Coverings in p-adic analytic geometry and log coverings II: Cospecialization of the p'-tempered fundamental group in higher dimensions

This paper constructs cospecialization homomorphisms between the (p') versions of the tempered fundamental group of the fibers of a smooth morphism with polystable reduction (the tempered fundamental group is a sort of analog of the topological fundamental group of complex algebraic varieties in the p-adic world). We studied the question for families of curves in another paper. To construct them, we will start by describing the pro-(p') tempered fundamental group of a smooth and proper variety with polystable reduction in terms of the reduction endowed with its log structure, thus defining tempered fundamental groups for log polystable varieties

Epidemiology of gastric cancers and the role of Helicobacter pylori

Le risque de cancer de l’estomac est associé à la présence d’une gastrite chronique atrophique avec achlorhydrie, généralement associée à une infection par une bactérie commensale, l’Helicobacter pylori (H. pylori). Ce facteur de risque est au centre de l’étude du rôle du milieu environnant et des habitudes alimentaires

First steps toward finding relevant pathology-gene pairs using analogy

International audienceThis paper presents a first study to infer pathology-gene relation instances using analogy. The meaning of this relation between a pathology P and a gene G is "A mutation of G in a person can cause the appearance of pathology P for this person." In this work, a pathology is represented by a set of classes from HPO, the Human Phenotype Ontology, whereas a gene is represented similarly, but using GO, the Gene Ontology. Some (P, G) instances of the pathology-gene relations are known and the idea is to use analogical reasoning to infer new relations. The schema of the inference is as follows: if a target pathology P is in analogy with three other pathologies PA, PB and PC for which associated genes GA, GB and GC are known, then it is plausible that the gene G, to be associated with P, is in analogy with GA, GB, GC. This idea has proven to be fruitful in other domains, such as machine translation. The preliminary question explored in this paper is the following: given four pathologies PA, PB, PC and PD in analogy and for which the associated genes GA, GB, GC and GD are known, are thess genes in analogy, or, at least, in approximate analogy? Results of a large scale analysis (4, 000 (P, G) pairs) reveal that the quadruples of genes associated with quadruples of pathologies in analogy do not display statistically different analogical dissimilarity values than randomly selected quadruples of genes. Nevertheless very low analogical dissimilarity values are found in a small subset of gene quadruples that are specifically associated with pathologies in analogy. Analysis of these quadruples may allow us to learn more sophisticated analogical relations on genes in order to improve the recovery of pathology-gene pairs using analogy

Compliance with the current recommendations for prescribing antibiotics for paediatric community-acquired pneumonia is improving: data from a prospective study in a French network

International audienceBACKGROUND: Lower respiratory tract infection is a common cause of consultation and antibiotic prescription in paediatric practice. The misuse of antibiotics is a major cause of the emergence of multidrug-resistant bacteria. The aim of this study was to evaluate the frequency, changes over time, and determinants of non-compliance with antibiotic prescription recommendations for children admitted in paediatric emergency department (PED) with community-acquired pneumonia (CAP).METHODS: We conducted a prospective two-period study using data from the French pneumonia network that included all children with CAP, aged one month to 15 years old, admitted to one of the ten participating paediatric emergency departments. In the first period, data from children included in all ten centres were analysed. In the second period, we analysed children in three centers for which we collected additional data. Two experts assessed compliance with the current French recommendations. Independent determinants of non-compliance were evaluated using a logistic regression model. The frequency of non-compliance was compared between the two periods for the same centres in univariate analysis, after adjustment for confounding factors.RESULTS: A total of 3034 children were included during the first period (from May 2009 to May 2011) and 293 in the second period (from January to July 2012). Median ages were 3.0 years [1.4-5] in the first period and 3.6 years in the second period. The main reasons for non-compliance were the improper use of broad-spectrum antibiotics or combinations of antibiotics. Factors that were independently associated with non-compliance with recommendations were younger age, presence of risk factors for pneumococcal infection, and hospitalization. We also observed significant differences in compliance between the treatment centres during the first period. The frequency of non-compliance significantly decreased from 48 to 18.8 % between 2009 and 2012. The association between period and non-compliance remained statistically significant after adjustment for confounding factors. Amoxicillin was prescribed as the sole therapy significantly more frequently in the second period (71 % vs. 54.2 %, p < 0.001).CONCLUSIONS: We observed a significant increase in the compliance with recommendations, with a reduction in the prescription of broad-spectrum antibiotics, efforts to improve antibiotic prescriptions must continue

