Estudo clínico evolutivo da leishmaniose em área endêmica de Leishnania braziliensis braziliensis, Três Braços, Bahia

Dissertação (mestrado) — Universidade de Brasília, Faculdade de Medicina, Pós-graduação em Medicina Tropical, 2018.Foram estudadas as características clínicas evolutivas de 239 pacientes portadores de leishmaniose tegumentar que vivem em Três Braços, Bahia, área endêmica da doença.Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq); Ministério da Saúde (MS); World Bank/WHO Special Prograrame for Research and Training in Tropical Diseases e U.S. Public Health Service AI .The clinicai characteristics and initial course of were studied in 239 patients with cutaneous leishmaniasis from the endemic area of Três Braços, Bahia

Risk factors associated with the transmission of Andean cutaneous leishmaniasis

Thesis, University of London, 1993Includes abstract in FrenchThis is a population-based case-control study of the risk factors associated with the transmission of Andean cutaneous leishmaniasis (uta) with a concurrent design comparing persons who developed uta against persons who did not. Cases and controls were matched by age, sex and place of residence. The unit of analysis was the on-semester. The main exposure groups were: characteristics of the house, environmental characteristics around the house, and behaviour patterns of people. The study was carried out in five endemic regions of Peru. 187 cases and 335 controls were admitted to the study. Using matched and conditional logistic regression, in study areas of Lima & Ancash (region l) and Piura (region 2) Departments we have identified risk factors which imply that transmission occurs (a) inside houses, (b) outside but close to houses, (c) around houses, but not clearly indoors or outdoors, and (d) away from houses. In region 1 we found three risk factors of type a, using a kerosene lamp (OR=6.6, c.1.:2.2-19.7), having a chimney (OR=4.9, c.i.: 1.9-12.5) and living in a stone house (OR=2.9, c.i.: 1.6-5.2), one of type b, cutting wood (OR=7.4, c.i.:2.1-26.4). and three of type c, living in a house> 30m from road (OR=3.9, c.i.:l.4-10.7). with a vegetable garden (OR=2.8, c.i.: 1.1-4.1) and living in a house having> 6 persons (OR=4.2, c.i.: 1.9-9. 7). In region 2, we found four risk factors of type c. living in a house having an earth floor (OR=2.3, c.i.: 1.1-4. 7), with cows (OR=1.3, c.i.:l.1-1.6) and a neighbouring vegetable garden nearby (OR=2.9, c.i.: 1.3-6.9). and living > 30 m from a river (OR=3.3, c.1.:3.1-8.4), and one of type d, doing irrigation work at night (0R=2.2, c.i.: 1.2-4.2). The variability of risk factors between regions 1 and 2 can be explained by differences in (i) the frequency of exposures and (ii) the importance of factors. We conclude from OR's and PAR's that much transmission occurs around houses. Certainly, some transmission is indoors: the population attributable risk for factors associated with indoor transmission in region 1 was 79%, suggesting the possibility of uta control by preventing biting in houses. It remains questionable how much transmission goes on outdoors

Attempts using cryotherapy to achieve more rapid healing in patients with cutaneous leishmaniasis due to L. braziliensis braziliensis

The use of cryotherapy as an adjunct to systemic antimonial therapy (Clucantime) was studied in 17 patients with a total of23 skin lesions of leishmaniasis in an area where L. braziliensis braziliensis is the species in circulation. Cryotherapy did not speed healing and has been discarded as an auxiliary therapeutic measure in our practice. However this technique may be suitable for species o/Leishmania causing more limited superficial lesions in man without the danger of metastasis

Attempts using cryotherapy to achieve more rapid healing in patients with cutaneous leishmaniasis due to L. braziliensis braziliensis

The use of cryotherapy as an adjunct to systemic antimonial therapy (Clucantime) was studied in 17 patients with a total of23 skin lesions of leishmaniasis in an area where L. braziliensis braziliensis is the species in circulation. Cryotherapy did not speed healing and has been discarded as an auxiliary therapeutic measure in our practice. However this technique may be suitable for species o/Leishmania causing more limited superficial lesions in man without the danger of metastasis

What caused the 2012 dengue outbreak in Pucallpa, Peru? : a socio-ecological autopsy : pre-print version

Link to published version provided.Dengue is highly endemic in Peru, showing increases in transmission particularly since vector re-infestation of the country in the 1980s. This study suggests that the 2012 Pucallpa outbreak was proximally triggered by the introduction of a new virus serotype (DENV-2 Asian/America). Increased travel, rapid urbanization, and inadequate water management facilitated the potential for transmission. These triggers occurred within the context of failures in surveillance and control programming, including underfunded and ad hoc vector control. The findings have implications for future prevention and control of dengue in Ucayali region where chikungunya and Zika diseases are emerging