Preliminary design of a test rig for combining passive nonlinear isolation with active control

Resilient elements are typically used to isolate delicate equipment from a vibrating host structure. Conventionally, these isolators are designed to operate in their linear region, but more recently nonlinear isolators have been employed to increase the frequency over which vibration isolation can be achieved. Another way of improving the performance of an isolator has been to use active control in conjunction with a passive linear system. The work presented in this paper concerns the development of an experimental rig for vibration isolation and is motivated by the intention to combine the advantages of passive nonlinear isolation with active control.The structure consists of a mass suspended on four tensioned wires to form a single-degree-of-freedom system. The nonlinear stiffness of the wires is such that the system behaves like a hardening Duffing oscillator. Firstly, a static analysis is carried out, both analytically and experimentally, where the nonlinearity of the system is determined by the tension, length, cross-sectional area and Young’s modulus of the wires. For the dynamic analysis, harmonic base excitation is considered. The magnitude of the base displacement is fixed for all excitation frequencies and the level of nonlinearity is adjusted by varying the tension in the wires, a higher tension leading to a milder system nonlinearity. Finally, the motion transmissibility of the system is measured and appears to agree with the theoretical result. The rig forms a suitable platform for subsequent incorporation of an active control system for combining the benefits of passive nonlinear isolation with, for example, skyhook damping

Performance of the SASE amplifier of the TEU-FEL project

The free-electron laser of the TEU-FEL project of the University of Twente will be driven by a photoinjector followed by a racetrack microtron. The injector, which is now under construction, will provide a very high-brightness electron beam with an energy of about 6 MeV. In phase I of the project, experiments are being planned in which this low energy beam from the injector will pass through an undulator and will generate radiation at a wavelength of about 200 ¿m via the process of self-amplified spontaneous emission (SASE). Numerical simulations of the performance of this source indicate that power levels of about 15 MW (averaged over a micropulse) can be obtained with a 1-m undulator. We present additional results derived from simulation studies of the performance of this device

Teams and cardiac surgery

Motivation\ud Our study is designed to identify human factors that are a threat to the safety of children with heart disease.\ud \ud Research approach\ud After an initial observation period, we will apply a major safety intervention. We will then re-measure the occurrence and types of human factors in the operating room, and the incidence of adverse events, near misses and hospital death, to evaluate if there was a significant post-intervention reduction. \ud \ud Findings/design\ud We focus on challenges encountered during the training of the observers. Research Limitations\ud Because of the complexity of the OR, observations are necessarily subjective. \ud \ud Originality/Value\ud This work is original because of the systematic evaluation of a safety intevention and the training protocol for the observers.\ud \ud Take Away Message\ud Systematic and periodic assessment of observers is required when teamwork is observed in complex, dynamic settings

Active vibration control (AVC) of a satellite boom structure using optimally positioned stacked piezoelectric actuators

In this paper, results for active vibration control predicted from experimental measurements on a lightweight structure are compared with purely computational predictions. The structure studied is a 4.5m long satellite boom consisting of 10 identical bays with equilateral triangular cross sections. First, the results from a Fortran code that is based on a receptance analysis are validated against the experimental forced response of the boom structure. Exhaustive searches are then carried out to find the optimum positions for one and two actuators. Finally, a genetic algorithm is employed to find high-quality positions for three actuators on the structure that will achieve the greatest reductions in vibration transmission. Having found these actuator positions, experiments are then carried out to verify the quality of the theoretical predictions. It was found that the attenuation achievable in practice for one, two and three actuators were, respectively, 15.1, 26.1 and 33.5 dB

Active vibration control (AVC) of a satellite boom structure using optimally positioned stacked piezoelectric actuators

In this paper, results for active vibration control predicted from experimental measurements on a lightweight structure are compared with purely computational predictions. The structure studied is a 4.5m long satellite boom consisting of 10 identical bays with equilateral triangular cross sections. First, the results from a Fortran code that is based on a receptance analysis are validated against the experimental forced response of the boom structure. Exhaustive searches are then carried out to find the optimum positions for one and two actuators. Finally, a genetic algorithm is employed to find high-quality positions for three actuators on the structure that will achieve the greatest reductions in vibration transmission. Having found these actuator positions, experiments are then carried out to verify the quality of the theoretical predictions. It was found that the attenuation achievable in practice for one, two and three actuators were, respectively, 15.1, 26.1 and 33.5 dB

