Verbreitung und Ausbildung Elster-zeitlicher Ablagerungen zwischen Elm und Flechtinger Höhenzug

Im östlichen Niedersachsen und westlichen Sachsen-Anhalt wurden in den letzten Jahrzehnten in zwei großen Untersuchungskampagnen mächtige quartäre Ablagerungen beobachtet und dokumentiert. Die Elster-zeitlichen Anteile dieser Ablagerungen sind Gegenstand dieser Veröffentlichung. Ablagerungen der ältesten Vereisung aus diesem Gebiet wurden schon vor über 100 Jahren beschrieben. Im Helmstedter Braunkohlerevier waren über lange Zeit über mächtigen Vorschütt-Schmelzwassersanden zwei Elster-Grundmoränen aufgeschlossen. Stillwasserbildungen verschiedenster Ausbildung waren Zeugen des periglaziären Geschehens in diesem Raum. Am Ende des Pleniglazials kamen in kleinen Seen limnische Sedimente zur Ablagerung, die Hinweise auf mehrere Spätelster-Interstadiale lieferten. Im Zuge einer sehr umfangreichen ingenieurgeologischen Erkundung im nur wenige Kilometer entfernten Allertal bei Morsleben wurden dort einige Jahre später zahlreiche Kernbohrungen niedergebracht und intensiv geologisch dokumentiert und beprobt. Die erbohrten Ablagerungen ähneln den Elster-zeitlichen Sedimenten aus dem Tagebau Schöningen, sind jedoch durch zahlreiche Subrosionssenken noch mächtiger. Hierdurch lassen sich auch mehrere kleine Oszillationen zu Beginn der Überfahrung durch das Elster-Inlandeis nachweisen. An einer Stelle im Allertal ist zudem relativ sicher eine jüngste dritte Elster-Grundmoräne nachweisbar. Die periglazären Bildungen kamen hier in einem eher fluviatil geprägten Milieu zur Ablagerung, das auch die Erhaltung sicher zuordnenbarer Spätelster-Interstadiale behinderte. Eine Korrelation der beobachteten Ablagerungen mit denen anderer Räume ist bisher nur regional, nicht jedoch überregional möglich.researc

Eine eem- und frühweichselzeitliche Abfolge im Tagebau Schöningen, Landkreis Helmstedt

Im ostniedersächsischen Braunkohlengebiet bei Helmstedt waren von 1985 —1987 im Tagebau Schöningen mächtige eeminter glaziale Bildungen aufgeschlossen. Die mit teils autochthonen, teils allochthonen Kalk-Schluff-Torf-Abfolgen gefüllte, mehrere hundert Meter lange Rinne stellt das ehemalige Bett eines Baches dar, der unweit der heutigen „Mißaue" floß. In dem Lockertravertin waren Holzreste, Früchte, Samen, Molluskenschalen und Moospolster reichlich vertreten. Die pollenanalytischen Untersuchungsergebnisse des Travertins und hangender Löß-Humuszonen spiegeln die für den nordwestdeutschen Raum bekannten Grundzüge der eem- und den Beginn der frühweichselzeitlichen Vegetationsentwicklung wider.researc

Association of candidate pharmacogenetic markers with platinum-induced ototoxicity:PanCareLIFE dataset

Genetic association studies suggest a genetic predisposi- tion for cisplatin-induced ototoxicity. Among other candidate genes, thiopurine methyltransferase ( TPMT ) is considered a critical gene for susceptibility to cisplatin-induced hearing loss in a pharmacogenetic guideline. The PanCareLIFE cross- sectional cohort study evaluated the genetic associations in a large pan-European population and assessed the diagnos- tic accuracy of the genetic markers. 1,112 pediatric cancer survivors who had provided biomaterial for genotyping were screened for participation in the pharmacogenetic association study. 900 participants qualified for inclusion. Based on the assessment of original audiograms, patients were assigned to three phenotype categories: no, minor, and clinically relevant hearing loss. Fourteen variants in eleven candidate genes ( ABCC3, OTOS, TPMT, SLC22A2, NFE2L2, SLC16A5, LRP2, GSTP1, SOD2, WFS1, and ACYP2 ) were genotyped. The genotype and phenotype data represent a resource for conducting meta- analyses to derive a more precise pooled estimate of the ef- fects of genes on the risk of hearing loss due to platinum treatment

Association of candidate pharmacogenetic markers with platinum-induced ototoxicity: PanCareLIFE dataset

