Additional file 3: Figure S1. of An epigenome-wide study of obesity in African American youth and young adults: novel findings, replication in neutrophils, and relationship with gene expression

Positions and correlations of the multiple CpG sites in SBNO2, SOCS3, VMP1, and CISH genes. (PDF 425 kb

The genetic underpinnings of variation in ages at menarche and natural menopause among women from the multi-ethnic Population Architecture using Genomics and Epidemiology (PAGE) Study: A trans-ethnic meta-analysis

<div><p>Current knowledge of the genetic architecture of key reproductive events across the female life course is largely based on association studies of European descent women. The relevance of known loci for age at menarche (AAM) and age at natural menopause (ANM) in diverse populations remains unclear. We investigated 32 AAM and 14 ANM previously-identified loci and sought to identify novel loci in a trans-ethnic array-wide study of 196,483 SNPs on the MetaboChip (Illumina, Inc.). A total of 45,364 women of diverse ancestries (African, Hispanic/Latina, Asian American and American Indian/Alaskan Native) in the Population Architecture using Genomics and Epidemiology (PAGE) Study were included in cross-sectional analyses of AAM and ANM. Within each study we conducted a linear regression of SNP associations with self-reported or medical record-derived AAM or ANM (in years), adjusting for birth year, population stratification, and center/region, as appropriate, and meta-analyzed results across studies using multiple meta-analytic techniques. For both AAM and ANM, we observed more directionally consistent associations with the previously reported risk alleles than expected by chance (p-values_binomial≤0.01). Eight densely genotyped reproductive loci generalized significantly to at least one non-European population. We identified one trans-ethnic array-wide SNP association with AAM and two significant associations with ANM, which have not been described previously. Additionally, we observed evidence of independent secondary signals at three of six AAM trans-ethnic loci. Our findings support the transferability of reproductive trait loci discovered in European women to women of other race/ethnicities and indicate the presence of additional trans-ethnic associations both at both novel and established loci. These findings suggest the benefit of including diverse populations in future studies of the genetic architecture of female growth and development.</p></div

Descriptive statistics for the age at menarche (AAM, n = 44,367) and natural menopause (ANM, n = 17,100) analytic samples.

<p>Descriptive statistics for the age at menarche (AAM, n = 44,367) and natural menopause (ANM, n = 17,100) analytic samples.</p

Generalization of five previously described age at menarche and natural menopause loci to multiple race/ethnic groups or trans-ethnically.

<p>Generalization of five previously described age at menarche and natural menopause loci to multiple race/ethnic groups or trans-ethnically.</p

Regional plots for age at menarche Bonferroni-significant loci at <i>SEC16B</i> (Panel A), <i>BDNF</i> (Panel B) and <i>FTO</i> (Panel C), showing previously published body mass index (BMI) primary and secondary SNP associations, using a modified random-effects trans-ethnic meta-analysis of more than 31,000 women.

<p>Regional plots for age at menarche Bonferroni-significant loci at <i>SEC16B</i> (Panel A), <i>BDNF</i> (Panel B) and <i>FTO</i> (Panel C), showing previously published body mass index (BMI) primary and secondary SNP associations, using a modified random-effects trans-ethnic meta-analysis of more than 31,000 women.</p

Regional plots of the novel array-wide significant age at menarche (Panel A: <i>CUX2</i>) and natural menopause loci (Panels B,C: <i>FRMD5</i>, <i>GPRC5B</i>) using a modified random-effects trans-ethnic meta-analysis of more than 31,000 women, and showing independence from previously published cardiometabolic SNP associations (shown in gray if missing).

<p>Regional plots of the novel array-wide significant age at menarche (Panel A: <i>CUX2</i>) and natural menopause loci (Panels B,C: <i>FRMD5</i>, <i>GPRC5B</i>) using a modified random-effects trans-ethnic meta-analysis of more than 31,000 women, and showing independence from previously published cardiometabolic SNP associations (shown in gray if missing).</p

Three loci with trans-ethnic array-wide significant modified random-effects associations^* at novel age at menarche or natural menopause loci.

<p>Three loci with trans-ethnic array-wide significant modified random-effects associations^{<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0200486#t004fn001" target="_blank">*</a>} at novel age at menarche or natural menopause loci.</p

Three densely-genotyped MetaboChip loci with Bonferroni-significant associations with age at menarche across multiple race/ethnic groups or trans-ethnically.

<p>Three densely-genotyped MetaboChip loci with Bonferroni-significant associations with age at menarche across multiple race/ethnic groups or trans-ethnically.</p

Intervention dans le Podcast les Arts du FLE pour faire le point sur la perspective actionnelle en classe de langues

Ce podcast est disponible en ligne, à l'adresse suivante :https://agi.to/podcast/arts-du-fle-08-actionne-ton-approche/Ce numéro 8 des Arts du FLE (émission spécialisée en FLE) propose un dossier spécial approches pédagogiques et perspective actionnelle. J'en suis l'invitée et j'y réponds de manière détaillée pendant près d'une heure aux questions de l'animateur et créateur de ce Podcast, Sébastien Durietz (en poste actuellement à l'ONU, à New-York)

Additional file 10: Table S9. of DNA methylation signatures of chronic low-grade inflammation are associated with complex diseases

Significant associations between DNA methylation and corresponding nearby genetic variants and between the genetic variant and CRP in the largest published GWAS of CRP (n = 66,185). (XLSX 12 kb