4 research outputs found
Practical Synthesis of Unsymmetrical Tetraarylethylenes and Their Application for the Preparation of [TriphenylethyleneâSpacerâTriphenylethylene] Triads
We have demonstrated that reactions of diphenylmethyllithium with a variety of substituted benzophenones produces corresponding tertiary alcohols that are easily dehydrated, without any need for purification, to produce various unsymmetrical and symmetrical tetraarylethylenes in excellent yields. The simplicity of the method allows for the preparation of a variety of ethylenic derivatives in multigram (10â50 g) quantities with great ease. The methodology was successfully employed for the preparation of various triphenylethylene (TPE)-based triads (i.e., TPEâspacerâTPE) containing polyphenylene and fluoranyl-based spacers. The ready availability of various substituted tetraarylethylenes allowed us to shed light on the effect of substituents on the oxidation potentials (Eox) of various tetraarylethylenes. Moreover, the electronic coupling among the triphenylethylene moieties in various TPEâspacerâTPE triads was briefly probed by electrochemical and optical methods
Analysis of Seven-Membered Lactones by Computational NMR Methods: Proton NMR Chemical Shift Data are More Discriminating than Carbon
We report an NMR
chemical shift study of conformationally challenging
seven-membered lactones (<b>1</b>â<b>11</b>); computed
and experimental data sets are compared. The computations involved
full conformational analysis of each lactone, Boltzmann-weighted averaging
of the chemical shifts across all conformers, and linear correction
of the computed chemical shifts. DFT geometry optimizations [M06-2X/6-31+GÂ(d,p)]
and GIAO NMR chemical shift calculations [B3LYP/6-311+GÂ(2d,p)] provided
the computed chemical shifts. The corrected mean absolute error (CMAE),
the average of the differences between the computed and experimental
chemical shifts for each of the 11 lactones, is encouragingly small
(0.02â0.08 ppm for <sup>1</sup>H or 0.8â2.2 ppm for <sup>13</sup>C). Three pairs of <i>cis</i> versus <i>trans</i> diastereomeric lactones were used to assess the ability of the method
to distinguish between stereoisomers. The experimental shifts were
compared with the computed shifts for each of the two possible isomers.
We introduce the use of a âmatch ratioâî¸the ratio
of the larger CMAE (worse fit) to the smaller CMAE (better fit). A
greater match ratio value indicates better distinguishing ability.
The match ratios are larger for proton data [2.4â4.0 (av =
3.2)] than for carbon [1.1â2.3 (av = 1.6)], indicating that
the former provide a better basis for discriminating these diastereomers