7 research outputs found
Predictive value of neutrophil/lymphocyte ratio in renal prognosis of patients with granulomatosis with polyangiitis.
Granulomatosis with polyangiitis (GPA) is a rare necrotizing vasculitis, which usually involves the upper and lower respiratory systems and kidneys and often have a relapsing course. Neutrophil/lymphocyte ratio (NLR) has been shown to be a useful marker predicting not only progressive disease, but also mortality in various inflammatory diseases. We aimed to investigate the roles of NLR in predicting the extend of clinical involvement and prognosis of patients with GPA
Association between anticholinergic drug burden with sarcopenia, anthropometric measurements, and comprehensive geriatric assessment parameters in older adults
Background: Older patients use multiple drugs due to their comorbidities and most of these drugs have anticholinergic drug burden (ADB). We aimed to investigate the association between ADB and sarcopenia, anthropometric measurements, and comprehensive geriatric assessment (CGA) parameters in older adults
Serum defensin levels in patients with systemic sclerosis
Background Systemic sclerosis (SSc) is an autoimmune disease
characterized by fibrosis of skin and lung as well as involvement of
kidney, gastrointestinal system and heart. Aetiology and exact mechanism
of disease is poorly understood. The association between antimicrobial
peptides (AMPs) and other diseases such as idiopathic pulmonary
fibrosis, diffuse panbronchiolitis, pulmoner alveolar proteinosis and
psoriasis have been reported. A small number of studies have examined
the role of AMPs on autoimmune diseases which has not been studied in
scleroderma yet. We aimed to investigate AMP serum levels and their
association with disease characteristics of SSc. Methods Forty-two
patients (40 female, mean age 42 years) and 38 healthy subjects (32
female, mean age 38 years) were enrolled. For SSc patients, the
following data were recorded: disease subset (limited/diffuse),
autoantibodies (antinuclear, anti-centromere (ACA), and anti-SCL-70),
blood tests, erythrocyte sedimentation rate (ESR), and C-reactive
protein (CRP), modified Rodnan skin score, presence and history of
digital ulcers, kidney, gastrointestinal disease and lung involvement
assessed by computed tomography and pulmonary function tests.
Association between serum AMPs and disease characteristics were
analysed. Results Twenty-nine of the patients had diffuse (69\%) and 13
of the patients had limited (31\%) systemic sclerosis. Average disease
duration was 5.5 years. Pulmonary involvement was detected in 20
patients (47.6\%). Serum concentration of alpha defensin was higher than
healthy subjects (563 +/- 415 vs 377 +/- 269 ng/mL, p = 0.02). However,
no difference was observed for beta-1 and beta-2 defensins in SSc
patients and healthy controls. In sub-group analysis patients with
interstitial lung disease had higher levels of alpha defensin than those
without lung involvement (684 +/- 473 vs 430 +/- 299 ng/ml, p = 0.04).
There was also correlation between alfa defensin serum concentrations
and CRP (r = 0.34). Conclusions Alpha defensin levels are increased in
scleroderma patients and correlated with lung involvement indicating a
role in the pathogenesis of disease
Association of FGF-19 and FGF-21 levels with primary sarcopenia
Aim Serum fibroblast growth factor (FGF)-19 and FGF-21 levels have been reported to be associated with muscle hemostasis. This study aims to explore the relationship between the levels of these markers and sarcopenia. Methods In our single-center, cross-sectional study, patients over 65 years old presenting to the geriatric outpatient clinic were included. Patients with secondary sarcopenia were excluded. The Strength-Assistance with walking-Rising from a chair-Climbing stairs and Falls (SARC-F) questionnaire was applied to all patients. Sarcopenia was determined by handgrip strength (HGS), bioelectrical impedance analysis and 6-m walk test. Serum samples were stored at -80 degrees C until measurement. The ELISA method was used to assess FGF-19 and FGF-21 levels. Results In total, 88 patients (54 women) were included. There were 43 patients in the sarcopenia group and 45 patients without sarcopenia in the control group. In those with sarcopenia, FGF-19 was lower (P = 0.04) and FGF-21 was higher (P = 0.021). There was a direct correlation between FGF-19 with SARC-F and HGS (P = 0.04, B = 0.178, P = 0.006, B = 0.447) while FGF-21 was inversely correlated with HGS and positively correlated with 6-m walking time (P = 0.016, B = -0.428, P = 0.004, B = 0.506). Conclusions Our results reveal that low FGF-19 and high FGF-21 may be associated with sarcopenia and this finding could be explained by the impacted muscle strength. Geriatr Gerontol Int center dot center dot; center dot center dot: center dot center dot-center dot center dot Geriatr Gerontol Int 2021; center dot center dot: center dot center dot-center dot center dot
