One-pot three-component synthesis of some new azo-pyrazoline derivatives

The starting material azo-benzyloxy acetophenone (2) has been synthesized in three steps; the direct diazotization of p-aminoacetophenone and its coupling reaction with m-cresol gave azo-acetophenone (1), which was benzylated with p-chlorobenzylchloride to give the starting material (2). The later compound was subjected to the one-pot three-component condensation reaction with substituted benzaldehydes and phenylhydrazine in the presence of sodium hydroxide to afford the target molecule azo-pyrazoline derivatives (3a-e) in high yields and short reaction times. The structures of the synthesized compounds were elucidated by using FT-IR, 1H NMR, 13C NMR and 13C DEPT 135 spectra

Factors associated with perinatal substance use among Ethiopian women: an institutional-based cross-sectional study

Introduction: Substance use during the perinatal period is a significant public health concern, as it can have potential adverse effects on maternal and neonatal health outcomes. Unexpectedly, no previous studies have been conducted to assess the prevalence of substance use during the perinatal period among Ethiopian women. Therefore, this study aimed to determine the magnitude of substance use and its determinant factors during the perinatal period.Method: We conducted a hospital-based descriptive cross-sectional study among a systematically selected sample of 418 women who attended perinatal care between May and July 2022. Data were collected using an interviewer-administered structured questionnaire. Multivariate logistic regression analysis, with a 95% confidence interval and p-values less than 0.05, was employed to identify factors associated with substance use behavior.Result: The prevalence of perinatal substance use was found to be 38.3% (95% CI: 33.5–43.5). Of the women who used substances, 109 (26.1%) reported using chat, 46 (11.0%) reported alcohol consumption, and 5 (1.20%) reported using shisha. Factors significantly associated with substance use behavior during the perinatal period included a history of obstetric complications (AOR = 1.722, 95% CI: 1.022–2.902), the presence of chronic medical conditions (AOR = 3.784, 95% CI: 2.164–6.615), experiencing physical abuse (AOR = 5.323, 95% CI: 2.171–13.050), depression (AOR = 1.963, 95% CI: 1.028–3.749), and experiencing sleep disturbances (AOR = 2.016, 95% CI: 0.975–4.168). Conversely, giving birth to a live baby was found to be a protective factor against substance use behavior (AOR = 0.389, 95% CI: 0.187–0.810).Discussion: This study highlights a high prevalence of substance abuse among women during the perinatal period. In light of these findings, a comprehensive approach is recommended to address perinatal substance use among Ethiopian women. This should include the integration of preventive educational programs into perinatal care

Excessive Daytime Sleepiness and Associated Factors Among Women in Perinatal Period

Background and Objective Excessive daytime sleepiness (EDS) is an important public health issue requiring adequate screening and management to avoid such harmful consequences. The study aimed to assess the prevalence and risk factors of EDS in the perinatal period. Methods Institution-based cross-sectional study was carried out in selected public health institutions of Ethiopia on systematic selected 362 women during perinatal period. We used a validated Epworth daytime sleepiness tool to collect data. Epi-InfoTM 7 and SPSS version 26 were used for data entry and analysis, respectively. Bivariable and multivariable binary logistic regression analyses were conducted to determine the associated factors. Results The prevalence of EDS was 16.6% (95% CI: 12.6–20.7). Excessive pregnancy-related concern (adjusted odds ratio [AOR] = 0.232, 95% CI: 0.087–0.621), having depression symptoms (AOR = 8.045, 95% CI: 3.375–19.174), anxiety symptoms (AOR = 4.905, 95% CI: 2.083– 11.550) and having a chronic medical illness (AOR = 5.441, 95% CI: 2.273–13.021) were the factors associated with EDS. Conclusions The results of the current study suggested that perinatal EDS among women in northern part of Ethiopia is a highly prevalent and associated with excessive pregnancy concern, depression, anxiety, and medical illness

Crystal structures of 4-phenylpiperazin-1-ium 6-chloro-5-ethyl-2,4-dioxopyrimidin-1-ide and 4-phenylpiperazin-1-ium 6-chloro-5-isopropyl-2,4-dioxopyrimidin-1-ide

The title molecular salts, C10H15N2+·C6H6ClN2O2−, (I), and C10H15N2+·C7H8ClN2O2−, (II), consist of 4-phenylpiperazin-1-ium cations with a 6-chloro-5-ethyl-2,4-dioxopyrimidin-1-ide anion in (I) and a 6-chloro-5-isopropyl-2,4-dioxopyrimidin-1-ide anion in (II). Salt (I) crystallizes with two independent cations and anions in the asymmetric unit. In the crystal structures of both salts, the ions are linked via N—H...O and N—H...N hydrogen bonds, forming sheets which are parallel to (100) in (I) and to (001) in (II). In (I), the sheets are linked via C—H...Cl hydrogen bonds, forming a three-dimensional framework