A tale of two cities: restoring water services in Kabul and Monrovia

Kabul and Monrovia, the respective capitals of Afghanistan and Liberia, have recently emerged from long-lasting armed conflicts. In both cities, a large number of organisations took part in emergency water supply provision and later in the rehabilitation of water systems. Based on field research, this paper establishes a parallel between the operations carried out in the two settings, highlighting similarities and analysing the two most common strategies. The first strategy involves international financial institutions, which fund large-scale projects focusing on infrastructural rehabilitation and on the institutional development of the water utility, sometimes envisaging private-sector participation. The second strategy involves humanitarian agencies, which run community-based projects, in most cases independently of the water utilities, and targeting low-income areas. Neither of these approaches manages to combine sustainability and universal service. The paper assesses their respective strengths and weaknesses and suggests ways of improving the quality of assistance provided

Decellularized diaphragmatic muscle drives a constructive angiogenic response in vivo

Skeletal muscle tissue engineering (TE) aims to efficiently repair large congenital and acquired defects. Biological acellular scaffolds are considered a good tool for TE, as decellularization allows structural preservation of tissue extracellular matrix (ECM) and conservation of its unique cytokine reservoir and the ability to support angiogenesis, cell viability, and proliferation. This represents a major advantage compared to synthetic scaffolds, which can acquire these features only after modification and show limited biocompatibility. In this work, we describe the ability of a skeletal muscle acellular scaffold to promote vascularization both ex vivo and in vivo. Specifically, chicken chorioallantoic membrane assay and protein array confirmed the presence of pro-angiogenic molecules in the decellularized tissue such as HGF, VEGF, and SDF-1\u3b1. The acellular muscle was implanted in BL6/J mice both subcutaneously and ortotopically. In the first condition, the ECM-derived scaffold appeared vascularized 7 days post-implantation. When the decellularized diaphragm was ortotopically applied, newly formed blood vessels containing CD31+, \u3b1SMA+, and vWF+ cells were visible inside the scaffold. Systemic injection of Evans Blue proved function and perfusion of the new vessels, underlying a tissue-regenerative activation. On the contrary, the implantation of a synthetic matrix made of polytetrafluoroethylene used as control was only surrounded by vWF+ cells, with no cell migration inside the scaffold and clear foreign body reaction (giant cells were visible). The molecular profile and the analysis of macrophages confirmed the tendency of the synthetic scaffold to enhance inflammation instead of regeneration. In conclusion, we identified the angiogenic potential of a skeletal muscle-derived acellular scaffold and the pro-regenerative environment activated in vivo, showing clear evidence that the decellularized diaphragm is a suitable candidate for skeletal muscle tissue engineering and regeneration

Current strategies for tracheal replacement: A review

Airway cancers have been increasing in recent years. Tracheal resection is commonly performed during surgery and is burdened from post-operative complications severely affecting quality of life. Tracheal resection is usually carried out in primary tracheal tumors or other neoplasms of the neck region. Regenerative medicine for tracheal replacement using bio-prosthesis is under current research. In recent years, attempts were made to replace and transplant human cadaver trachea. An effective vascular supply is fundamental for a successful tracheal transplantation. The use of biological scaffolds derived from decellularized tissues has the advantage of a three-dimensional structure based on the native extracellular matrix promoting the perfusion, vascularization, and differentiation of the seeded cell typologies. By appropriately modulating some experimental parameters, it is possible to change the characteristics of the surface. The obtained membranes could theoretically be affixed to a decellularized tissue, but, in practice, it needs to ensure adhesion to the biological substrate and/or glue adhesion with biocompatible glues. It is also known that many of the biocompatible glues can be toxic or poorly tolerated and induce inflammatory phenomena or rejection. In tissue and organ transplants, decellularized tissues must not produce adverse immunological reactions and lead to rejection phenomena; at the same time, the transplant tissue must retain the mechanical properties of the original tissue. This review describes the attempts so far developed and the current lines of research in the field of tracheal replacement