The impact of resilience among older adults

AbstractThe purpose of this literature review was to provide an overview of resilience for the purpose of informing potential intervention designs that may benefit older adults. While numerous reviews have focused on various specific aspects of resilience, none have provided the necessary information required to design an effective resilience intervention. Research examining resilience suggests that older adults are capable of high resilience despite socioeconomic backgrounds, personal experiences, and declining health. Thus opportunities to inform interventions in this area exist. Research studies have identified the common mental, social, and physical characteristics associated with resilience. High resilience has also been significantly associated with positive outcomes, including successful aging, lower depression, and longevity. Interventions to enhance resilience within this population are warranted, but little evidence of success exists. Thus this review provides an overview of resilience that may aid in the design of resilience interventions for the often underserved population of older adults

T1DBase: integration and presentation of complex data for type 1 diabetes research

T1DBase () [Smink et al. (2005) Nucleic Acids Res., 33, D544–D549; Burren et al. (2004) Hum. Genomics, 1, 98–109] is a public website and database that supports the type 1 diabetes (T1D) research community. T1DBase provides a consolidated T1D-oriented view of the complex data world that now confronts medical researchers and enables scientists to navigate from information they know to information that is new to them. Overview pages for genes and markers summarize information for these elements. The Gene Dossier summarizes information for a list of genes. GBrowse [Stein et al. (2002) Genome Res., 10, 1599–1610] displays genes and other features in their genomic context, and Cytoscape [Shannon et al. (2003) Genome Res., 13, 2498–2504] shows genes in the context of interacting proteins and genes. The Beta Cell Gene Atlas shows gene expression in β cells, islets, and related cell types and lines, and the Tissue Expression Viewer shows expression across other tissues. The Microarray Viewer shows expression from more than 20 array experiments. The Beta Cell Gene Expression Bank contains manually curated gene and pathway annotations for genes expressed in β cells. T1DMart is a query tool for markers and genotypes. PosterPages are ‘home pages’ about specific topics or datasets. The key challenge, now and in the future, is to provide powerful informatics capabilities to T1D scientists in a form they can use to enhance their research

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

BACKGROUND: Autoimmune disease-associated variants are preferentially found in regulatory regions in immune cells, particularly CD4+ T cells. Linking such regulatory regions to gene promoters in disease-relevant cell contexts facilitates identification of candidate disease genes. RESULTS: Within four hours, activation of CD4+ T cells invokes changes in histone modifications and enhancer RNA transcription that correspond to altered expression of the interacting genes identified by promoter capture Hi-C (PCHi-C). By integrating PCHi-C data with genetic associations for five autoimmune diseases we prioritised 245 candidate genes with a median distance from peak signal to prioritised gene of 153 kb. Just under half (108/245) prioritised genes related to activation-sensitive interactions. This included IL2RA, where allele-specific expression analyses were consistent with its interaction-mediated regulation, illustrating the utility of the approach. CONCLUSIONS: Our systematic experimental framework offers an alternative approach to candidate causal gene identification for variants with cell state-specific functional effects, with achievable sample sizes.This work was funded by the JDRF (9-2011-253), the Wellcome Trust (089989, 091157, 107881), the UK Medical Research Council (MR/L007150/1, MC_UP_1302/5), the UK Biotechnology and Biological Sciences Research Council (BB/J004480/1) and the National Institute for Health Research (NIHR) Cambridge Biomedical Research Centre. The research leading to these results has received funding from the European Union’s 7th Framework Programme (FP7/2007-2013) under grant agreement no. 241447 (NAIMIT). The Cambridge Institute for Medical Research (CIMR) is in receipt of a Wellcome Trust Strategic Award (100140)

Evaluating the feasibility of pangolin farming and its potential conservation impact

