Peptide-directed co-assembly of nanoprobes on multimaterial patterned solid surfaces

This is the published version. Copyright 2012 Royal Society of ChemistryBiocombinatorially selected solid-binding peptides, through their unique material affinity and selectivity, are a promising platform for building up complex hierarchical assemblies of nanoscale materials and molecular probes, targeted to specific practical solid surfaces. Here, we demonstrate the material-specific characteristics of engineered gold-binding and silica-binding peptides through co-assembly onto micro- and nano-patterned gold surfaces on silica substrates. To build hierarchical nanostructures on patterned solid surfaces, we utilize peptides as molecular tools and monitor their behavior by either conjugating biotin to them for specific affinity to streptavidin-coated QDot nanoparticles or labelling them with small fluorescent labels. This biomimetic peptide-based approach could be used as an alternative to conventional chemical coupling and surface functionalization techniques with substantial advantages, allowing simultaneous assembly of two or more inorganic nano-entities and/or molecular probes onto patterned inorganic solid substrates. The results have significant implications in a wide range of potential applications, including controlled assembly of hybrid nanostructures in bionanophotonic and biosensing devices

Magnetic resonance imaging study of corpus callosum abnormalities in patients with different subtypes of schizophrenia

Background. Reductions in the size of the corpus callosum (CC) have been described for schizophrenia patients, but little is known about the possible regional differences in schizophrenia subtypes (paranoid, disorganised, undifferentiated, residual).  Methods. We recruited 58 chronically schizophrenic patients with different subtypes, and 31 age-and-gender matched healthy controls. The callosum was extracted from a midsagittal slice from T1 weighted magnetic resonance images, and areas of the total CC, its five subregions, CC length and total brain volume were compared between schizophrenia subtypes and controls. Five subregions were approximately matched to fibre pathways from cortical regions.  Results. Schizophrenia patients had reduced CC total area and length when compared with controls. Disorganised and undifferentiated schizophrenics had a smaller prefrontal area, while there was no significant difference for the paranoid and residual groups. The premotor/supplementary motor area was smaller in all schizophrenia subtypes. The motor area was smaller only in the disorganised group. A smaller sensory area was found in all subtypes except the residual group. Parietal, temporal and occipital areas were smaller in the paranoid and undifferentiated groups. Total brain volume was smaller in all schizophrenia subtypes compared with controls, but did not reach statistical significance.  Conclusion. These findings suggest that the heterogeneity of symptoms may lead to the different CC morphological characteristics in schizophrenia subtypes

Robotic Timber Construction - Studie über Robotik-Fertigungsmethoden von computergestützten Holzkonstruktionen

Abweichender Titel nach Übersetzung der Verfasserin/des VerfassersDiese Diplomarbeit untersucht die Bedeutung der digitalen Fabrikation und robotische Holzkonstruktionen anhand des historischen Hintergrunds der digitalen Fabrikation. Verschiedene Methoden der digitalen Fertigung werden erforscht, analysiert und aufgrund ihrer Vor- und Nachteile bewertet. Denn seit langer Zeit-CNC-Fräsen oder -Schneiden war bereits in der Industrie im Einsatz und fand seinen Weg in die Architektur. Auch in der Automobilindustrie wurden Roboterarme eingesetzt, die jedoch darauf programmiert waren, ein Leben lang einen Job zu erledigen. Das rechnergestützte Design ermöglichte die Verwendung dieser flexiblen und präzisen Werkzeuge zur Herstellung von Freiformkörpern. Roboterarme haben eine Vielzahl von Vorteilen, wie beispielsweise die Flexibilität in ihrer Bewegung, da sie nicht in einem kubischen Arbeitsraum arbeiten. Neben der Tatsache, dass sie nicht nur an einem Werkzeug befestigt sind, kann der Endeffektor jede Art von Arbeitswerkzeug sein. Der Roboterarm kann jede digitale Fertigungsmethode ausführen, angefangen von der additiven Methode bis zur subtraktiven Methode. Dies hängt vom Endeffektor ab, der am Roboter angebracht ist. Das rechnerische Design ist ein großer Meilenstein, da mit dem Roboterarm komplexe Formen und Geometrien hergestellt werden können. Das natürliche Bauprodukt Holz ist ein Material, das für die rechnergestützte Konstruktion nicht einfach zu handhaben ist, aber Forscher auf der ganzen Welt haben verschiedene neue Methoden zur Herstellung von Robotern erfunden, die die rechnergestützte Konstruktion von Holzprodukten ermöglichen. In dieser Forschungsarbeit werden das rechnergestützte Design von Holzstrukturen und die neuen Methoden der Roboterherstellung analysiert. Mit den gewonnenen Erkenntnissen wird es in Shanghai ein mittelgroßes Designprojekt im M50 Creativity Park mit Bauholz geben. Der Herstellungsprozess wird simuliert und parametrisch ausgelegt.This thesis researches the importance of digital fabrication and robotic timber constructions through analysing the historical background of digital fabrication. Different methods of digital fabrication will be researched and analysed and evaluated due to their advantages and disadvantages. Since a long-term CNC milling or cutting was already in use by industries and found its way to architecture. As well robotic arms were used in the automotive industry, but they were programmed to do one job for a lifetime. The computational design made it possible to use this flexible and precise tools to fabricate freeforms. Robotic arms have a high amount of advantages such as the flexibility in their movement, since they are not working in a cubic working space. As well the fact that they are not just attached to one tool, the end effector can be any kind of working tool. The robotic arm can execute every digital fabrication method started from additive method till to subtractive method, it depends on the end effector which is attached to the robot. The computational design is a huge milestone because of this, complex shapes and geometries can be fabricated with the robotic arm. The natural building product timber is a material which is not easy to manipulate for computational design but researchers around the globe invented different new methods for robotic fabrication which makes the computational design for timber products possible. In this research computational design of timber structures and the new methodologies of robotic fabrication will be analysed and with gained knowledge there will be a mid-scale design project in Shanghai at the M50 Creativity Park with construction timber. The fabrication process will be simulated and designed parametrically.11

