Water vapor lidar

The feasibility was studied of measuring atmospheric water vapor by means of a tunable lidar operated from the space shuttle. The specific method evaluated was differential absorption, a two-color method in which the atmospheric path of interest is traversed by two laser pulses. Results are reported

Adaptive Filters Revisited - RFI Mitigation in pulsar observations

Pulsar detection and timing experiments are applications where adaptive filters seem eminently suitable tools for radio-frequency-interference (RFI) mitigation. We describe a novel variant which works well in field trials of pulsar observations centred on an observing frequency of 675 MHz, a bandwidth of 64 MHz and with 2-bit sampling. Adaptive filters have generally received bad press for RFI mitigation in radio astronomical observations with their most serious drawback being a spectral echo of the RFI embedded in the filtered signals. Pulsar observations are intrinsically less sensitive to this as they operate in the (pulsar period) time domain. The field trials have allowed us to identify those issues which limit the effectiveness of the adaptive filter. We conclude that adaptive filters can significantly improve pulsar observations in the presence of RFI.Comment: Accepted for publication in Radio Scienc

Automated Quality Control for Genome Wide Association Studies

This paper provides details on the necessary steps to assess and control data in genome wide association studies (GWAS) using genotype information on a large number of genetic markers for large number of individuals. Due to varied study designs and genotyping platforms between multiple sites/projects as well as potential genotyping errors, it is important to ensure high quality data. Scripts and directions are provided to facilitate others in this process

Catalog of Galaxy Morphology in Four Rich Clusters: Luminosity Evolution of Disk Galaxies at 0.33<z<0.83

Hubble Space Telescope (HST) imaging of four rich, X-ray luminous, galaxy clusters (0.33<z<0.83) is used to produce quantitative morphological measurements for galaxies in their fields. Catalogs of these measurements are presented for 1642 galaxies brighter than F814W(AB)=23.0 . Galaxy luminosity profiles are fitted with three models: exponential disk, de Vaucouleurs bulge, and a disk-plus-bulge hybrid model. The best fit is selected and produces a quantitative assessment of the morphology of each galaxy: the principal parameters derived being B/T, the ratio of bulge to total luminosity, the scale lengths and half-light radii, axial ratios, position angles and surface brightnesses of each component. Cluster membership is determined using a statistical correction for field galaxy contamination, and a mass normalization factor (mass within boundaries of the observed fields) is derived for each cluster. In the present paper, this catalog of measurements is used to investigate the luminosity evolution of disk galaxies in the rich-cluster environment. Examination of the relations between disk scale-length and central surface brightness suggests, under the assumption that these clusters represent a family who share a common evolutionary history and are simply observed at different ages, that there is a dramatic change in the properties of the small disks (h < 2 kpc). This change is best characterized as a change in surface brightness by about 1.5 magnitude between z=0.3 and z=0.8 with brighter disks at higher redshifts.Comment: 53 pages, including 13 figures and 7 tables. Accepted for publication in the Astrophysical Journal Supplement Serie

Serial MR diffusion to predict treatment response in high-grade pediatric brain tumors: a comparison of regional and voxel-based diffusion change metrics

Background Assessment of treatment response by measuring tumor size is known to be a late and potentially confounded response index. Serial diffusion MRI has shown potential for allowing earlier and possibly more reliable response assessment in adult patients, with limited experience in clinical settings and in pediatric brain cancer. We present a retrospective study of clinical MRI data in children with high-grade brain tumors to assess and compare the values of several diffusion change metrics to predict treatment response. Methods Eighteen patients (age range, 1.9–20.6 years) with high-grade brain tumors and serial diffusion MRI (pre- and posttreatment interval range, 1–16 weeks posttreatment) were identified after obtaining parental consent. The following diffusion change metrics were compared with the clinical response status assessed at 6 months: (1) regional change in absolute and normalized apparent diffusivity coefficient (ADC), (2) voxel-based fractional volume of increased (fiADC) and decreased ADC (fdADC), and (3) a new metric based on the slope of the first principal component of functional diffusion maps (fDM). Results Responders (n = 12) differed significantly from nonresponders (n = 6) in all 3 diffusional change metrics demonstrating higher regional ADC increase, larger fiADC, and steeper slopes (P < .05). The slope method allowed the best response prediction (P < .01, η2 = 0.78) with a classification accuracy of 83% for a slope of 58° using receiver operating characteristic (ROC) analysis. Conclusions We demonstrate that diffusion change metrics are suitable response predictors for high-grade pediatric tumors, even in the presence of variable clinical diffusion imaging protocols

Design of Reconfigurable Rim Scattering Reflectarrays for Null Steering in Reflector Antennas

Reflector antennas are susceptible to interference arriving through its sidelobes. The design of a reconfigurable rim scattering reflectarray which can be retrofitted to existing high gain reflector antennas giving the reflector adaptive null steering capabilities is presented thereby giving the reflector interference mitigation capabilities. The conformal reflectarray, placed along the outer rim of the reflector antenna, contains reconfigurable unit cells (RUC). The states of the RUCs allow the reflectarray to place a null in any direction within the first few sidelobes of the reflector pattern. A 1-bit RUC containing two pin diodes with less than 0.44dB loss at the operating frequency is presented. It is found that the dielectric and switch losses do not significantly affect the overall efficiency of the reflector as they are placed only along the outer rim of the reflector which is weakly illuminated. Two reflectarrays are designed. First, a L-band non-reconfigurable reflectarray based on variable patch size for an 18m prime focus fed parabola is presented. A full-wave simulation of this design serves to validate the design approach. Subsequently, a reflectarray design using RUCs is presented. All necessary formulations for complete reproducibility of results are provided in appendices allowing for follow-on work