Urodynamic assessment of short-term effects of pelvic radiotherapy on bladder function in patients with gynecologic cancers

Objectives: To determine the short-term effects of adjuvant or primary curative radiotherapy (RT) on the urinary system in women with gynecologic cancer. Material and methods: This is a prospective, concurrent cohort study including 55 patients with gynecologic cancer who were divided into three groups. Group 1 included 10 patients who were administered adjuvant RT following a radical hysterectomy (RH); Group 2 included 36 patients who were administered adjuvant RT following a type 1 hysterectomy and Group 3 included 9 patients who were administered primary curative RT. Urogynecologic assessments were carried out on patients before and six months after the treatment. Results: Compared to pretreatment, no significant differences were observed in any of the three groups after treatment in terms of incontinence, first urge to urinate, normal urge to urinate, severe urge to urinate and changes in residual urine volumes. There was a significant decrease in maximal vesical pressure after treatment in Group 1 and Group 3. The maxi­mum detrusor pressure decreased significantly in Group 1. The post-treatment decline in bladder capacity in Group 1 and Group 2 was also significant. Conclusions: RH and pelvic RT cause lower urinary system dysfunction. Especially patients who receive primary curative RT and patients who are administered RT after RH, where more pelvic denervation occurs, are at higher risk due to high doses of RT

Fertilite Prezervasyonu Sonuçlarını Öngörmede Antimüllerian Hormon Ve Antral Follikül Sayısının Yeri, Retrospektif Tarama

Amaç Fertilite prezervasyon ( siklusu sonuçlarını tahmin etmek için henüz uygun bir strateji belirlenmemiştir Amacımız, letrozol ve gonadotropinler ( ile gerçekleştirilen kontrollü ovaryan stimülasyona yanıt olarak elde edilecek oosit sayısı tahmininde anti müllerian hormon AMH) ölçümleri ve antral folikül sayılarının ( değerini belirlemekti Gereç ve yöntem Oosit ve/veya embriyo kriyoprezervasyonu için letrozol ve gonadotropinlerin kombine protokolü ile over stimülasyonu uygulanan meme kanserli yüz elli iki kadın hastanın verileri geriye dönük olarak tarandı Siklusun ilk 3 gününde serum AMH ölçümü ve ultrasonografi ile AFC sayımı yapıldı 4 oosit veya 2 embriyo elde edilen hastalar düşük yanıtlı olarak kabul edildi Bulgular Hastaların yaş ortalaması 34 9 4 5 idi AMH, elde edilen oosit sayısı ve dondurularak saklanan embriyo sayısını öngörmede AFC'den daha iyi korelasyon gösterdi (oosit sayısı için r= 0 625 p 0 001 vs r= 0 38 p 0 001 ve embriyo sayısı için r= 0 422 p 0 001 vs r= 0 280 p 0 001 ROC eğrisi analizi sonuçlarında, AMH ve AFC normal yanıtlı hasta grubunda elde edilen oosit sayısını (AMH AUC= 0 896 ve AFC= 0 815 p= 0 223 ve elde edilen embriyo sayısını (AMH için AUC= 0 847 ve AFC= 0 721 p= 0 143 öngörmede benzerdi AMH cut off 1 1 kabul edildiğinde, düşük ovaryen yanıt için pozitif ( ve negatif prediktif değerler ( sırasıyla 100 ve 20 2 idi AFC 6 için PPV ve NPV sırasıyla 90 9 ve 50 idi Sonuç AMH, AFC’ye göre meme kanseri tanısı alan,letrozol ve gonadotropin ile fertilite prezervasyonu uygulanacak hastalarda düşük ovaryen yanıtı öngörmede daha güçlü bir belirteçtir Bu sonuç, kemoterapi öncesi oosit veya embriyo kriyoprezervasyonu uygulanan kadınlara rehberlik etmede faydalı olabili

Comparison of the Effects of Total Laparoscopic Hysterectomy and Total Abdominal Hysterectomy on Sexual Function and Quality of Life

It is known that benign gynecological diseases negatively affect sexual function. For this reason, hysterectomy provides improvement in sexual function as well as symptoms such as bleeding and pain. The effects of abdominal hysterectomy (TAH) and laparoscopic hysterectomy (TLH), which are the two most common types of hysterectomy today, are not clear. In our study, we investigated the effects of TAH and TLH on sexual function and quality of life as well as intraoperative and postoperative results. In 329 TLH and 126 TAH patients, we compared both and between themselves preoperatively and postoperatively by using the standardized and validated female sexual function index (FSFI) and European quality of life five-dimension scale (EQ-5D). In conclusion, we found that both types of hysterectomy were effective in improving sexual function, and we concluded that improvement in the laparoscopy group was statistically higher. Patients who require hysterectomy for benign gynecological reasons should be informed that TLH has a more positive effect on sexual function as well as other advantages, and if the patients’ main complaint is sexual dysfunction, TLH should be preferred compared to TAH

Second primary cancers following borderline ovarian tumors

WOS: 000290536100034PubMed ID: 20628749Several studies have reported an increased risk of second primary cancers subsequent to invasive epithelial ovarian cancer. However, there is no adequate data regarding such risk in borderline ovarian tumors (BOTs). The aim of this study was to evaluate the risk of subsequent second primary cancers among women with BOTs. BOT patients treated in our center between December 1985 and April 2009 were retrospectively screened for developing second primary cancer during follow-up period. There were 96 women diagnosed with BOT. Mean age at the time of diagnosis was 47 +/- A 14.3, ranging from 19 to 79. Eighty-eight (91.6%) patients had stage I disease, two patients (2.1%) had stage II and six (6.2%) had stage III. Twenty-five (26.0%) patients received platinum-based adjuvant chemotherapy. Mean follow-up time was 96.5 +/- A 442 months (range: 9-280 months). There were ten (10.4%) recurrences. Only one patient developed second primary cancer. Second primary cancer observed in this case was basal cell carsinoma of the eyelid, which was diagnosed 2 years after primary disease. There were no patients with common women's cancers such as breast and colorectal cancers. These findings do not suggest increased risk of subsequent cancers in patients with BOT. However, population-based studies are needed for evaluating exact risk of developing second primary malignancies in women with BOTs

Implications of circulating irisin and Fabp4 levels in patients with polycystic ovary syndrome

The aim of the study was to evaluate the fatty acid-binding protein-4 (FABP4) and irisin concentrations in women with polycystic ovary syndrome (PCOS). Forty-nine women with PCOS, diagnosed according to Rotterdam criteria and 39 healthy women matched for body mass index (BMI) and age. Serum irisin and plasma FABP4 concentrations were measured in both groups. The association of irisin and FABP4 concentrations with metabolic parameters were also tested. Women with PCOS had significantly lower mean serum irisin concentrations than control subjects (158.5 +/- 123.3 versus 222.9 +/- 152.2ng/ml, p0.05). FABP4 concentrations were correlated with BMI, waist-hip ratio (WHR) and HOMA-IR (r=0.57, p=0.001; r=0.26, p=0.03; r=0.26, p=0.03, respectively). No associations between irisin and all the others parameters except serum levels of LH were found. Serum irisin concentrations of women with PCOS were lower compared to the controls. Moreover, there were no difference in plasma FABP4 concentrations between women with PCOS and controls