Comparison of sevoflurane and isoflurane effects on cardiovascular and respiratory system during spontaneous ventilation in Angora goats

KUMANDAS, ALI/0000-0002-7679-2126WOS: 000359122700018Seven healthy Angora goats were used to compare the effects of isoflurane and sevoflurane on the cardiovascular and respiratory systems during anesthesia periods. Once anesthesia was induced with propofol at 5.1 +/- 0.9 mg/kg, it was maintained with isoflurane at 1%-3% in the first treatment period and sevoflurane at 2%-4% in the second treatment period after a 15-day interval. Heart rates measured immediately after anesthesia induction and 5 min later were found to be statistically significant between anesthetic groups (P < 0.05). Mean blood pressure in the isoflurane group decreased (75.7 +/- 7.2 to 59.8 +/- 9.8 mmHg) (P < 0.05) throughout the anesthesia period. It was determined that respiratory rate in sevoflurane treatment was lower than that in isoflurane treatment. In terms of time to stand up, sevoflurane-administered animals recovered significantly faster than animals intubated with isoflurane anesthesia (13.1 +/- 4.4 and 25.0 +/- 8.6 min) (P < 0.05). According to cardiopulmonary values, the respiratory rate was lower in the sevoflurane-applied animals compared to that of those receiving isoflurane anesthesia, although the difference was not statistically significant, and hypercapnia were not observed in either group. Consequently, it was determined that in the Angora goat, propofol-sevoflurane anesthesia exerts lower pressure on the cardiovascular system than isoflurane anesthesia. At the same time, recovery from sevoflurane anesthesia was shorter, and therefore it can be preferred to other anesthesia agents for routine anesthesia.Kirikkale University Scientific Research Project Coordination Unit (KUBAP)Kirikkale University [2009/02]This study was supported by the Kirikkale University Scientific Research Project Coordination Unit (KUBAP No: 2009/02)

The Effects of Ketoprofen and Meloxicam on Bone Healing in Rat Model: A Comparative Dual Energy X-Ray Absorptiometry Study

KUMANDAS, ALI/0000-0002-7679-2126WOS: 000305923500024Pain control is a common clinical approach in trauma and postoperative care especially complicated orthopedic surgeries to ease the deleterious effects of pain. Various kinds of pain killers have been used, and nowadays nonsteroidal anti-inflammatory drugs (NSAIDs) are among the most commonly used drugs for pain control purposes. Prostaglandin-endoperoxide synthetase, also commonly called cyclooxygenase (COX), is one of the key enzymes in prostaglandin bio-synthesis. The COX enzymes have subgroups of enzymes, each of which suppresses different inflammatory mediators. These enzymes are involved in different functions, some of which are essential for continuity of physiological processes. Thus, NSAIDs are expected not to cause any change of functions of some enzymes while suppressing others. Among the COX enzymes, COX-1 is associated with gastrointestinal system functions and gastrointestinal mucosa while COX-2 is associated with inflammation and pain. Like most drugs, NSAIDs have known and possible side effects. In various studies related to NSAIDs, inhibitory effects of conventional NSAIDs with non-selective effects and specific COX-2 inhibitors on bone healing have been reported. In this study, the effects of ketoprofen and meloxicam on bone fracture healing induced in 24 adult male Wistar rats was studied by Dual Energy X-Ray Absorptiometry (DEXA). The results indicates that meloxicam inhibits the fracture healing to some degree.Scientific Research Project Coordination Unit of Kirikkale UniversityKirikkale UniversityThis research was supported by the Scientific Research Project Coordination Unit of Kirikkale Universit

Comparison of the effects of zinc-silver cream and Nigella sativa oil on wound healing and oxidative stress in the wound model in rats

