Terahertz Response of Field-Effect Transistors in Saturation Regime

We report on the broadband THz response of InGaAs/GaAs HEMTs operating at 1.63 THz and room temperature deep in the saturation regime. We demonstrate that responses show linear increase with drain-to-source voltage (or drain bias current) and reach very high values up to 170V/W. We also develop a phenomenological theory valid both in the ohmic and in the saturation regimes.Comment: 11 pages, 3 figure

A High-Throughput In Vitro Model Illustrating Potential Microbiologocal Interactions During Treatment of \u3cem\u3ePseudomonas aeroginosa\u3c/em\u3e Biofilm Associated Infections

Objective: Amend a real-time, high-throughput method of bacterial growth detection for use as a model of biofilm response to co-administered pharmaceuticals during the treatment of devise associated infections. Background: Biofilms are the root etiology for chronic infections, particularly in regard to infections in patients with implanted medical devices. Calcium channel blockers (CCBs) are used for control of hypertension and angina and are commonly prescribed to elderly patients. We address potential interference of commonly prescribed CCBs with levofloxacin for treatment of Pseudomonas aeruginosa biofilms. Methods: Inoculum of 1–3×106CFU∕mL in the log phase were seeded into each well of a polystyrene plate. Biofilms developed over 6h at 37°C, was washed and medium containing various CCBs plus levofloxacin was added to the biofilm. OD measurements were obtained at 1h intervals over 90h at 37°C. Changes in turbidity were kinetically measured with a vertical photometer with a wide-band filter. Results: Mibefradil and diltiazem appear to be strongly antagonistic toward levofloxacin where both of them decrease antibiofilm effect of levofloxacin and they encourage the selection of resistant mutants from biofilm. Discussion: Implanted medical devices are quite common and are subjected to biofilm infections. Increasing multi-drug resistance underscores the need to conserve current antibiotics by judicious use. This necessitates consideration of evidence regarding antagonistic or synergistic activity of commonly prescribed drugs of different classes toward commonly used antibiotics. The combinations described here show vital and previously unreported effects of some CCBs when co-prescribed with levofloxacin on Pseudomonas aeruginosa biofilm

Disaggregated Memory at the Edge

This paper describes how to augment techniques such as Distributed Shared Memory with recent trends on disaggregated Non Volatile Memory in the data centre so that the combination can be used in an edge environment with potentially volatile and mobile resources. This article identifies the main advantages and challenges, and offers an architectural evolution to incorporate recent research trends into production-ready disaggregated edges. We also present two prototypes showing the feasibility of this proposal

Heads in the cloud:innovation in data and model dissemination

Utilising environmental data to better support decision making is a complex task. The Environmental Virtual Observatory pilot project has demonstrated that a multidisciplinary approach to making integrated data and modelling services available via new cloud technologies offers a way forward

Energy Efficient Smart Wireless Sensor Network for Border Monitoring

The main concern of wireless sensor network is the flexibility and the power to execute different control tasks. This paper presents low power flexible controller for an intrusion detection using power gating technique to reduce the static power loss and fuzzy logic controller, the input signals are proceeded from a PIR, an acoustic and magnetic sensors, the output is presented as an alarm to define the kind of the intrusion. The system behavior is simulated using MATALB-SIMULINK

Cumulative clinical experience from over a decade of use of levofloxacin in community-acquired pneumonia: critical appraisal and role in therapy

Levofloxacin is the synthetic L-isomer of the racemic fluoroquinolone, ofloxacin. It interferes with critical processes in the bacterial cell such as DNA replication, transcription, repair, and recombination by inhibiting bacterial topoisomerases. Levofloxacin has broad spectrum activity against several causative bacterial pathogens of community-acquired pneumonia (CAP). Oral levofloxacin is rapidly absorbed and is bioequivalent to the intravenous formulation such that patients can be conveniently transitioned between these formulations when moving from the inpatient to the outpatient setting. Furthermore, levofloxacin demonstrates excellent safety, and has good tissue penetration maintaining adequate concentrations at the site of infection. The efficacy and tolerability of levofloxacin 500 mg once daily for 10 days in patients with CAP are well established. Furthermore, a high-dose (750 mg) and short-course (5 days) of once-daily levofloxacin has been approved for use in the US in the treatment of CAP, acute bacterial sinusitis, acute pyelonephritis, and complicated urinary tract infections. The high-dose, short-course levofloxacin regimen maximizes its concentration-dependent antibacterial activity, decreases the potential for drug resistance, and has better patient compliance