An extremely rare cause of generalized lymphadenopathy in children: Kimura's disease

Kimura's disease, characterized by a triad of painless subcutaneous masses in the head and neck, prominent eosinophilia and markedly elevated immunoglobulin E levels, is an uncommon idiopathic, chronic inflammatory disease that usually affects young and middle-aged Asian males. Kimura's disease is known usually as a localized process and is an extremely rare cause of generalized lymphadenopathy in children. We report an eight-year-old Turkish boy with Kimura's disease who presented with generalized lymphadenopathy masquerading as malignant lymphoma

Noise Minimization in CMOS Current Mode Circuits That Employ Differential Input Stage

In this paper, a new noise minimization approach is proposed for CMOS current-mode (CM) circuits whose input stage is differential. This is realized by focusing on input stage and some output stage transistors' transconductance. Effect of output stage over the noise model depends on output stage's operation. This minimization is introduced to designers as a trade-off between design parameters and noise reduction. Analyses are presented in basis of Differential Difference Current Conveyor (DDCC) for simplicity. To reinforce theoretical concept, simulation results are given both in schematic and layout based. Moreover, a DDCC filter application, which has single input and four outputs is presented to verify theoretical minimization approach. After minimization, it is shown that significant noise reduction is obtained up to 50%. In addition, Monte Carlo analysis is given in order to investigate process variations and temperature effects on measured input referred noise

Electronically tunable MOSFET-only current-mode biquad filter

A novel current mode MOSFET-only structure with multi-input single-output (MISO) is proposed. The proposed circuit is free from passive circuit elements like resistors and capacitors and able to realize low-pass (LP), band-pass (BP), high-pass (HP), band-stop (BS) and all-pass (AP) filter functions with using the same circuit configuration. It is also important to note that the proposed filter has electronic tunability property. The proposed circuit is laid-out in the Cadence environment using 0.18 mu m TSMC CMOS technology parameters. The layout area is only 408 mu m(2) and the power consumption is about 0.6 mW. Furthermore, to investigate the performance of the BP filter output of the proposed MISO filter, Monte Carlo and corner analyses are also presented. It is shown that the mismatches and the process variations cause only small deviations for the BP filter configuration. Furthermore, the noise performance of the proposed filter is also investigated. (C) 2017 Elsevier GmbH. All rights reserved

Rare use of twin Solitaire® stents in the double waffle-cone technique for endovascular treatment of a wide-necked bifurcation aneurysm

exterior, View of cathedral and adjoining buildings on wall, 199

Grisel’s Syndrome: A Rare Complication following Adenotonsillectomy

Grisel’s syndrome is a nontraumatic atlantoaxial subluxation which is usually secondary of an infection or an inflammation at the head and neck region. It can be observed after surgery of head and neck region. Etiopathogenesis has not been clearly described yet, but increased looseness of paraspinal ligament is thought to be responsible. Patients typically present with painful torticollis. Diagnosis of Grisel’s syndrome is largely based on suspicion of the patient who has recently underwent surgery or history of infection in head and neck region. Physical examination and imaging techniques assist in diagnosis. Therefore, clinicians should be aware of acute nontraumatic torticollis after recently applied the head and neck surgery or undergone upper respiratory tract infection. In this paper, a case of an eight-year-old male patient who had Grisel’s syndrome after adenotonsillectomy is discussed with review of the literature