Employing The Vocabulary Of Jordanian Heritage In The Interior Design Of Accommodation Units In Tourist Facilities

The national heritage is considered important pillars of tourism development, Tourism is also considered a mean of spreading mutual cultures between countries, Further, tourism in the Hashemite Kingdom of Jordan represents one of the most important activities that work on development and prosperity. Jordan hosts a number of important tourist archaeological sites,such as the pink city of Petra;Jerash; the Roman amphitheater, these places are considered a destination for all tourists. Tourism facilities are considered one of the components of civilization and a vital element in its constructions, this requires the interior designer to link the surrounding environment with the interior design to maintain its originality and heritage identity Therefore, the interior designer goal is to create a design vision to attract the tourist and push him to interact with the surrounding environment, Moreover, many tourist facilities have appeared in Jordan, but it lacks the local identity in interior design and it are not connected to the surrounding environment,Such facilities also established on architectural models that do not suit the cultural and civilizational richness of Jordan, Therefore This research aims to create a design vision to employ Jordanian heritage in interior design and furniture for tourist facilities to preserve its originality and identity, and creating a distinctive and special character for the interior design stemming from the surrounding environment;as well as supporting the functional, aesthetic and cultural aspects of the design process, Hence the importance of research lies in analyzing the design elements of Jordanian heritage and reviving its design lines to be used in interior design in order to develop aesthetic sense and general taste in the community, which leads to increase the elements of tourist attractions for tourist facilities, The research went on to study and analyze the heritage elements and reduce lines that can be employed in interior design supporting the aesthetic values of the place, this research has reached a design vision to employ Jordanian heritage in interior design in the hotel accommodation room, The researcher also presented a proposal to design a hotel residence room that employed design lines inspired by Jordanian heritage in a reduced style to suit contemporary life and achieve functional and aesthetic aspects in tourist facilities. So, the research leads to a vision of design style for tourist facilities with a heritage identity has been drawn through two main directions:First: studying heritage elements and analyzing its design lines

The magnitude of perinatal depression and associated factors among women in Kutaber woreda public health institution and Boru Meda general hospital, Ethiopia, 2022: a cross-sectional study

BackgroundPerinatal depression, characterized by the presence of depressive symptoms during pregnancy and/or within the first 12 months postpartum, poses a significant global public health concern. It contributes to a multitude of health risks for mothers, their infants, and their families. Understanding of perinatal depression and its associated factors is crucial for effective prevention and intervention strategies. However, there is a lack of comprehensive research on this topic in Ethiopia. Therefore, this study aims to determine the prevalence and factors contributing to perinatal depression among Ethiopian women.MethodsAn institutional-based cross-sectional study was conducted, involving 552 women receiving perinatal services at Kutaber district health institution and Boru Meda General Hospital. Study participants were selected through systematic random sampling techniques. Perinatal depression was assessed using the Depression, Anxiety, and Stress Scale-21 (DASS-21). The associations between various determinants and perinatal depression were examined using binary logistic regression, and factors with a p-value of less than 0.2 were included in the multiple logistic regression analysis. A p-value less than 0.05 was considered statistically significant.ResultsThe prevalence of perinatal depression was found to be 32.2%. The prevalence of perinatal depression was found to be 32.2%. Factors significantly associated with perinatal depression included being a student [adjusted odds ratio (AOR) = 4.364, 95% confidence interval (CI): 1.386, 13.744], experiencing excessive pregnancy-related concerns (AOR = 1.886, 95% CI: 1.176, 3.041), past substance use (AOR = 2.203, 95% CI: 1.149, 4.225), the presence of anxiety symptoms (AOR = 3.671, 95% CI: 2.122, 6.352), experiencing stress symptoms (AOR = 6.397, 95% CI: 3.394–12.055), and daytime sleepiness (AOR = 2.593, 95% CI: 1.558, 4.316).ConclusionThe findings of this study indicate a relatively high prevalence and valuable factors associated with perinatal depression. It highlights the need for a comprehensive approach to perinatal mental health that takes into account not only the biological aspects of pregnancy but also the psychological, social, and lifestyle factors that can impact a person’s mental well-being during this critical period

دور المؤسسات الدينية في خدمة السنة النبوية في عصر الرقمنة دار الإفتاء المصرية نموذجا

