Distinguishing different styles of transpressional deformation at an obliquely convergent plate margin, Fiordland, New Zealand

Fiordland, New Zealand provides one of the best-known and deepest (to 65 km) exposures of an Early Cretaceous magmatic arc root known to geologists. These exposures allow for us to study tectonic deformational processes at varying crustal depths, including the role of pre-existing structures on later reactivation. The well-preserved Grebe shear zone (GSZ) marks the boundary between major basement terranes in southern Fiordland and has undergone multiple episodes of deformation during the Cretaceous and Cenozoic time periods. The primary focus of this study is to recognize and characterize the differing phases of deformation that occurred along this shear zone. To investigate these phases, we have conducted structural, finite strain, fault-slip, and kinematic analysis, on structural measurements and samples taken from Fiordland. We use these methods in concert to identify and differentiate the deformational styles. In southern Fiordland, the GSZ is characterized by a narrow zone of protomylonitic-mylonitic fabric within amphibolite retrogressed to greenschist facies rock. Finite strain analysis on feldspar aggregates from samples in and around the GSZ produced primarily oblate ellipsoids, indicative of shortening across the shear zone. Asymmetrical shear sense indicators present in thin sections oriented parallel, perpendicular, and oblique to lineations also suggest a component of sinistral obliquity in shear zone fabrics. This coupled with a deflection of foliations in surrounding rock towards parallelism with the shear zone boundary is consistent with transpressional deformation. This deformation is localized to a zone of ductile deformation where components of sinistral strike-slip and shortening are accommodated in close proximity to the shear zone (non-partitioned). This deformational event is associated with the formation of the shear zone and is overprinted by a separate transpressional event that took place during the Cenozoic. Fault-slip analysis showed that this reactivation event is accommodated in primarily brittle faults in where one set accommodates mostly or purely strike-slip motion, and another that accommodates mostly or purely reverse motion (partitioned). This contrasting style of transpression implies that the Cretaceous ductile shear zone influenced the behavior of strain during Cenozoic reactivation

Segmental and Intersegmental Coordination Characteristics of a Cognitive Movement Control Test: Quantifying Loss of Movement Choices

Cognitive movement control tests are hypothesized to reveal reduced coordination variability, a feature of motor behaviour linked to clinical presentations. Exploration of this proposition via kinematic analysis of test pass and fail conditions is yet to be conducted. Kinematics (3D) were collected as 28 participants were qualitatively rated during nine trials of a cognitive movement control test. Ten female and two male participants passing the test were matched to twelve participants who failed (three males, nine females). Sagittal plane pelvis and knee angles were determined. Peak pelvic deviation and knee flexion maxima/minima were compared between groups. Classification tree analysis explored relationships between test failure and pelvis–knee intersegmental coordination strategy classifications derived from novel and traditional vector coding techniques. Coordination variability waveforms were assessed via SPM. Age, BMI, and knee flexion values did not differ between the groups (p > 0.05); however, participants rated as failing the test displayed greater pelvic deviation (p < 0.05). Classification tree analysis revealed a greater use of pelvic dominant intersegmental coordination strategies from both vector coding techniques (p < 0.001) by fail-group participants. The fail-group also displayed lower coordination variability for novel (p < 0.05), but not traditional (p > 0.05) vector coding technique waveforms, supporting the premise that the testing protocol may act as a qualitative approach to inform on features of motor behavior linked to clinical presentations

Exome sequencing identifies nonsegregating nonsense ATM and PALB2 variants in familial pancreatic cancer.

We sequenced 11 germline exomes from five families with familial pancreatic cancer (FPC). One proband had a germline nonsense variant in ATM with somatic loss of the variant allele. Another proband had a nonsense variant in PALB2 with somatic loss of the variant allele. Both variants were absent in a relative with FPC. These findings question the causal mechanisms of ATM and PALB2 in these families and highlight challenges in identifying the causes of familial cancer syndromes using exome sequencing

Bisphenol A and Phthalates: Public Knowledge and Risk Perception

Introduction: Bisphenol A (BPA) and phthalates are chemicals used in the production of many plastics, including food containers, water bottles, and medical intravenous tubing. These chemicals can leach from the plastic, especially when heated, and are found in varying concentrations in the human body. There is concern about the widespread exposure to BPA and phthalates since studies indicate they may cause adverse health effects, particularly related to endocrine development and regulation in young children.https://scholarworks.uvm.edu/comphp_gallery/1041/thumbnail.jp

Clock-Controlled and Cold-Induced CYCLING DOF FACTOR6 Alters Growth and Development in Arabidopsis