The relationship between primary sarcopenia and SARC-F, serum MMP9, TIMP1 levels, and MMP9/TIMP1 ratio in the geriatric patients
Purpose The purpose of this study is to evaluate the relationship between serum MMP9 (Matrix metalloproteinase), TIMP1 (Tissue inhibitor of metalloproteinase) levels and MMP9/TIMP1 ratio and primary sarcopenia in geriatric patients, and compare the diagnostic accuracy of such biomarkers with that of the SARC-F score. Methods A total of 88 patients aged 65 years and older were assessed in the study. Comorbidities and geriatric syndromes were determined and patients with secondary sarcopenia were excluded. EWGSOP2 criteria were used as diagnostic criteria for sarcopenia and SARC-F questionnaire was used to find individuals at risk for sarcopenia. Serum MMP9 and TIMP1 levels were analyzed by ELISA method. Results SARC-F, serum MMP9 and MMP9/TIMP1 ratio were significantly higher in the group with sarcopenia compared to the group without sarcopenia (p = 0.001, p = 0.026 and p = 0.006, respectively). In univariate logistic regression analysis, while SARC-F score and MMP9/TIMP1 ratio were significant, MMP9, TIMP1, age and gender were not. In the multivariate logistic regression analysis of the SARC-F score and the MMP9/TIMP1 ratio, it was determined that both of them were associated with sarcopenia [Odds ratio (OR) 1.447 (95%) confidence interval (CI) 1.170-1.791, p = 0.001; OR 1.127, (95%) CI 1.016-1.249, p = 0.023, respectively]. ROC curve analysis showed that the area under ROC curve (AUC) of SARC-F and MMP9/TIMP1 was 0.703 (p = 0.001, %95 CI 0.594-0.812) and 0.670 (p = 0.006, %95 CI 0.557-0.783), respectively. Conclusion Although this study supports the use of SARC-F questionnaire in daily practice; if SARC-F can't be applicable, the MMP9/TIMP1 ratio could be an alternative choice to the SARC-F
Predictive value of neutrophil/lymphocyte ratio in renal prognosis of patients with granulomatosis with polyangiitis
Introduction: Granulomatosis with polyangiitis (GPA) is a rare
necrotizing vasculitis, which usually involves the upper and lower
respiratory systems and kidneys and often have a relapsing course.
Neutrophil/lymphocyte ratio (NLR) has been shown to be a useful marker
predicting not only progressive disease, but also mortality in various
inflammatory diseases. We aimed to investigate the roles of NLR in
predicting the extend of clinical involvement and prognosis of patients
with GPA.
Materials and methods: Consecutive newly diagnosed GPA patients who had
follow-up for at least 6 months between 2010 and 2016 at Gazi University
Internal Medicine-Rheumatology clinic were retrospectively analyzed.
Results: Fifty-three newly diagnosed GPA patients were studied. NLR was
significantly higher in the GPA group compared with the control group
(4.50 {[}min-max: 0.07-34.81] vs 1.77 {[}min-max: 1.04-2.90],
respectively, p<.001). NLR significantly correlated with ESR and CRP
levels (r = .40 and r = .48, respectively, p<.001 for both).
Discussion: GPA is a vasculitis with a significant morbidity and
mortality (REF). Renal involvement usually presents with crescentric
glomerulonephritis, resulting in significant and permanent loss of renal
functions and end-stage kidney disease. Higher NLR at baseline is
associated with worse renal outcome. Our findings suggest that baseline
NLR could have a predictive value for renal prognosis. We have also
demonstrated a significant correlation between NLR and BVAS activity
scores. Our data suggest that GPA patients with a significantly high NLR
at baseline might need closer follow-up for persistent disease activity
Factors affecting mortality in geriatric patients hospitalized with COVID-19
Background/aim: We aimed to investigate the factors affecting the mortality of patients aged 65 years or older who were hospitalized with the diagnosis of new coronavirus pneumonia (COVID-19)