Young children's referent selection is guided by novelty for both words and actions

Young children are biased to select novel, name-unknown objects as referents of novel labels (e.g., Markman, 1990) and similarly favour novel, action-unknown objects as referents of novel actions (Riggs, Mather, Hyde & Simpson, 2015). What process underlies these common behaviors? In the case of word learning, children may be driven by a novelty bias favouring novel objects as referents (Horst, Samuelson, Kucker & McMurray, 2011). Our study investigates this bias further by investigating whether novelty also affects children’s selection of novel objects when a new action is given. In a pre-exposure session, 40, three- and four-year-olds were shown eight novel objects for one minute. In subsequent referent selection trials children were shown two pre-exposed and one super-novel object and heard either a novel name or saw a novel action. The super-novel object was selected significantly more that the pre-exposed objects on both word and action trials. Our data add to the growing literature suggesting that an endogenous attentional bias to novelty plays a role in children’s referent selection and demonstrates further parallels between word and action learning

Get your facts right : preschoolers systematically extend both object names and category-relevant facts

There is an ongoing debate over the extent to which language development shares common processing mechanisms with other domains of learning. It is well-established that toddlers will systematically extend object labels to similarly-shaped category exemplars (e.g., Landau, Smith, & Jones, 1988; Markman & Hutchinson, 1984). However, previous research is inconclusive as to whether young children will similarly extend factual information about an object to other category members. We explicitly contrast facts varying in category relevance, and test for extension using two different tasks. Three- to four-year-olds (N = 61) were provided with one of three types of information about a single novel object: a category-relevant fact (‘it’s from a place called Modi’), a category-irrelevant fact (‘my uncle gave it to me’), or an object label (‘it’s called a Modi’). At test, children provided with the object name or category-relevant fact were significantly more likely to display systematic category extension than children who learnt the category-irrelevant fact. Our findings contribute to a growing body of evidence that the mechanisms responsible for word learning may be domain-general in nature

THE ART SONG OF SOUTH AMERICA: AN EXPLORATION THROUGH PERFORMANCE

The repertoire included in this dissertation was presented over the course of three recitals, The Songs of Argentina, The Songs of Brazil, Chile and Venezuela, and The Songs of Perú and Colombia. Each recital was supplemented by written program notes and English translations of the Spanish, Portuguese and Quechua texts. The selections presented in this study was chosen in an effort to pair the works of internationally renowned composers like Argentine composers Alberto Ginastera and Carlos Guastavino, and Brazilian composer Heitor Villa-Lobos, with those of lesser-known composers, including Venezuelan composer Juan Bautista Plaza, Peruvian composers Edgar Valcárcel, Theodoro Valcárcel, and Rosa Mercedes Ayarza de Morales, and Colombian composer Jaime Léon. Each composer represents a milestone in the development of art song composition in South America. All three recitals were recorded and are available on compact discs in the Digital Repository at the University of Maryland (DRUM). This dissertation was completed in May, 2011

Why would a special FM process exist in adults, when it does not appear to exist in children?

Cooper Greve, and Henson (this issue)  caution restraint before accepting that a fast mapping (FM) process exists in adults. We welcome this, but would also add that the original rationale for studying FM in adults is not currently supported by developmental research. Despite the claims of several adult FM researchers, there is little evidence from developmental word learning research for a special hippocampus-independent FM process critical for children’s word learning

Genetic Diet Analysis of Coyote Scat from Populations in Long Beach

Interactions between humans and local wildlife are inherent to urbanization and have created a demand for wildlife/human management solutions. Coyotes (Canislatrans) are prominent in urban ecosystems and can cause a variety of residential threats. The aim of this study is to monitor coyote distribution and activity in Long Beach, CA to better understand urban predatory behavior and develop local wildlife management techniques. One method for better understanding urban coyotes is through scat analysis, which provides insight into the specific animal species that comprise their diet. This study focuses on prey species identification using DNA isolated from coyote scat samples. DNA was isolated using a modified Chelexmethod, in which scat material was suspended in a higher volume and lower percentage Chelexsolution than the standard method. A 1,000 bpportion of the mitochondrial genome, which contains part of the cytochromebgene and D-loop region, was amplified using PCR. The PCR primers flanked the cytochromeb/D-loop region at sequences that are conserved in nearly all mammals (Foranet al. 1997). Since the amplified region is variable between species, restriction enzymes digest the region into different sized fragments. These fragments were visualized using gel electrophoresis and the banding pattern was read to determine species composition. The amplified DNA was digested using the BfaIrestriction enzyme. Determining dietary information on coyotes allows us to take effective steps towards managing wildlife and educating Long Beach residents on the predators that share their neighborhoods.https://digitalcommons.lmu.edu/cures_posters/1032/thumbnail.jp

Spontaneous Isomerization of Long-Lived Proteins Provides a Molecular Mechanism for the Lysosomal Failure Observed in Alzheimer's Disease.

