8,543 research outputs found
Abundances of PNe in the Outer Disk of M31
We present spectroscopic observations and chemical abundances of 16 planetary
nebulae (PNe) in the outer disk of M31. The [O III] 4363 line is detected in
all objects, allowing a direct measurement of the nebular temperature essential
for accurate abundance determinations. Our results show that the abundances in
these M31 PNe display the same correlations and general behaviors as Type II
PNe in the Milky Way Galaxy. We also calculate photoionization models to derive
estimates of central star properties. From these we infer that our sample PNe,
all near the peak of the Planetary Nebula Luminosity Function, originated from
stars near 2 M_sun. Finally, under the assumption that these PNe are located in
M31's disk, we plot the oxygen abundance gradient, which appears shallower than
the gradient in the Milky Way.Comment: 48 pages, including 12 figures and 8 tables, accepted by
Astrophysical Journa
A real-time PCR method for quantification of the total and major variant strains of the Deformed wing virus
Funding: ELB was supported by a Biotechnology and Biological Sciences Research Council (BBSRC) EASTBIO Doctoral Training Partnership (http://www.bbsrc.ac.uk) [grant number BB/J01446X/1] and an Eastern Association Regional Studentship (EARS) and The Morley Agricultural Foundation awarded to ASB. CRC was supported by a KTN BBSRC CASE studentship (BB/M503526/1) (http://www.bbsrc.ac.uk), part-funded by the Scottish Beekeeping Association (https://www.scottishbeekeepers.org.uk/) and the Animal Health - Disease Prevention, Scottish Government awarded to ASB CRC. This project received funding from the European Union’s Seventh Framework Programme for research, technological development and demonstration under grant agreement no 613960 (SMARTBEES) (http://www.smartbees-fp7.eu/) awarded to ASB. The funders had no role in study design, data collection and analysis decision to publish, or preparation of the manuscript. Acknowledgments The authors wish to thank Mr W. Thrale, Mr Z. Blackmore, Mr J. Quinlan, and Mr J. Palombo for sample collection from the South East of England and Margie Ramsey for Beinn Eighe National Nature Reserve sample collection.Peer reviewedPublisher PD
Staying in the science stream: patterns of participation in A-level science subjects in the UK.
This paper describes patterns of participation and attainment in A-level physics, chemistry and biology from 1961 to 2009. The A-level has long been seen as an important gateway qualification for higher level study, particularly in the sciences. This long term overview examines how recruitment to these three subjects has changed in the context of numerous policies and initiatives that seek to retain more young people in the sciences. The results show that recruitment to the pure sciences has stagnated, general trends have hardly varied and the track record of government policy in influencing change is not strong. There is no evidence for increasing achievement gaps between the sexes at A-level and even national policy requiring that all young people study science up to the age of 16 appears to have had little impact on recruitment at this leve
Terra incognita—cerebellar contributions to neuropsychiatric and cognitive dysfunction in behavioral variant frontotemporal dementia
Although converging evidence has positioned the human cerebellum as an important relay for intact cognitive and neuropsychiatric processing, changes in this large structure remain mostly overlooked in behavioral variant frontotemporal dementia (bvFTD), a disease which is characterized by cognitive and neuropsychiatric deficits. The present study assessed whether degeneration in specific cerebellar subregions associate with indices of cognition and neuropsychiatric performance in bvFTD. Our results demonstrate a relationship between cognitive and neuropsychiatric decline across various domains of memory, language, emotion, executive, visuospatial function, and motivation and the degree of gray matter degeneration in cerebellar lobules V–VII. Most notably, bilateral cerebellar lobule VII and the posterior vermis emerged as distinct for memory processes, the right cerebellar hemisphere underpinned emotion, and the posterior vermis was highlighted in language dysfunction in bvFTD. Based on cortico-cerebellar connectivity maps, these findings in the cerebellum are consistent with the neural connections with the cortices involved in these domains in patients with bvFTD. Overall, the present study underscores the significance of cortical-cerebellar networks associated with cognition and neuropsychiatric dysfunction in bvFTD
Hybrid Local-Order Mechanism for Inversion Symmetry Breaking
Using classical Monte Carlo simulations, we study a simple statistical
mechanical model of relevance to the emergence of polarisation from local
displacements on the square and cubic lattices. Our model contains two key
ingredients: a Kitaev-like orientation-dependent interaction between nearest
neighbours, and a steric term that acts between next-nearest neighbours. Taken
by themselves, each of these two ingredients is incapable of driving long-range
symmetry breaking, despite the presence of a broad feature in the corresponding
heat capacity functions. Instead each component results in a "hidden"
transition on cooling to a manifold of degenerate states, the two manifolds are
different in the sense that they reflect distinct types of local order.