Genetic association studies suggest a genetic predisposition for cisplatin-induced ototoxicity. Among other candidate genes, thiopurine methyltransferase (TPMT) is considered a critical gene for susceptibility to cisplatin-induced hearing loss in a pharmacogenetic guideline. The PanCareLIFE cross-sectional cohort study evaluated the genetic associations in a large pan-European population and assessed the diagnostic accuracy of the genetic markers. 1,112 pediatric cancer survivors who had provided biomaterial for genotyping were screened for participation in the pharmacogenetic association study. 900 participants qualified for inclusion. Based on the assessment of original audiograms, patients were assigned to three phenotype categories: no, minor, and clinically relevant hearing loss. Fourteen variants in eleven candidate genes (ABCC3, OTOS, TPMT, SLC22A2, NFE2L2, SLC16A5, LRP2, GSTP1, SOD2, WFS1, and ACYP2) were genotyped. The genotype and phenotype data represent a resource for conducting meta-analyses to derive a more precise pooled estimate of the effects of genes on the risk of hearing loss due to platinum treatment

World ocean review: Mit den Meeren leben 6: Arktis und Antarktis – extrem, klimarelevant, gefährdet

Die sechste Ausgabe des „World Ocean Review“ (WOR) widmet sich der Arktis und Antarktis, diesen zwei extremen und ausgesprochen gegensätzlichen Regionen der Erde. Mit profunden Informationen zur Entstehungs- und Entdeckungsgeschichte bietet der WOR 6 ein tiefes Verständnis der Bedeutung der Pole für das Leben auf unserer Erde. Er zeigt zudem die zu beobachtenden Veränderungen in der Tier-und Pflanzenwelt und analysiert die zum Teil schon dramatischen Folgen, die der Klimawandel in diesen äußerst gefährdeten Regionen bewirkt

Association between diesel exposure at work and prostate cancer

Objectives: The possible etiologic relevance of occupational factors such as cadmium, cutting oils, diesel fuel and fumes, herbicides, polycyclic aromatic hydrocarbons (PAH), polychlorinated biphenyls, soot, tar, mineral oil, and solvents to prostate cancer was studied. Methods: A case-referent study design was used to recruit 192 subjects with histologically confirmed prostate cancer and 210 referents who had prostate cancer histologically excluded either in one of two urologic practices (Hamburg and Frankfurt) or in the urological policlinic of the Frankfurt University. Data were gathered with a self-administered questionnaire and analyzed using logistic regression to control for age, region, and cigarette smoking. A job-exposure matrix was used for assigning exposure. For the calculation of dose-years, the duration of contact with specific substances was weighted by the intensity and probability of exposure according to a job-exposure matrix. Results: The analysis of dose-years yielded a statistically significant association between occupational exposure to diesel fuel or fumes and prostate cancer (odds ratio 3.7, 95% confidence interval 1.4-9.8, for subjects exposed to more than 25 dose-years in a comparison with subjects never exposed). For the other substances, no statistically significant differences in exposure were found between the cases and referents. When only jobs with a high exposure probability were used to classify the participants as exposed, only exposure to PAH was significantly associated with prostate cancer. Conclusion: In keeping with results from other studies, this study provides further evidence that exposure to diesel fuel or fumes - possibly mediated through PAH - may be associated with the development of prostate cancer

Sleep apnea and occupational exposure to solvents

Objectives: The possible effects of exposure to neurotoxic substances such as gasoline, diesel fuel, paint, varnish, and solvents on the pathogenesis of obstructive sleep apnea were examined. Methods: Four hundred and forty-three persons with incident obstructive sleep apnea were recruited within the framework of a case-referent study. A reference population (N=397) was included as the first reference group. In addition 106 patients whose sleep laboratory findings confirmed that they were not suffering from obstructive sleep apnea were then included as a second reference group. Data were gathered with a questionnaire which had to be filled out by the persons with obstructive sleep apnea (cases) and the referents themselves. In the assessment of occupational exposure the questionnaires were filled out by the subjects themselves, and a job-exposure matrix was also used. Data were analyzed using logistic regression to control for age, region, body mass index, cigarette smoking, and alcohol consumption. Results: None of the exposures were statistically significantly associated with obstructive sleep apnea. There was no correlation with occupation. Only current activities in service occupations revealed an increased odds ratio, 1.6 (95% confidence interval 1.1-2.4). Conclusions: No suggestion was found of an association between exposure to solvents and obstructive sleep apnea