Improvement of Bioconversion of Vitamin D3 into Calcitriol by Actinomyces hyovaginalis through Protoplast Fusion and Enzyme Immobilization

Protoplast fusion and enzyme immobilization techniques were applied to increase calcitriol production from vitamin D3 using Actinomyces hyovaginalis, a local isolate recovered from Egyptian soil, that has a potential bioconversion activity of vitamin D3 into calcitriol. A total of sixteen protoplast hybrids, formed between Actinomyces hyovaginalis isolate and two Bacillus species (B. thuringiensis and B. weihenstephanensis) were screened for vitamin D3 bioconversion activity. Compared to wild type isolate, four hybrids (formed between Actinomyces hyovaginalis isolate and B. thuringiensis) were found to preserve the bioconversion activity; out of which, three hybrids coded V2B, V3B and V8A exhibited higher calcitriol production. The hybrids coded V2B and V8A produced, per 1 L culture medium, about 0.5 and 0.4 mg calcitriol corresponding to 350% and 280%, respectively, increase compared to the wild type isolate. Among different alginate concentrations applied, immobilization of cell lysate of Actinomyces hyovaginalis isolate using 2% alginate showed 140% increase in calcitriol production from vitamin D3 compared to the free cell lysate. Activity of the immobilized form was preserved for five repetitive uses over a period of 15 days but with a 50% decline in production occurring at the fifth use

Les fractures du zygoma : à propos de 276 cas.

Introduction : les fractures de l’os zygomatique revêtent une multitude de variétés anatomo-cliniques à l’origine de retentissement fonctionnel et morphologique. Le but de ce travail est de déterminer et de préciser les circonstances de survenue, la sémiologie clinique et radiologique, l’attitude thérapeutique et le devenir à moyen terme de ces patients.Patients et méthodes : une étude rétrospective a été menée sur des patients ayant présenté une fracture isolée de l’os zygomatique traités au service de chirurgie maxillo-faciale et chirurgie Plastique de l’hôpital militaire d’instruction mohammed V rabat, entre mars 1999 et avril 2009.Résultats : on a inclu 276 dossiers, l’âge moyen des patients a été de 32 ans avec une nette prédominance masculine (89,5%). Les étiologies ont été dominées par les accidents de la voie publique (64,2%). Le diagnostic a été surtout clinique, confirmé par la radiologie. La réduction ouverte a été effectuée dans 173 cas tandis que 31,9% des cas ont nécessité une réduction fermée. Les séquelles les plus fréquentes ont été représentées par les troubles de la sensibilité (19,2%).Conclusion : l’évaluation pré-opératoire doit inclure une évaluation ophtalmologique complète. Les principes chirurgicaux impliqués dans la gestion des fractures du zygoma sont principalement liées à la réduction. Cette expérience valide certaines indications pour la réduction orthopédique et souligne l’intérêt de la réduction sanglante avec fixation par mini plaques visées. L’indication chirurgicale dépend du type de fracture.Objective : Zygomatic bone fractures have many varieties anatomoclinic at the origin of functional impact. The purpose of this work is to determine and to specify arising circumstances, clinical and radiological epidemiology, therapeutic attitude, and become it of these patients in average term.Patients et méthodes : a retrospective study included patients with zygomatic bone fracture, addmitted at facial surgery department of military Hospital and mohammed V Instruction, rabat; between March 1999 and April 2009.Results: We included 276 files, the average age was 32 years old, with male predominance (89,5%). Causes were dominated by the traffic public accidents (64,2 %). Diagnosis is especially clinic, confirmed by radiology. The open reduction was carried out in 173 cases, while 31,9 % of cases necessitate a closed reduction; the most frequent sequels were sensory troubles (19,2 %).Conclusion : Pre-operative evaluation must include a complete ophtalmological evaluation. Surgical principles in zygoma fractures management are principally linked to the reeducation. This experience validates some indications for orthopedic reeducation, and underlines the interest of bloody reeducation with fixing by aimed mini veneers. Surgical indication depends on fracture typ