Flax as a rotation crop in the higher rainfall areas of Western Australia

FLAX variety trials have been in progress at Bramley Research Station for three seasons and at Manjimup for two seasons, to determine if this crop would be a suitable cash rotation one. The results of these experiments were published earlier under the title of Flax Variety Experiment at Bramley and Manjimup, 1955-57, by Messrs. H. G. Elliott and F. E. Rya

Flax variety experiments at Bramley and Manjimup 1955-57

Early in 1955 it was decided to conduct flax variety trials in the higher rainfall areas of this State to determine what yields of straw and what percentage of fibre could be obtained. The first trial was conducted at Bramley Research Station and was continued for three years—the second of the series was conducted at Manjimup commencing in 1956 and continued in 1957. Details of these experiments are given below

Lawns : their establishment and management

THERE is nothing more pleasing to the eye than a well kept lawn, be it in a home garden or covering a sporting area, and under Western Australian conditions there is no reason why a good lawn or turf cannot be developed and maintained—always provided that there is enough water and proper care and attention

Flax trials, 1956-57

In overseas countries where flax is grown for fibre it is planted at higher rates of seeding, closer row spacing and higher rates of fertiliser, particularly potash, are used, than in this State. Early in 1956 it was decided to carry out some exploratory trials with fibre flax in the Boyup Brook district, to determine the effects of rates of seeding, drill spacing, together with rates of potash on the yields of flax straw, as well as yield and quality of the fibre produced from the straw with the various treatments. Trials were carried out in 1956-5

THP-1 macrophage cholesterol efflux is impaired by palmitoleate through Akt activation.

Lipoprotein lipase (LPL) is upregulated in atherosclerotic lesions and it may promote the progression of atherosclerosis, but the mechanisms behind this process are not completely understood. We previously showed that the phosphorylation of Akt within THP-1 macrophages is increased in response to the lipid hydrolysis products generated by LPL from total lipoproteins. Notably, the free fatty acid (FFA) component was responsible for this effect. In the present study, we aimed to reveal more detail as to how the FFA component may affect Akt signalling. We show that the phosphorylation of Akt within THP-1 macrophages increases with total FFA concentration and that phosphorylation is elevated up to 18 hours. We further show that specifically the palmitoleate component of the total FFA affects Akt phosphorylation. This is tied with changes to the levels of select molecular species of phosphoinositides. We further show that the total FFA component, and specifically palmitoleate, reduces apolipoprotein A-I-mediated cholesterol efflux, and that the reduction can be reversed in the presence of the Akt inhibitor MK-2206. Overall, our data support a negative role for the FFA component of lipoprotein hydrolysis products generated by LPL, by impairing macrophage cholesterol efflux via Akt activation

Majorana Neutrino Mixing

The most plausible see-saw explanation of the smallness of the neutrino masses is based on the assumption that total lepton number is violated at a large scale and neutrinos with definite masses are Majorana particles. In this review we consider in details difference between Dirac and Majorana neutrino mixing and possibilities of revealing Majorana nature of neutrinos with definite masses

Characterisation of feline renal cortical fibroblast cultures and their transcriptional response to transforming growth factor beta 1

Chronic kidney disease (CKD) is common in geriatric cats, and the most prevalent pathology is chronic tubulointerstitial inflammation and fibrosis. The cell type predominantly responsible for the production of extra-cellular matrix in renal fibrosis is the myofibroblast, and fibroblast to myofibroblast differentiation is probably a crucial event. The cytokine TGF-β1 is reportedly the most important regulator of myofibroblastic differentiation in other species. The aim of this study was to isolate and characterise renal fibroblasts from cadaverous kidney tissue of cats with and without CKD, and to investigate the transcriptional response to TGF-β1

Compassionate care in the community: reflections of a student nurse.

Reflecting on practice and analysing situations when compassionate care has been delivered can be a valuable way of helping student nurses develop their understanding of humanising care. This exemplar showcases a scenario when a second-year student nurse studying for a BSc (Honours) in adult nursing explored an experience while working in the community. She critically reflected on an incident highlighting a simple yet powerful example of how she helped an older couple manage an aspect of their care. This exercise helped the student to explore and understand what compassionate care means and highlighted how the value of reflection can be used to gain new insights to enhance the care of older people in her future practice in the community

Clonal architecture of secondary acute myeloid leukemia defined by single-cell sequencing

Next-generation sequencing has been used to infer the clonality of heterogeneous tumor samples. These analyses yield specific predictions-the population frequency of individual clones, their genetic composition, and their evolutionary relationships-which we set out to test by sequencing individual cells from three subjects diagnosed with secondary acute myeloid leukemia, each of whom had been previously characterized by whole genome sequencing of unfractionated tumor samples. Single-cell mutation profiling strongly supported the clonal architecture implied by the analysis of bulk material. In addition, it resolved the clonal assignment of single nucleotide variants that had been initially ambiguous and identified areas of previously unappreciated complexity. Accordingly, we find that many of the key assumptions underlying the analysis of tumor clonality by deep sequencing of unfractionated material are valid. Furthermore, we illustrate a single-cell sequencing strategy for interrogating the clonal relationships among known variants that is cost-effective, scalable, and adaptable to the analysis of both hematopoietic and solid tumors, or any heterogeneous population of cells

Geographically touring the eastern bloc: British geography, travel cultures and the Cold War

This paper considers the role of travel in the generation of geographical knowledge of the eastern bloc by British geographers. Based on oral history and surveys of published work, the paper examines the roles of three kinds of travel experience: individual private travels, tours via state tourist agencies, and tours by academic delegations. Examples are drawn from across the eastern bloc, including the USSR, Poland, Romania, East Germany and Albania. The relationship between travel and publication is addressed, notably within textbooks, and in the Geographical Magazine. The study argues for the extension of accounts of cultures of geographical travel, and seeks to supplement the existing historiography of Cold War geography