Remarkably, their intersection---\emph{i.e.} the ground state when both
interaction terms are included in the Hamiltonian---supports a spontaneous
polarisation. In this way, our study demonstrates how local ordering mechanisms
might be combined to break global inversion symmetry in a manner conceptually
similar to that operating in the "hybrid" improper ferroelectrics. We discuss
the relevance of our analysis to the emergence of spontaneous polarisation in
well-studied ferroelectrics such as BaTiO and KNbO.Comment: 8 pages, 8 figure
Beam Based Alignment of Interaction Region Magnets
In conventional beam based alignment (BBA) procedures, the relative alignment
of a quadrupole to a nearby beam position monitor is determined by finding a
beam position in the quadrupole at which the closed orbit does not change when
the quadrupole field is varied. The final focus magnets of the interaction
regions (IR) of circular colliders often have some specialized properties that
make it difficult to perform conventional beam based alignment procedures. At
the HERA interaction points, for example, these properties are: (a) The
quadrupoles are quite strong and long. Therefore a thin lens approximation is
quite imprecise. (b) The effects of angular magnet offsets become significant.
(c) The possibilities to steer the beam are limited as long as the alignment is
not within specifications. (d) The beam orbit has design offsets and design
angles with respect to the axis of the low-beta quadrupoles. (e) Often
quadrupoles do not have a beam position monitor in their vicinity. Here we
present a beam based alignment procedure that determines the relative offset of
the closed orbit from a quadrupole center without requiring large orbit changes
or monitors next to the quadrupole. Taking into account the alignment angle
allows us to reduce the sensitivity to optical errors by one to two orders of
magnitude. We also show how the BBA measurements of all IR quadrupoles can be
used to determine the global position of the magnets. The sensitivity to errors
of this method is evaluated and its applicability to HERA is shown
Sds22 regulates aurora B activity and microtubule-kinetochore interactions at mitosis
Sds22 defines protein phosphatase 1 location and function at kinetochores and subsequent activity of aurora B in mitosis
AMPK Regulation of Mouse Oocyte Meiotic Resumption in Vitro
We have previously shown that the adenosine analog 5-aminoimidazole-4-carboxamide-1-β-d-ribofuranoside (AICAR), an activator of AMP-activated protein kinase (AMPK), stimulates an increase in AMPK activity and induces meiotic resumption in mouse oocytes [Downs, S.M., Hudson, E.R., Hardie, D.G., 2002. A potential role for AMP-activated protein kinase in meiotic induction in mouse oocytes. Dev. Biol, 245, 200–212]. The present study was carried out to better define a causative role for AMPK in oocyte meiotic maturation. When microinjected with a constitutively active AMPK, about 20% of mouse oocytes maintained in meiotic arrest with dibutyryl cAMP (dbcAMP) were stimulated to undergo germinal vesicle breakdown (GVB), while there was no effect of catalytically dead kinase. Western blot analysis revealed that germinal vesicle (GV)-stage oocytes cultured in dbcAMP-containing medium plus AICAR possessed elevated levels of active AMPK, and this was confirmed by AMPK assays using a peptide substrate of AMPK to directly measure AMPK activity. AICAR-induced meiotic resumption and AMPK activation were blocked by compound C or adenine 9-beta-d-arabinofuranoside (araA, a precursor of araATP), both inhibitors of AMPK. Compound C failed to suppress adenosine uptake and phosphorylation, indicating that it did not block AICAR action by preventing its metabolism to the AMP analog, ZMP. 2′-Deoxycoformycin (DCF), a potent adenosine deaminase inhibitor, reversed the inhibitory effect of adenosine on oocyte maturation by modulating intracellular AMP levels and activating AMPK. Rosiglitazone, an anti-diabetic agent, stimulated AMPK activation in oocytes and triggered meiotic resumption. In spontaneously maturing oocytes, GVB was preceded by AMPK activation and blocked by compound C. Collectively, these results support the proposition that active AMPK within mouse oocytes provides a potent meiosis-inducing signal in vitro
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