10 research outputs found
PAPEL DA ENFERMAGEM NO ATENDIMENTO ĂS MULHERES EM SITUAĂĂO DE VIOLĂNCIA SEXUAL
Introdução: a violĂȘncia sexual contra a mulher tornou-se um problema de SaĂșde PĂșblica, devido as consequĂȘncias fĂsicas e biopsicossociais geradas Ă vĂtima. No Brasil, 14,3% das mulheres jĂĄ sofreram pelo menos um episĂłdio de violĂȘncia sexual na vida. Assim, Ă© vital que os profissionais de saĂșde, dentre eles o Enfermeiro, estejam capacitados para um atendimento humanizado para essa mulher. Objetivo: relatar sobre o papel desempenhado pelo enfermeiro no atendimento frente Ă s vĂtimas de violĂȘncia sexual. MĂ©todo: uma revisĂŁo bibliogrĂĄfica realizada nas bases de dados cientĂficas BVS e SciELO, pelo cruzamento dos seguintes Descritores de CiĂȘncia em SaĂșde: ViolĂȘncia sexual, ViolĂȘncia contra mulher, Enfermagem e AssistĂȘncia Ambulatorial. Os critĂ©rios de inclusĂŁo foram artigos completos, publicados entre 2014 e 2018 e de domĂnio pĂșblico. No entanto, foram excluĂdos os artigos duplicados. Foram encontrados 14 artigos nas bases de dados, mas seguindo os critĂ©rios de exclusĂŁo e inclusĂŁo, restaram apenas 7 produçÔes. Resultados: o enfermeiro deve assumir o compromisso de efetivar o combate Ă violĂȘncia, acolher, estabelecer um vĂnculo de confiança e dar todas as orientaçÔes necessĂĄrias para garantir uma melhor qualidade do atendimento, sendo importante que o enfermeiro possa identificar ou descobrir os casos de violĂȘncia ao investigar aspectos emocionais e caracterĂsticas fĂsicas. ConclusĂŁo: torna-se imprescindĂvel a atuação de enfermeiros capacitados para atenderem as mulheres vĂtimas de violĂȘncia sexual a partir do acolhimento, e por intermĂ©dio de uma escuta qualificada, se estabeleçam intervençÔes adequadas de acordo com a necessidade de cada usuĂĄria, permitindo ofertar uma assistĂȘncia efetiva
Phoneutria toxin PnTx3-5 inhibits TRPV1 channel with antinociceptive action in an orofacial pain model.
Capsaicin, an agonist of TRPV1, evokes intracellular [Ca2+] transients and glutamate release from perfused trigeminal ganglion. The spider toxin PnTx3-5, native or recombinant is more potent than the selective TRPV1 blocker SB-366791 with IC50 of 47???0.18?nM, 45???1.18?nM and 390???5.1?nM in the same experimental conditions. PnTx3-5 is thus more potent than the selective TRPV1 blocker SB-366791. PnTx3-5 (40?nM) and SB-366791 (3??M) also inhibited the capsaicin-induced increase in intracellular Ca2+ in HEK293?cells transfected with TRPV1 by 75???16% and 84???3.2%, respectively. In HEK293?cells transfected with TRPA1, cinnamaldehyde (30??M) generated an increase in intracellular Ca2+ that was blocked by the TRPA1 antagonist HC-030031 (10??M, 89% inhibition), but not by PnTx3-5 (40?nM), indicating selectivity of the toxin for TRPV1. In whole-cell patch-clamp experiments on HEK293?cells transfected with TRPV1, capsaicin (10??M) generated inward currents that were blocked by SB-366791 and by both native and recombinant PnTx3-5 by 47???1.4%; 54???7.8% and 56???9.0%, respectively. Intradermal injection of capsaicin into the rat left vibrissa induced nociceptive behavior that was blocked by pre-injection with either SB-366791 (3 nmol/site i.d., 83.3???7.2% inhibition) or PnTx3-5 (100 fmol/site, 89???8.4% inhibition). We conclude that both native and recombinant PnTx3-5 are potent TRPV1 receptor antagonists with antinociceptive action on pain behavior evoked by capsaicin
Intestinal paracoccidioidomycosis resembling Crohnâs disease in a teenager: a case report
The Genus <i>Miconia</i> Ruiz & Pav. (Melastomataceae): Ethnomedicinal Uses, Pharmacology, and Phytochemistry
Species of the genus Miconia are used in traditional medicine for the treatment of diseases, such as pain, throat infections, fever, and cold, and they used as depuratives, diuretics, and sedatives. This work reviewed studies carried out with Miconia species, highlighting its ethnomedicinal uses and pharmacological and phytochemical potential. This information was collected in the main platforms of scientific research (PubMed, Scopus, and Web of Science). Our findings show that some of the traditional uses of Miconia are corroborated by biological and/or pharmacological assays, which demonstrated, among other properties, anti-inflammatory, analgesic, antimutagenic, antiparasitic, antioxidant, cytotoxic, and antimicrobial activities. A total of 148 chemical compounds were identified in Miconia species, with phenolic compounds being the main constituents found in the species of this genus. Such phytochemical investigations have demonstrated the potential of species belonging to this genus as a source of bioactive substances, thus reinforcing their medicinal and pharmacological importance
Serviço social : questĂŁo social, territĂłrio e polĂtica social
Cassab, Maria Aparecida Tardin , Batistoni, Maria Rosangela - PrefĂĄcio;Duriguetto, Maria LĂșcia , Iamamoto, Marilda Villela - Apresentação.-