The circadian clock represents a critical regulatory network, which allows plants to anticipate environmental changes as inputs and promote plant survival by regulating various physiological outputs. Here, we examine the function of the clock-regulated transcription factor, CYCLING DOF FACTOR 6 (CDF6), during cold stress in Arabidopsis thaliana. We found that the clock gates CDF6 transcript accumulation in the vasculature during cold stress. CDF6 mis-expression results in an altered flowering phenotype during both ambient and cold stress. A genome-wide transcriptome analysis links CDF6 to genes associated with flowering and seed germination during cold and ambient temperatures, respectively. Analysis of key floral regulators indicates that CDF6 alters flowering during cold stress by repressing photoperiodic flowering components, FLOWERING LOCUS T (FT), CONSTANS (CO), and BROTHER OF FT (BFT). Gene ontology enrichment further suggests that CDF6 regulates circadian and developmental-associated genes. These results provide insights into how the clock-controlled CDF6 modulates plant development during moderate cold stress

Student Composers Concert

Kennesaw State University School of Music presents the 2013 Student Composers Concert featuring Premieres of Newly Composed Works.https://digitalcommons.kennesaw.edu/musicprograms/1348/thumbnail.jp

Forest biomass diversion in the Sierra Nevada: Energy, economics and emissions

As an alternative to open pile burning, use of forest wastes from fuel hazard reduction projects at Blodgett Forest Research Station for electricity production was shown to produce energy and emission benefits: energy (diesel fuel) expended for processing and transport was 2.5% of the biomass fuel (energy equivalent); based on measurements from a large pile burn, air emissions reductions were 98%-99% for PM2.5, CO (carbon monoxide), NMOC (nonmethane organic compounds), CH4 (methane) and BC (black carbon), and 20% for NOx and CO2-equivalent greenhouse gases. Due to transport challenges and delays, delivered cost was $70 per bone dry ton (BDT) - comprised of collection and processing ($34/BDT) and transport ($36/BDT) for 79 miles one way - which exceeded the biomass plant gate price of$45/BDT. Under typical conditions, the break-even haul distance would be approximately 30 miles one way, with a collection and processing cost of $30/BDT and a transport cost of$16/BDT. Revenue generated from monetization of the reductions in air emissions has the potential to make forest fuel reduction projects more economically viable

High-Frequency Oscillatory Ventilation Use and Severe Pediatric ARDS in the Pediatric Hematopoietic Cell Transplant Recipient

INTRODUCTION: The effectiveness of high-frequency oscillatory ventilation (HFOV) in the pediatric hematopoietic cell transplant patient has not been established. We sought to identify current practice patterns of HFOV, investigate parameters during HFOV and their association with mortality, and compare the use of HFOV to conventional mechanical ventilation in severe pediatric ARDS. METHODS: This is a retrospective analysis of a multi-center database of pediatric and young adult allogeneic hematopoietic cell transplant subjects requiring invasive mechanical ventilation for critical illness from 2009 through 2014. Twelve United States pediatric centers contributed data. Continuous variables were compared using a Wilcoxon rank-sum test or a Kruskal-Wallis analysis. For categorical variables, univariate analysis with logistic regression was performed. RESULTS: The database contains 222 patients, of which 85 subjects were managed with HFOV. Of this HFOV cohort, the overall pediatric ICU survival was 23.5% (n = 20). HFOV survivors were transitioned to HFOV at a lower oxygenation index than nonsurvivors (25.6, interquartile range 21.1-36.8, vs 37.2, interquartile range 26.5-52.2, P = .046). Survivors were transitioned to HFOV earlier in the course of mechanical ventilation, (day 0 vs day 2, P = .002). No subject survived who was transitioned to HFOV after 1 week of invasive mechanical ventilation. We compared subjects with severe pediatric ARDS treated only with conventional mechanical ventilation versus early HFOV (within 2 d of invasive mechanical ventilation) versus late HFOV. There was a trend toward difference in survival (conventional mechanical ventilation 24%, early HFOV 30%, and late HFOV 9%, P = .08). CONCLUSIONS: In this large database of pediatric allogeneic hematopoietic cell transplant subjects who had acute respiratory failure requiring invasive mechanical ventilation for critical illness with severe pediatric ARDS, early use of HFOV was associated with improved survival compared to late implementation of HFOV, and the subjects had outcomes similar to those treated only with conventional mechanical ventilation

FORUM:Remote testing for psychological and physiological acoustics

Acoustics research involving human participants typically takes place in specialized laboratory settings. Listening studies, for example, may present controlled sounds using calibrated transducers in sound-attenuating or anechoic chambers. In contrast, remote testing takes place outside of the laboratory in everyday settings (e.g., participants' homes). Remote testing could provide greater access to participants, larger sample sizes, and opportunities to characterize performance in typical listening environments at the cost of reduced control of environmental conditions, less precise calibration, and inconsistency in attentional state and/or response behaviors from relatively smaller sample sizes and unintuitive experimental tasks. The Acoustical Society of America Technical Committee on Psychological and Physiological Acoustics launched the Task Force on Remote Testing (https://tcppasa.org/remotetesting/) in May 2020 with goals of surveying approaches and platforms available to support remote testing and identifying challenges and considerations for prospective investigators. The results of this task force survey were made available online in the form of a set of Wiki pages and summarized in this report. This report outlines the state-of-the-art of remote testing in auditory-related research as of August 2021, which is based on the Wiki and a literature search of papers published in this area since 2020, and provides three case studies to demonstrate feasibility during practice