45 research outputs found

    Alloreactive memory T cells induce chronic graft-versus-host disease

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    Incidence, spatial pattern and temporal progress of Fusarium wilt of bananas

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    The effective management of Fusarium wilt of bananas (FWB) depends on the knowledge of the disease dynamics in time and space. The objectives of this work were: to estimate disease intensity and impact, and to investigate the spatial and temporal dynamics of FWB. Fields planted with Silk (n = 10), Pome (n = 17), or Cavendish (n = 3) banana subgroups were surveyed in Brazil, totaling 95 ha. In each field, all plants were visually assessed, and diseased plants were georeferenced. The incidence of FWB and the impact of the disease on the yield on a regional scale were estimated. Spatial patterns were analyzed using quadrat- and distance-based methods. FWB incidence ranged from 0.09% to 41.42%, being higher in Silk fields (median = 14.26%). Impacts of epidemics on yield ranged from 18.4 to 8192.5 kg ha−1 year−1, with an average of 1856.7 kg ha−1 year−1. The higher economic impact of the disease was observed on Silk cultivar with an average loss of USD 1974.2 ha−1 year−1. Overall, estimated losses increased on average by USD 109.8 ha−1 year−1 at each 1% of incidence. Aggregation of FWB was detected by all analytical methods in 13 fields (1 of Cavendish, 11 of Pome, and 1 of Silk). In the other 17 fields, at least one analytical method did not reject the null hypothesis of randomness. One field (5 ha), composed of six plots, was selected for spatial and temporal studies during two years with bi-monthly assessments. A sigmoidal curve represented the FWB progress and the Gompertz model best-fitted disease progress. The level of aggregation varied over time, and evidence of secondary infection to neighboring and distant plants was detected. FWB is a widespread problem in Brazil and yield losses can be of high magnitude. Epidemiology-based management strategies can now be better established

    Impacto do programa bolsa família sobre a frequência escolar: o caso da agricultura familiar no Nordeste do Brasil.

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    O objetivo deste trabalho é avaliar o impacto do programa de transferência de renda condicionada Bolsa Família sobre a frequência escolar de crianças e adolescentes de cinco a 14 anos na agricultura familiar dos estados de Pernambuco, Ceará, Sergipe e Paraíba. Nessa investigação, o trabalho faz uso de dados primários (pesquisa de campo) e dados secundários (PNAD, 2005) para obter estimativas de propensity score. Os resultados indicam que, de forma geral, o programa eleva a frequência escolar das referidas crianças no intervalo de 5,4 a 5,9 pontos percentuais. Contudo, há importantes diferenças quando se considera meninas e meninos separadamente, sendo o programa eficaz no primeiro caso e ineficaz no segundo. Ou seja, apesar da avaliação positiva para as meninas, não parece haver efeito do programa sobre a frequência escolar dos meninos, o que pode estar associado a diferenças de gênero nos custos de oportunidades do investimento em capital humano no meio rural

    Evolving market effciency with an application to some Bulgarian shares

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    SIGLEAvailable from British Library Document Supply Centre-DSC:7742.6443(96/18) / BLDSC - British Library Document Supply CentreGBUnited Kingdo

    Characterizing opioid agonist therapy uptake and factors associated with treatment retention among people with HIV in British Columbia, Canada

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    Accidental overdoses are now the leading cause of death among people with HIV (PWH) in British Columbia (BC). We examined the utilization and retention of opioid agonist therapy (OAT).Adult PWH (≥19 years) with ≥ 1 OAT dispensation in BC between 2008 and 2020 were included (n = 1,515). OAT treatment episodes were formed based on specific criteria for slow-release oral morphine (SROM), methadone, injectable OAT (iOAT), and buprenorphine/naloxone. Retention in treatment was defined as any episode lasting ≥ 12 months. Logistic regression with generalized estimating equations modeled retention-associated factors.There was a 56.6% decline in OAT retention over time. Buprenorphine treatment exhibited significantly lower odds of retention (OR: 0.58; 95% CI: 0.36–0.92) compared to methadone. Conversely, no significant change in retention odds was observed for SROM (0.72; 0.33–1.54) and iOAT (0.81; 0.31–2.12). Factors associated with increased odds of retention included a 10-year increase in age (1.69; 1.46–1.95), previous retention history (1.96; 1.40–2.73), achieving OAT therapeutic dose (8.22; 6.67–10.14), and suppressed HIV viral load (1.35; 1.10–1.67). Individuals with a lifetime HCV diagnosis receiving iOAT were more likely to retain (3.61; 1.20–10.83). Each additional year on OAT during the study period was associated with a 4% increase in the odds of retention.A significant proportion of PWH had a history of OAT prescribing but experienced low retention rates. Retention outcomes were more positive for SROM and iOAT. The association between OAT medication type and retention odds may be particularly influenced by HCV diagnosis. Optimal management of opioid use disorder among PWH, with an emphasis on attaining the therapeutic dose is crucial
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