Proteinaceous aggregation is a well-known observable in Alzheimer's disease (AD), but failure and storage of lysosomal bodies within neurons is equally ubiquitous and actually precedes bulk accumulation of extracellular amyloid plaque. In fact, AD shares many similarities with certain lysosomal storage disorders though establishing a biochemical connection has proven difficult. Herein, we demonstrate that isomerization and epimerization, which are spontaneous chemical modifications that occur in long-lived proteins, prevent digestion by the proteases in the lysosome (namely, the cathepsins). For example, isomerization of aspartic acid into l-isoAsp prevents digestion of the N-terminal portion of Aβ by cathepsin L, one of the most aggressive lysosomal proteases. Similar results were obtained after examination of various target peptides with a full series of cathepsins, including endo-, amino-, and carboxy-peptidases. In all cases peptide fragments too long for transporter recognition or release from the lysosome persisted after treatment, providing a mechanism for eventual lysosomal storage and bridging the gap between AD and lysosomal storage disorders. Additional experiments with microglial cells confirmed that isomerization disrupts proteolysis in active lysosomes. These results are easily rationalized in terms of protease active sites, which are engineered to precisely orient the peptide backbone and cannot accommodate the backbone shift caused by isoaspartic acid or side chain dislocation resulting from epimerization. Although Aβ is known to be isomerized and epimerized in plaques present in AD brains, we further establish that the rates of modification for aspartic acid in positions 1 and 7 are fast and could accrue prior to plaque formation. Spontaneous chemistry can therefore provide modified substrates capable of inducing gradual lysosomal failure, which may play an important role in the cascade of events leading to the disrupted proteostasis, amyloid formation, and tauopathies associated with AD

Randomized pilot trial of the “Mom Power” trauma- and attachment-informed multi-family group intervention in treating and preventing postpartum symptoms of depression among a health disparity sample

IntroductionPerinatal depression, a common complication related to childbearing, impacts mothers, children, and families. Efficacious interventions reduce perinatal depression symptoms; effort is needed to prevent the onset of perinatal depression. To determine feasibility and preliminary efficacy in reducing perinatal depression, we conducted a community-based, randomized parallel open pilot trial of Mom Power, a group-based intervention to improve mental health and parenting in mothers with young children.MethodsMom Power consists of 10 group sessions, focused on parenting, child development and self-care and three individual sessions, to build rapport and provide personalized referrals. Control group participants received psychoeducational mailings. Computer-based urn randomization assigned mothers with experiences of interpersonal violence, depression, or other traumatic experiences to Mom Power (68) or control (54).ResultsAt 3-months post-treatment, the 31 retained women assigned to Mom Power were half as likely to meet criteria for probable depression (26%) as the 22 women retained in the control group (55%), with treatment predicting lower incidence of probable depression (OR = 0.13, p = 0.015). Moreover, among the 23 women who did not meet criteria for depression diagnosis at baseline, no women in the treatment group developed depression (n = 0, 0%) compared to control group women (n = 3, 30%). Logistic regression controlling for selective attrition confirmed the treatment effect on preventing new onset of depression (OR = 0.029, p = 0.012).ConclusionThese findings support the use of Mom Power for both treatment and prevention of perinatal depression.Clinical trial registrationhttps://classic.clinicaltrials.gov/ct2/show/NCT01554215, NCT01554215

Significance of Pelvic Fluid Observed during Ovarian Cancer Screening with Transvaginal Sonogram

The primary objective was to examine the role of pelvic fluid observed during transvaginal ultrasonography (TVS) in identifying ovarian malignancy. A single-institution, observational study was conducted within the University of Kentucky Ovarian Cancer Screening trial from January 1987 to September 2019. We analyzed true-positive (TP), false-positive (FP), true-negative (TN), and false-negative (FN) groups for the presence of pelvic fluid during screening encounters. Measured outcomes were the presence and duration of fluid over successive screening encounters. Of the 48,925 women surveyed, 2001 (4.1%) had pelvic fluid present during a TVS exam. The odds ratio (OR) of detecting fluid in the comparison group (TN screen; OR = 1) significantly differed from that of the FP cases (benign pathology; OR: 13.4; 95% confidence interval (CI): 9.1–19.8), the TP cases with a low malignant potential (LMP; OR: 28; 95% CI: 26.5–29.5), TP ovarian cancer cases (OR: 50.4; 95% CI: 27.2–93.2), and FN ovarian cancer cases (OR: 59.3; 95% CI: 19.7–178.1). The mean duration that pelvic fluid was present for women with TN screens was 2.2 ± 0.05 encounters, lasting 38.7 ± 1.3 months. In an asymptomatic screening population, free fluid identified in TVS exams was more associated with ovarian malignancy than in the control group or benign ovarian tumors. While pelvic free fluid may not solely discriminate malignancy from non-malignancy, it appears to be clinically relevant and warrants thoughtful consideration