The Cauchy Problem for a One Dimensional Nonlinear Peridynamic Model

This paper studies the Cauchy problem for a one-dimensional nonlinear peridynamic model describing the dynamic response of an infinitely long elastic bar. The issues of local well-posedness and smoothness of the solutions are discussed. The existence of a global solution is proved first in the sublinear case and then for nonlinearities of degree at most three. The conditions for finite-time blow-up of solutions are established.Comment: To appear in Journal of Differential Equations (added references, corrected typos, minor revision in Section 2, 18 pages

The Cauchy Problem for a One Dimensional Nonlinear Peridynamic Model

This paper studies the Cauchy problem for a one-dimensional nonlinear peridynamic model describing the dynamic response of an infinitely long elastic bar. The issues of local well-posedness and smoothness of the solutions are discussed. The existence of a global solution is proved first in the sublinear case and then for nonlinearities of degree at most three. The conditions for finite-time blow-up of solutions are established.Comment: To appear in Journal of Differential Equations (added references, corrected typos, minor revision in Section 2, 18 pages

Purification and analytical characterization of an anti- CD4 monoclonal antibody for human therapy

A purification process for the monclonal anti-CD4 antibody MAX.16H5 was developed on an analytical scale using (NH&SO, precipitation, anion-exchange chromatography on MonoQ or Q-Sepharose, hydrophobic interaction chromatography on phenyl- Sepharose and gel filtration chromatography on Superdex 200. The purification schedule was scaled up and gram amounts of MAX.16H5 were produced on corresponding BioPilot columns. Studies of the identity, purity and possible contamination by a broad range of methods showed that the product was highly purified and free from contaminants such as mouse DNA, viruses, pyrogens and irritants. Overall, the analytical data confirm that the monoclonal antibody MAX.16H5 prepared by this protocol is suitable for human therapy

Facilitators and barriers to the implementation of a Mobile Health Wallet for pregnancy-related health care: A qualitative study of stakeholders’ perceptions in Madagascar

Financial barriers are a major obstacle to accessing maternal health care services in low-resource settings. In Madagascar, less than half of live births are attended by skilled health staff. Although mobile money-based savings and payment systems are often used to pay for a variety of services, including health care, data on the implications of a dedicated mobile money wallet restricted to health-related spending during pregnancy–a mobile health wallet (MHW)–are not well understood. In cooperation with the Madagascan Ministry of Health, this study aims to elicit the perceptions, experiences, and recommendations of key stakeholders in relation to a MHW amid a pilot study in 31 state-funded health care facilities. We conducted a two-stage qualitative study using semi-structured in-depth interviews with stakeholders (N = 21) representing the following groups: community representatives, health care providers, health officials and representatives from phone provider companies. Interviews were conducted in Atsimondrano and Renivohitra districts, between November and December of 2017. Data was coded thematically using inductive and deductive approaches, and found to align with a social ecological model. Key facilitators for successful implementation of the MHW, include (i) close collaboration with existing communal structures and (ii) creation of an incentive scheme to reward pregnant women to save. Key barriers to the application of the MHW in the study zone include (i) disruption of informal benefits for health care providers related to the current cash-based payment system, (ii) low mobile phone ownership, (iii) illiteracy among the target population, and (iv) failure of the MHW to overcome essential access barriers towards institutional health care services such as fear of unpredictable expenses. The MHW was perceived as a potential solution to reduce disparities in access to maternal health care. To ensure success of the MHW, direct demand-side and provider-side financial incentives merit consideration

Natural History Of Atopic Disease In Early Childhood: Is Cord Blood IgE A Prognostic Factor?

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/68008/2/10.1177_000992289203100411.pd

The Egorov theorem for transverse Dirac type operators on foliated manifolds

Egorov's theorem for transversally elliptic operators, acting on sections of a vector bundle over a compact foliated manifold, is proved. This theorem relates the quantum evolution of transverse pseudodifferential operators determined by a first order transversally elliptic operator with the (classical) evolution of its symbols determined by the parallel transport along the orbits of the associated transverse bicharacteristic flow. For a particular case of a transverse Dirac operator, the transverse bicharacteristic flow is shown to be given by the transverse geodesic flow and the parallel transport by the parallel transport determined by the transverse Levi-Civita connection. These results allow us to describe the noncommutative geodesic flow in noncommutative geometry of Riemannian foliations.Comment: 27 pages, to appear in Journal of Geometry and Physic

Elution study of acrylic monomers from orthodontic materials using high performance liquid chromatography (HPLC)

Purpose: Main goal of the study was the identification and quantitative analysis of monomer elution from materials commonly used in fixed orthodontic therapy. Studies have shown severe health effects of monomers including cytotoxic, allergenic or mutagenic potential and endocrine changes. This in vitro study focusses primarily on five resins which are usually processed intraorally and remain in the oral cavity long-term. Methods: We tested the elution of monomers from specimens (7.5 mm x 1.5 mm) immersed in artificial saliva at body temperature (37 degrees C) for 30 min to 5 weeks. The used method is in accordance with DIN EN ISO 10993-13. The five tested materials were BrackFix (R) (Voco GmbH, Cuxhaven, Germany), Triad (R) Gel (DeguDent GmbH, Hanau, Germany), and Transbond (TM) XT, LR and Plus (3M Unitek, Monrovia, CA, USA). All aliquots were analyzed using high performance liquid chromatography (HPLC). Data were statistically analyzed. Results: All five analyzed materials eluted substances over a period of 5 weeks. Identified substances included bisphenol A (BPA), triethylene glycol dimethacrylate (TEGDMA) and urethane dimethacrylate (UDMA). BPA eluted from Transbond (TM) Plus, XT, LR and BrackFix (R). The cumulated mean values after 35 days ranged from 16.04 to 64.83 ppm, depending on the material. TEGDMA eluted with a mean of 688.61 ppm from Transbond (TM) LR. UDMA with a mean of 1682.00 ppm from Triad (R) Gel. For each material the highest concentrations of all these substances were found in the first elution period. Other substances that were not equivocally identified or of low concentration also eluted. Conclusion: Using the described method, it is possible to qualitatively and quantitatively determine the in vitro elution of monomers from orthodontic materials. The concentrations of the substances identified were below the current maximum recommended intake. However, a cumulative effect and low-dose effects should be considered for both patients and dental professionals, especially for young patients. Measures to reduce exposure patients and practitioners are suggested

Direct Detection of Electroweak-Interacting Dark Matter

Assuming that the lightest neutral component in an SU(2)L gauge multiplet is the main ingredient of dark matter in the universe, we calculate the elastic scattering cross section of the dark matter with nucleon, which is an important quantity for the direct detection experiments. When the dark matter is a real scalar or a Majorana fermion which has only electroweak gauge interactions, the scattering with quarks and gluon are induced through one- and two-loop quantum processes, respectively, and both of them give rise to comparable contributions to the elastic scattering cross section. We evaluate all of the contributions at the leading order and find that there is an accidental cancellation among them. As a result, the spin-independent cross section is found to be O(10^-(46-48)) cm^2, which is far below the current experimental bounds.Comment: 19 pages, 7 figures, published versio