9,904 research outputs found
'We nicked stuff from all over the place': policy transfer or muddling through?
This article explores current thinking about policy learning and transfer, using recent work on the 'Americanisation' of UK active labour market policies as a focus of discussion. While it is clear that the UK has learned from the US in certain respects, academic debates about the US-UK policy relationship are marked by accounts of learning and transfer that depend on a highly rational interpretation of these processes. The article reviews current debates in the policy transfer literature and applies a critical view of policy learning and transfer to key accounts of labour market activation policies before moving on to consider how useful the concept of policy transfer really is in an increasingly complex, plural and 'de-institutionalising' world
Concordant cues in faces and voices: testing the backup signal hypothesis
Information from faces and voices combines to provide multimodal signals about a person. Faces and voices may offer redundant, overlapping (backup signals), or complementary information (multiple messages). This article reports two experiments which investigated the extent to which faces and voices deliver concordant information about dimensions of fitness and quality. In Experiment 1, participants rated faces and voices on scales for masculinity/femininity, age, health, height, and weight. The results showed that people make similar judgments from faces and voices, with particularly strong correlations for masculinity/femininity, health, and height. If, as these results suggest, faces and voices constitute backup signals for various dimensions, it is hypothetically possible that people would be able to accurately match novel faces and voices for identity. However, previous investigations into novel face–voice matching offer contradictory results. In Experiment 2, participants saw a face and heard a voice and were required to decide whether the face and voice belonged to the same person. Matching accuracy was significantly above chance level, suggesting that judgments made independently from faces and voices are sufficiently similar that people can match the two. Both sets of results were analyzed using multilevel modeling and are interpreted as being consistent with the backup signal hypothesis
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CO and CI maps of the starburst galaxy M82
The first map of an external galaxy in the 3P₁ - 3P0 fine-structure line of atomic carbon (CI) is presented towards the nucleus of the starbuster M82, and compared with the distinction of the CO J = 4 - 3 molecular emission. The CI traces features that are seen in lower transition CO maps, and shows that CI and the CO are well mixed and have similar spatial distributions. There are small differences between the CO J = 4 - 3 line and lower transition CO data towards the NE part of the molecular ring, where the emission is less prominent. The abundance ratio [CI]/[CO] across M82 is very high, with an average value ~ 0.5 across most of the nucleus, a factor at least 5 times that which is typical of dense molecular cloud cores seen in our own Galaxy. This means that on average, CI is overabundant towards M82. This result can be explained using models which provide enhancements to the CI abundance above normal Interstellar Medium values, a result of a greater cosmic ray flux in M82, or where there is substantial mixing of the gas
Bezlotoxumab for prevention of recurrent Clostridium difficile infection in patients at increased risk for recurrence
Background: Bezlotoxumab is a human monoclonal antibody against Clostridium difficile toxin B indicated to prevent C. difficile infection (CDI) recurrence (rCDI) in adults at high risk for rCDI. This post hoc analysis of pooled monocolonal antibodies for C.difficile therapy (MODIFY) I/II data assessed bezlotoxumab efficacy in participants with characteristics associated with increased risk for rCDI.
Methods: The analysis population was the modified intent-to-treat population who received bezlotoxumab or placebo (n = 1554) by risk factors for rCDI that were prespecified in the statistical analysis plan: age ≥65 years, history of CDI, compromised immunity, severe CDI, and ribotype 027/078/244. The proportion of participants with rCDI in 12 weeks, fecal microbiota transplant procedures, 30-day all cause and CDI-associated hospital readmissions, and mortality at 30 and 90 days after randomization were presented.
Results: The majority of enrolled participants (75.6%) had ≥1 risk factor; these participants were older and a higher proportion had comorbidities compared with participants with no risk factors. The proportion of placebo participants who experienced rCDI exceeded 30% for each risk factor compared with 20.9% among those without a risk factor, and the rCDI rate increased with the number of risk factors (1 risk factor: 31.3%; ≥3 risk factors: 46.1%). Bezlotoxumab reduced rCDI, fecal microbiota transplants, and CDI-associated 30-day readmissions in participants with risk factors for rCDI.
Conclusions: The risk factors prespecified in the MODIFY statistical analysis plan are appropriate to identify patients at high risk for rCDI. While participants with ≥3 risk factors had the greatest reduction of rCDI with bezlotoxumab, those with 1 or 2 risk factors may also benefit.
Clinical Trials Registration: NCT01241552 (MODIFY I) and NCT01513239 (MODIFY II)
How South Pacific mangroves may respond to predicted climate change and sea level rise
In the Pacific islands the total mangrove area is about 343,735 ha, with largest areas in Papua New Guinea, Solomon Islands, Fiji and New Caledonia. A total of 34 species of mangroves occur, as well as 3 hybrids. These are of the Indo-Malayan assemblage (with one exception), and decline in diversity from west to east across the Pacific, reaching a limit at American Samoa. Mangrove resources are traditionally exploited in the Pacific islands, for construction and fuel wood, herbal medicines, and the gathering of crabs and fish.
There are two main environmental settings for mangroves in the Pacific, deltaic and estuarine mangroves of high islands, and embayment, lagoon and reef flat mangroves of low islands. It is indicated from past analogues that their close relationship with sea-level height renders these mangrove swamps particularly vulnerable to disruption by sea-level rise. Stratigraphic records of Pacific island mangrove ecosystems during sea-level changes of the Holocene Period demonstrate that low islands mangroves can keep up with a sea-level rise of up to 12 cm per 100 years. Mangroves of high islands can keep up with rates of sea-level rates of up to 45 cm per 100 years, according to the supply of fluvial sediment. When the rate of sea-level rise exceeds the rate of accretion, mangroves experience problems of substrate erosion, inundation stress and increased salinity.