Pangolins are threatened by overexploitation for local and international use. They are subject to an international commercial trade ban, and are also the focus of other interventions, including attempts at commercial captive breeding. The impact that the latter could have on the conservation of wild populations deserves consideration. We critically evaluate the feasibility of commercial captive breeding (or farming) of pangolins to displace wild collection and assess its potential conservation impact on pangolin conservation using a recently published framework developed for this purpose. Of the 17 conditions posited that need to be met for supply-side interventions to displace wild collection, we find that pangolins meet a maximum of only six conditions. This analysis suggests that pangolin farming will not displace wild collection in the near future. Major barriers include an inability to breed pangolins on a commercial scale and available data suggest that it would be unprofitable. The immediate impact of pangolin farming on conservation of the species’ is unclear, but it is unlikely to benefit the conservation of wild populations. If commercial captive breeding were possible, it is uncertain how it would affect economic incentives for poaching, interactions between legal and illegal markets, stockpile policies, and how consumers and Traditional Chinese Medicine (TCM) practitioners would respond. To understand better the potential overall impact of pangolin farming on wild populations there is a need for further research on these uncertainties. The framework used has utility in analysing the potential impact of wildlife farming but there remains a need for a more robust approach to evaluate potential impacts of supplyside interventions.http://www.elsevier.com/locate/geccohb2020Mammal Research InstituteZoology and Entomolog

Evaluating the feasibility of pangolin farming and its potential conservation impact

Pangolins are threatened by overexploitation for local and international use. They are subject to an international commercial trade ban, and are also the focus of other interventions, including attempts at commercial captive breeding. The impact that the latter could have on the conservation of wild populations deserves consideration. We critically evaluate the feasibility of commercial captive breeding (or farming) of pangolins to displace wild collection and assess its potential conservation impact on pangolin conservation using a recently published framework developed for this purpose. Of the 17 conditions posited that need to be met for supply-side interventions to displace wild collection, we find that pangolins meet a maximum of only six conditions. This analysis suggests that pangolin farming will not displace wild collection in the near future. Major barriers include an inability to breed pangolins on a commercial scale and available data suggest that it would be unprofitable. The immediate impact of pangolin farming on conservation of the species’ is unclear, but it is unlikely to benefit the conservation of wild populations. If commercial captive breeding were possible, it is uncertain how it would affect economic incentives for poaching, interactions between legal and illegal markets, stockpile policies, and how consumers and Traditional Chinese Medicine (TCM) practitioners would respond. To understand better the potential overall impact of pangolin farming on wild populations there is a need for further research on these uncertainties. The framework used has utility in analysing the potential impact of wildlife farming but there remains a need for a more robust approach to evaluate potential impacts of supplyside interventions.http://www.elsevier.com/locate/geccohb2020Mammal Research InstituteZoology and Entomolog

Los servicios en los esquemas de integración: algunas consideraciones y opciones para Centroamérica: versión provisional

Incluye Bibliografí

Trends in Drain Utilization in Bariatric Surgery: an Analysis of the MBSAQIP Database 2015-2017.

BACKGROUND: Laparoscopic Roux-en-Y gastric bypass (LRYGB) and sleeve gastrectomy (SG) are the two most common bariatric operations. With the implementation of enhanced recovery protocols, the use of drains should decrease. METHODS: The Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program database was queried for the years 2015-2017. Our inclusion criteria included all patients undergoing a primary LRYGB, SG, and revisions. We examined demographics, operative characteristics, the use of drains, and postoperative complications. Continuous variables were summarized using means and standard deviations (SD). Categorical variables were summarized using frequencies and proportions. Student\u27s T test (Wilcoxon sum rank test in the case of skewed data) and chi-squared analysis were used to assess the baseline differences in drain utilization. RESULTS: From 2015 to 2017, there were 388,239 bariatric cases performed without drains and 100,221 performed with drains. Twenty-nine percent of LRYGB patients had a drain placed but only 16.7% of SG patients. The percentage of LRYGB that had a drain dropped from 33.1 to 24.6% during the study period and that of SG dropped from 20.3 to 13.6%. Patients that had drains placed were more likely to have a provocative test at the time of surgery (prevalence ratio (PR) 2.24) and to have a postoperative swallow study (PR 1.93). CONCLUSIONS: Drains are still commonly used in bariatric patients. Over the study period, there was a decrease in the use of drains in both bypass and sleeve patients. Patients with a drain were more likely to have had a provocative test and a swallow study and have a higher rate of complications and mortality