Entrer en résonance : Vibrations autour d'un monde commun à partir de rencontres entre le 9e art et la science

What if comics allowed us to understand scientific knowledge (production) differently? Some comics, beyond their aesthetic and playful aspects, raise numerous political, ethical and societal questions that directly resonate with social science work. As part of this ‘making and doing activity’, our goal is to address sociotechnical issues, with the help of comic book writers and other artists, and to collectively rebuild spaces for collective reflection on, and engagement in, open-ended technological futures

A New Malaria Agent in African Hominids

Plasmodium falciparum is the major human malaria agent responsible for 200 to 300 million infections and one to three million deaths annually, mainly among African infants. The origin and evolution of this pathogen within the human lineage is still unresolved. A single species, P. reichenowi, which infects chimpanzees, is known to be a close sister lineage of P. falciparum. Here we report the discovery of a new Plasmodium species infecting Hominids. This new species has been isolated in two chimpanzees (Pan troglodytes) kept as pets by villagers in Gabon (Africa). Analysis of its complete mitochondrial genome (5529 nucleotides including Cyt b, Cox I and Cox III genes) reveals an older divergence of this lineage from the clade that includes P. falciparum and P. reichenowi (∼21±9 Myrs ago using Bayesian methods and considering that the divergence between P. falciparum and P. reichenowi occurred 4 to 7 million years ago as generally considered in the literature). This time frame would be congruent with the radiation of hominoids, suggesting that this Plasmodium lineage might have been present in early hominoids and that they may both have experienced a simultaneous diversification. Investigation of the nuclear genome of this new species will further the understanding of the genetic adaptations of P. falciparum to humans. The risk of transfer and emergence of this new species in humans must be now seriously considered given that it was found in two chimpanzees living in contact with humans and its close relatedness to the most virulent agent of malaria

A simplified table using validated diagnostic criteria is effective to improve characterization of colorectal polyps: the CONECCT teaching program

International audienceIntroduction and study aims Accurate real-time endoscopic characterization of colorectal polyps is key to choosing the most appropriate treatment. Mastering the currently available classifications is challenging. We used validated criteria for these classifications to create a single table, named CONECCT, and evaluated the impact of a teaching program based on this tool.Methods A prospective multicenter study involving GI fellows and attending physicians was conducted. During the first session, each trainee completed a pretest consisting in histological prediction and choice of treatment of 20 colorectal polyps still frames. This was followed by a 30-minute course on the CONECCT table, before taking a post-test using the same still frames reshuffled. During a second session at 3 – 6 months, a last test (T3 M) was performed, including these same still frames and 20 new ones.Results A total 419 participants followed the teaching program between April 2017 and April 2018. The mean proportion of correctly predicted/treated lesions improved significantly from pretest to post-test and to T3 M, from 51.0 % to 74.0 % and to 66.6 % respectively (P < 0.001). Between pretest and post-test, 343 (86.6 %) trainees improved, and 153 (75.4 %) at T3 M. Significant improvement occurred for each subtype of polyp for fellows and attending physicians. Between the two sessions, trainees continued to progress in the histology prediction and treatment choice of polyps CONECCT IIA. Over-treatment decreased significantly from 30.1 % to 15.5 % at post-test and to 18.5 % at T3 M (P < 0.001).Conclusion The CONECCT teaching program is effective to improve the histology prediction and the treatment choice by gastroenterologists, for each subtype of colorectal polyp