Abdominal Wall Mycetoma Presented as Obstructed Incisional Hernia of Cesarean Section in Eastern Sudan

Mycetoma a worldwide disease frequently occurs in the tropics with the highest prevalence being in Africa. Madurella mycetomatis is the main causative organism of human eumycetoma in Sudan. The legs and feet were commonly the sites of the infection. A 22-year-old lady was presented with painful abdominal swelling around a previous caesarian section scar. A provisional diagnosis of obstructed incisional hernia was put. Histopathological examination revealed macroscopically four masses of soft tissue. Microscopic sections showed grains of Madurella mycetomatis

Colorectal Polyps In Sudanese Patients( A Clinico-Pathological Study )

Background: Polyps are common diseases affecting the large bowel with high morbidity both in developed and developing countries. Design: This study is cross-sectional archival one. Setting: The study was conducted on 160 of Sudanese patients with colorectal polyps during the period from January 2006 to December 2009, at Soba University Hospital, in Sudan. One hundred and twelve (70%) were males, compared with 48(30%) females. Objectives: The study had the objectives to review the histopathological patterns of the colorectal polyps, to determine their anatomical locations, and to show the degree of dysplasia within the adenomatous polyps. Methods: Data were collected from patients request forms into predesigned questionnaire with detailed personal, clinical and pathological data. The slides were collected and reviewed by investigator and supervisor. The data were analyzed electronically using computer program , SPSS. Please purchase PDFcamp Printer on http://www.verypdf.com/ to remove this watermark. VI Results: Sudanese patients share many pathological and epidemiological features of the other countries for colorectal polyps: these include the tendency of the polyps to be located in the distal colon regardless of their histological types. Histological type is age related (P value = 0.000), (hamartomatous common in children, adenomatous, inflammatory and hyperplastic polyps are common in adults). The degree of the dysplasia within adenomatous polyps is related to their size (P value = 0.014), (severe degree of dysplasia within large polyps, mild degree in small polyps). Conclusion: The results of the study go well with the findings in the world literature, but we have a lot of missed data regarding history. We recommended that more studies to be carried out for more evaluation of the clinicopathological characteristics of colorectal polyps

IT security consultancy in Malaysia: hindrances and impacts

The dramatic progress in information technology has been followed by a remarkable increase in information security risks. Therefore, companies and organizations especially in developed countries have resorted to security consultant firms to secure their information systems and to help them build an effective security strategy. However, the situation is somewhat different in developing countries. Companies and organizations in developing countries tend to rely on their internal staff to handle the security issues instead of hiring IT security consultants. The purpose of this study is to examine the factors that hinder Malaysian companies and organizations from hiring information security consultants. Moreover, the study aims to investigate the implications and information security risks that these companies and organizations face. Questionnaires are administered and interviews were conducted amongst Ten Malaysian Companies and organizations from different sectors. The results of this study revealed that 70% of the companies and organizations do not have security consultants compared to 30% of the companies and organizations which hired security consultant firms to handle the critical information security issues

Detection of H. Pylori by Different Conventional Staining Methods and Immunohistochemistry in Sudanese Patients with Chronic Gastritis

Abstract Background: H.pylori is a major cause of chronic gastritis, peptic ulcer and gastric cancer, i

In Silico Evaluation of the Potential Association of the Pathogenic Mutations of Alpha Synuclein Protein with Induction of Synucleinopathies

Alpha synuclein (α-Syn) is a neuronal protein encoded by the SNCA gene and is involved in the development of Parkinson’s disease (PD). The objective of this study was to examine in silico the functional implications of non-synonymous single nucleotide polymorphisms (nsSNPs) in the SNCA gene. We used a range of computational algorithms such as sequence conservation, structural analysis, physicochemical properties, and machine learning. The sequence of the SNCA gene was analyzed, resulting in the mapping of 42,272 SNPs that are classified into different functional categories. A total of 177 nsSNPs were identified within the coding region; there were 20 variants that may influence the α-Syn protein structure and function. This identification was made by employing different analytical tools including SIFT, PolyPhen2, Mut-pred, SNAP2, PANTHER, PhD-SNP, SNP&Go, MUpro, Cosurf, I-Mut, and HOPE. Three mutations, V82A, K80E, and E46K, were selected for further examinations due to their spatial positioning within the α-Syn as determined by PyMol. Results indicated that these mutations may affect the stability and function of α-Syn. Then, a molecular dynamics simulation was conducted for the SNCA wildtype and the four mutant variants (p.A18G, p.V82A, p.K80E, and p.E46K). The simulation examined temperature, pressure, density, root-mean-square deviation (RMSD), root-mean-square fluctuation (RMSF), solvent-accessible surface area (SASA), and radius of gyration (Rg). The data indicate that the mutations p.V82A, p.K80E, and p.E46K reduce the stability and functionality of α-Syn. These findings highlight the importance of understanding the impact of nsSNPs on α-syn structure and function. Our results required verifications in further protein functional and case–control studies. After being verified these findings can be used in genetic testing for the early diagnosis of PD, the evaluation of the risk factors, and therapeutic approaches