تعتبر دار الإفتاء المصرية من المؤسسات الدينية العريقة على مستوى العالم الإسلامي، فهي تحمل تاريخا مشرقا منذ نشأتها في عام 1895م وحتى الآن، والراصد لتاريخ هذه المؤسسة يرى أنها تعمل جاهدة على تقديم المشورة الدينية للمسلمين في مصر، وفي كل جوانب العالم الإسلامي بصورة تتسم في مجملها بالتأصيل الشرعي الرَّصِين. وقد حدث لهذه المؤسسة تطورا ملحوظا على يدي المفتي السابق الأستاذ الدكتور على جمعة، حيث طور من أدائها واستفاد من التكنولوجيا الحديث للوصول إلى شريحة أكبر من الجماهير. ويأتي هذا البحث للوقوف على جهود دار الإفتاء المصرية في خدمة السنة النبوية من خلال موقعها الرسمي بغرض بيان هذا الدور المهم، والذي تبين بعد مطالعة الموقع أن المؤسسة لا تقتصر على الدور الفقهي فقط، بل لها دور ظاهر في ردها على الكثير من الشبهات التي تثار حول السنة من آن لآخر. وكذلك سيقوم الباحث بعرض لتجربتها في المشاركة في خدمة السنة النبوية من خلال الموسوعات الحديثية التي شاركت فيها كموسعة جامع الأحاديث، حيث جمعت فيها الأحاديث التي ذكرها السيوطي والمتقي الهندي والمناوي والنبهاني في كتبهم الحديثية، وصدرت في عام 2005 بالتعاون مع وزارة الأوقاف الكويتية. وهذا بغرض الاستفادة من هذه التجربة النافعة، لعل في ذلك تحفيزًا للمؤسسات الدينية في بلاد العالم الإسلامي لكي تحذو حذوها

Assessment of Retinal Nerve Fiber Layer Thickness Using Optical Coherence Tomography Before and After Ranibizumab Intravitreal Injection in Patients with Diabetic Macular Edema

Background: Anti-Vascular Endothelial Growth Factor (Anti-VEGF) therapy serves to decrease central retinal thickness in eyes affected with diabetic macular edema (DME). The Retinal Nerve Fiber Layer (RNFL) forms the basis of the optic nerve. Objectives: Our study is concerned with studying the effects of Anti-VEGF injections in patients with DME on RNFL thickness. Patients and methods: This was a prospective cohort interventional study conducted at South Valley University Hospital, Ophthalmology department outpatient clinic. It included 50 diabetic patients with diabetic macular edema whose RNFL thickness was measured before the anti-VEGF injections and again after the completion of the three injections treatment course using spectral domain optical coherence tomography (SD-OCT). Results: This study included 50 eyes from 50 patients. 35 (70%) of them were females and 15 (30%) of them were males. 26 patients (52%) had their right eye injected, and 24 patient (48%) had their left eye injected. The superior quadrant of the RNFL showed a mean increase of 1.2 microns (SD = 38.4, 95% Confidence Interval CI = -9.7:12.1, p value = 0.829). The inferior quadrant showed a mean increase of 7.5 microns (SD = 35.6, 95% CI = -2.6:17.6, p value = 0.144). The nasal quadrant showed a mean increase of 8.3 microns (SD = 23, 95% CI = 1.8:14.9, p value = 0.014). The temporal quadrant showed a mean increase of 4.1 microns (SD = 33.2, 95% CI = -5.3:13.6, p value = 0.386). Conclusion: There is no statistically significant correlation between intra-vitreal injections of anti-VEGF and the RNFL thickness

Experimental and theoretical investigations of Erbium complex: DNA/BSA interaction, anticancer and antibacterial studies

To assess the biological potential of an Er complex that contains a 2,2'-bipyridine ligand, various techniques such as multispectral and molecular modeling procedures were utilized to examine its DNA-binding ability, BSA binding affinity, antimicrobial effects, and anticancer properties. By analyzing fluorescent information and employing the vant’ Hoff equation, important parameters such as the innate docking coefficient (Kb), Stern-Volmer coefficient (KSV), and thermodynamic properties including modifications in liberated energy (ΔG°), enthalpy (∆H°), and entropy (∆S°) were determined. The trial findings suggest that the compound can bind to DNA, primarily through groove binding. Additionally, the engagement between the Er compound and the protein BSA was examined using emission spectroscopy technique, revealing a powerful binding affinity between the compound and BSA. The Er complex binds to BSA primarily via hydrogen links and van der Waals forces, as indicated by the adverse values of ΔH° and ∆S°. Through a static quenching process, the complex significantly reduces the intrinsic fluorescence of BSA. Molecular binding calculations and rivalrous binding trials confirm that this compound dock to hydrophobic remains found in site III of BSA. Additionally, the Er complex demonstrates promising results in terms of its anticancer and antimicrobial activities based on screening tests