM) SAP] was synthesized by solution polymerization to remove Co, Ni, Cu, Cd, Mn, Zn, Pb, Cr, and Fe ions in water and improve the quality of the water. Kry23-DM cross-linker (1,4,7,13,16-Pentaoxa-10,19 diazo cyclohexene icosane di methacrylate) was synthesized using Kry23 and methacryloyl chloride. The characterization of the molecules was done by FTIR, TGA, DSC, and SEM techniques. The effects of parameters such as pH, concentration, and the metal ion interaction on the heavy metal ions uptaking of SAP was investigated. It was observed that P (AA/Kry23-DM) SAP has maximum water absorption, and the absorption increases with the pH increase. Adsorption rates and sorption capacity, desorption ratios, competitive sorption (qcs), and distribution coefficient (log D) of P(AA/Kry23-DM) SAP were studied as a function of time and pH with the heavy metal ion concentration. Langmuir and Freundlich isotherms of the P (AA/Kry23-DM) SAP were investigated to verify the metal uptake. Molecular mechanic (MM2), Assisted Model Building with Energy Refinement (AMBER), and optimized potentials for liquid simulations (OPLS) methods. were used in quantum chemical calculations for the conformational analysis of the cross-linker and the SAP. &Delta;H0f calculations of the cross-linker and the superabsorbent were made using Austin Model 1(AM1) method

Comparison of acetabulum posterior wall fractures and fracture dislocations: Dislocation does not affect clinical and radiological outcomes

© 2018 acta Orthopaedica Belgica.The aim of this study was to compare radiological and clinical outcomes of posterior wall acetabulum fractures and posterior wall fracture dislocations. Data were including 52 acetabulum fractures and fracture dislocations. Twenty-six patients (%50) had posterior acetabulum fractures and fracture dislocations who were operatively treated. Radiographic evaluations were performed before and after the operation and at the last follow up. Clinical outcome evaluation was performed at the last follow up. Clinical and radiological outcomes were evaluated including Merle D’aubigne clinical assessment score and Matta’ s radiologic measurement score. Brooker classification was used to measure heterotopic ossification. Both Merle D’aubigne and Matta scores were found higher in the acetabulum posterior wall fracture group. But there wasn’t significantly difference of clinical and radiological outcomes between two groups (p > 0,05). Reduction quality and Matta radiologic scores were correlated significantly in 2 groups. Posterior dislocation may not negatively affect clinical and radiologic outcomes

Comparison of acetabulum posterior wall fractures and fracture dislocations: Dislocation does not affect clinical and radiological outcomes

© 2018, Acta Orthopaedica Belgica.The aim of this study was to compare radiological and clinical outcomes of posterior wall acetabulum fractures and posterior wall fracture dislocations. Data were including 52 acetabulum fractures and fracture dislocations. 26 patients (%50) had posterior acetabulum fractures and fracture dislocations who were operatively treated. Radiographic evaluations were performed before and after the operation and at the last follow up. Clinical outcome evaluation was performed at the last follow up. Clinical and radiological outcomes were evaluated including Merle D'aubigne clinical assessment score and Matta' s radiologic measurement score. Brooker classification was used to measure heterotopic ossification.Both Merle D'aubigne and Matta scores were found higher in the acetabulum posterior wall fracture group. But there wasn't significantly difference of clinical and radiological outcomes between two groups (p . 0,05). Reduction quality and Matta radiologic scores were correlated significantly in 2 groups. Posterior dislocation may not negatively affect clinical and radiologic outcomes