Rise in temperature and the direct effects of increased CO2 levels are likely to increase mangrove productivity, change phenological patterns (such as the timing of flowering and fruiting), and expand the ranges of mangroves into higher latitudes.
Pacific island mangroves are expected to demonstrate a sensitive response to the predicted rise in sea-level. A regional monitoring system is needed to provide data on ecosystem changes in productivity, species composition and sedimentation. This has been the intention of a number of programs, but none has yet been implemented
The host galaxy of GRB010222: The strongest damped Lyman-alpha system known
Analysis of the absorption lines in the afterglow spectrum of the gamma-ray
burst GRB010222 indicates that its host galaxy (at a redshift of z=1.476) is
the strongest damped Lyman-alpha (DLA) system known, having a very low
metallicity and modest dust content. This conclusion is based on the detection
of the red wing of Lyman-alpha plus a comparison of the equivalent widths of
ultraviolet Mg I, Mg II, and Fe II lines with those in other DLAs. The column
density of H I, deduced from a fit to the wing of Lyman-alpha, is (5 +/- 2)
10^22 cm^-2. The ratio of the column densities of Zn and Cr lines suggests that
the dust content in our line of sight through the galaxy is low. This could be
due to either dust destruction by the ultraviolet emission of the afterglow or
to an initial dust composition different to that of the diffuse interstellar
material, or a combination of both.Comment: Submitted to MNRAS 12 page
Nonthermal X-Rays from Supernova Remnant G330.2+1.0 and the Characteristics of its Central Compact Object
We present results from our X-ray data analysis of the SNR G330.2+1.0 and its
CCO, CXOU J160103.1--513353 (J1601). Using our XMM-Newton and Chandra
observations, we find that the X-ray spectrum of J1601 can be described by
neutron star atmosphere models (T ~ 2.5--3.7 MK). Assuming the distance of d ~
5 kpc for J1601 as estimated for SNR G330.2+1.0, a small emission region of R ~
1--2 km is implied. X-ray pulsations previously suggested by Chandra are not
confirmed by the XMM-Newton data, and are likely not real. However, our timing
analysis of the XMM-Newton data is limited by poor photon statistics, and thus
pulsations with a relatively low amplitude (i.e., an intrinsic pulsed-fraction
< 40%) cannot be ruled out. Our results indicate that J1601 is a CCO similar to
that in the Cassiopeia A SNR.X-ray emission from SNR G330.2+1.0 is dominated by
power law continuum (Gamma ~ 2.1--2.5) which primarily originates from thin
filaments along the boundary shell. This X-ray spectrum implies synchrotron
radiation from shock-accelerated electrons with an exponential roll-off
frequency ~ 2--3 x 10^17 Hz. For the measured widths of the X-ray filaments (D
~ 0.3 pc) and the estimated shock velocity (v_s ~ a few x 10^3 km s^-1), a
downstream magnetic field B ~ 10--50 G is derived. The estimated maximum
electron energy E_max ~ 27--38 TeV suggests that G330.2+1.0 is a candidate TeV
gamma-ray source. We detect faint thermal X-ray emission in G330.2+1.0. We
estimate a low preshock density n_0 ~ 0.1 cm^-3, which suggests a dominant
contribution from an inverse Compton mechanism (than the proton-proton
collision) to the prospective gamma-ray emission. Follow-up deep radio, X-ray,
and gamma-ray observations will be essential to reveal the details of the shock
parameters and the nature of particle accelerations in this SNR.Comment: 26 pages, 3 tables, 7 figures (4 color figures), Accepted by Ap
A realistic double many-body expansion potential energy surface for from a multiproperty fit to accurate ab initio energies and vibrational levels
A single-valued double many-body expansion potential energy surface (DMBE I) recently obtained for the ground electronic state of the sulfur dioxide molecule by fitting correlated ab initio energies suitably corrected by scaling the dynamical correlation energy is now refined by fitting simultaneously available spectroscopic levels up to 6886 cm-1 above the minimum. The topographical features of the novel potential energy surface (DMBE II) are examined in detail, and the method is emphasized as a robust route to fit together state-of-the-art theoretical calculations and spectroscopic measurements using a single fully dimensional potential form.http://www.sciencedirect.com/science/article/B6VNG-44JJ0TT-5/1/c39f816ff06826dc517ad62441e91b5
Dust-driven Dynamos in Accretion Disks
Magnetically driven astrophysical jets are related to accretion and involve
toroidal magnetic field pressure inflating poloidal magnetic field flux
surfaces. Examination of particle motion in combined gravitational and magnetic
fields shows that these astrophysical jet toroidal and poloidal magnetic fields
can be powered by the gravitational energy liberated by accreting dust grains
that have become positively charged by emitting photo-electrons. Because a dust
grain experiences magnetic forces after becoming charged, but not before,
charging can cause irreversible trapping of the grain so dust accretion is a
consequence of charging. Furthermore, charging causes canonical angular
momentum to replace mechanical angular momentum as the relevant constant of the
motion. The resulting effective potential has three distinct classes of
accreting particles distinguished by canonical angular momentum, namely (i)
"cyclotron-orbit", (ii) "Speiser-orbit", and (iii) "zero canonical angular
momentum" particles. Electrons and ions are of class (i) but depending on mass
and initial orbit inclination, dust grains can be of any class. Light-weight
dust grains develop class (i) orbits such that the grains are confined to
nested poloidal flux surfaces, whereas grains with a critical weight such that
they experience comparable gravitational and magnetic forces can develop class
(ii) or class (iii) orbits, respectively producing poloidal and toroidal field
dynamos.Comment: 70 pages, 16 figure
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