WOS: 000504656100005The present study was undertaken to evaluate of Nigella sativa oil (NSO) and zinc-silver cream in a rat model of wound healing by means of clinical appearance, histopathology, oxidative stress parameters, and biomechanical tests. The rats were divided into three groups, each having twenty animals. Group 1 served as a control having wound. Other two groups received either NS oil or zinc-silver cream in addition to the wound. The study was initiated after the animals rested for 2 weeks for acclimation. Blood samples were collected from 10 randomly selected animals from each group at days 0, 3, 7 and 14 for oxidative stress measurements. Differences among groups for blood lipid peroxidation and antioxidant values were determined with respect to biochemical oxidative stress results (P<0.01). Wound sites of 10 animals from each group were allocated for histopathological examinations, and those of the remaining 10 animals from each group were used in biomechanical testing._Histopathological examination revealed that epithelization occurred in all groups. Inflammatory response with an intensive vascularization was present in the samples of the silver group (P<0.01). Consequently, zinc-silver group has differed positively in terms of biochemical and biomechanical and histological aspects compared to other groups for wound healing and oxidative stress.Kirikkale University Scientific Research Project Coordination Unit (KUBAP)Kirikkale University [2013 / 80]This study was supported by the Kirikkale University Scientific Research Project Coordination Unit (KUBAP No: 2013 / 80)

Comparison of the Efficacy of Gutta-percha and Thermafil in Endodontic Treatment in Dogs

KUMANDAS, ALI/0000-0002-7679-2126;WOS: 000294652200013Endodontic treatment is performed to save periodontally intact teeth with pulpal inflammation, infection or necrosis. There are some endodontic filling materials used in dogs. The aim of this study was to evaluate the clinical application of two different root canal treatments with thermafil and gutta-percha, in dogs. Nineteen tooth roots were treated in 11 dogs. The treated teeth comprised of six first incisors, five second incisors, three third incisors and five canine teeth. Root canal treatment was decided to be performed after clinical and radiological examination. The depth of the gingival sulcus, dental mobility, haemorrhage after probing and change of tooth colour were assessed and periapical lesions and root resorption were evaluated after dental radiographic examination. In clinical examination, exposed dental pulp, dental mobility, discoloration and fracture were recorded in 14, 3, 6 and 4 teeth, respectively. Periapical lesions were recorded in 4 teeth and root resorption was determined in 2 teeth during dental radiological examination. The root canal was filled with gutta-percha in 12 tooth roots and with thermafil in 7 tooth roots. Afterwards, access openings were closed with a composite resin. Of the 12 tooth roots obturated with gutta-percha, 4 were filled with 55 mm long-gutta-percha plugs manufactured specifically for carnivores and the others were obturated with commercially available 25 mm-long gutta-percha plugs. Both techniques were observed to be applicable; however, obturation with thermafil proved to be much easier. As regards the time needed for application, thermafil was applied within shorter periods compared to gutta-percha. However, the results obtained showed that, instead of using gutta-percha cones and a file of the same size, it would be better to prefer a smaller size thermafil cone to obturate the full length of the root canal.Scientific Research Project Unit of Kirikkale UniversityKirikkale University [2007/23]This research was supported by the Scientific Research Project Unit of Kirikkale University (2007/23)

Comparison of Propofol-Remifentanil and Propofol-Fentanyl Anesthesia During Ovariohysterectomy in Dogs

KUMANDAS, ALI/0000-0002-7679-2126WOS: 000321753100006The aim of the study was to evaluate the cardiorespiratory and clinical effects of propofol and remifentanil anesthesia compared to propofol and fentanyl anesthesia during ovariohysterectomy in dogs. Sixteen healthy dogs were randomly assigned to two groups. After premedication with atropine, anesthesia was induced with propofol and maintained with the infusion of propofol at a dose of 0.5 mg/kg/min. Once stable anesthesia was achieved, 1 mu g/kg remifentanil or 2 mu g/kg fentanyl was administered intravenously, and infusion was begun at a dose of 0.6 mu g/kg/min and 0.5 mu g/kg/min, respectively. Cardiorespiratory variables were recorded after propofol administration combined with remifentanil or fentanyl at 10-min intervals, and the quality of anesthesia, return of spontaneous ventilation, head lift and sternal position were also recorded. Apnea was observed after remifentanil and fentanyl administration in all dogs. Heart rate, systolic and mean arterial blood pressures tended to decrease rapidly after remifentanil and fentanyl administration, and during the first 20 min, in both groups. Although the difference between times was significant, the difference between groups was statistically insignificant. Recovery periods were longer in the fentanyl group than in the remifentanil group. The administration of propofol with remifentanil or fentanyl provides a stable haemodynamic state and depth of anesthesia with a constant infusion, and remifentanil could be preferred to fentanyl when aiming a rapid recovery period