Relief for the Curriculum. Architecture Education and Disaster Recovery

This is the final version of the article. It first appeared from University of Cambridge

Post Disaster Housing in Bamboo

In November 2013, one of the biggest tropical storms in history hit the Philippines, the second most vulnerable country in its exposure to natural hazards according to the World Risk Report 2014. A team from the group Natural Materials and Structures from Cambridge University, that researches low cost constructive systems, designed an emergency housing unit for the region of Roxas, affected by the typhoon. The project received a prize at the international competition Versus: Lessons from Vernacular Heritage to Sustainable Architecture (Valencia, September 2014)

Biofilm-forming capability of highly virulent, multidrug-resistant Candida auris

The emerging multidrug-resistant yeast pathogen Candida auris has attracted considerable attention as a source of healthcare–associated infections. We report that this highly virulent yeast has the capacity to form antifungal resistant biofilms sensitive to the disinfectant chlorhexidine in vitro

Living on the move, dwelling between temporality and permanence in Syria

Abstract: Although the international displacement of people caused by the Syrian conflict has dominated the media for the past several years, an inside story that is less visible requires more attention: that of internal displacement. More than half of the population of Syria has been forced to flee their houses. Internally displaced persons (IDPs) in December 2017 accounted for more than six and a half million, more than a third of the total of population of Syria in 2011 (Internal Displacement Monitoring Centre (IDMC), 2012. http://www.internal-displacement.org/middle-east-and-north-africa/syria/). Displaced Syrians have experienced constraints in getting adequate housing for the short- and mid-term inside and outside the country. However, internal displacement, in particular, adds a dimension to the complex notion of mass sheltering. Sheltering policies, or lack thereof, as well as the shelter itself as a design and construction product all express the power of those who govern more than the aspirations of those who inhabit. Affected groups find solutions by themselves, via national or international organisations, or a combination of both. However, such solutions function under the influence of authorities controlling the area in which IDPs are received. Among the alternatives available to displaced communities, this paper reviews two cases of internally displaced families in Syria: a collective centre in government-controlled Damascus (schools) and a planned camp in Afes village in a rebel-held area near Idlib

A Prospective Surveillance Study of Candidaemia : Epidemiology, Risk Factors, Antifungal Treatment and Outcome in Hospitalized Patients

Funding This work was supported by the Wellcome Trust Strategic Award for Medical Mycology and Fungal Immunology 097377/Z/11/Z. Data collection was supported by a grant from Pfizer. GR was also supported by a research fellowship grant from Gilead Sciences. The collection of the isolates was funded by a Gilead Fellowship to GR. Acknowledgments We are grateful to microbiology colleagues throughout Scotland for submitting isolates. Antimicrobial sensitivity testing was performed by the Mycology Reference Laboratory, Public Health England, Bristol.Peer reviewedPublisher PD

Bahay Kawayan. A Transitional House for the Philippines

Colour, 61 pages.The book shows in detail the design and construction process of a transitional bamboo house for the Philippines, a country that was affected, in 2013, by Typhoon Haiyan, the strongest typhoon ever recorded. The low-cost structure is based on the traditional Filipino house, the Bahay Kubo, and was designed to explore a resilient solution for imminent hazards. Moreover, the design could be adapted to any tropical climate where large bamboo grows, considering the local building techniques.AngloAmerican Foundation Grou

The symmetry spectrum in a hybridising, tropical group of rhododendrons

Many diverse plant clades possess bilaterally symmetrical flowers and specialised pollination syndromes, suggesting that these traits may promote diversification. We examined the evolution of diverse floral morphologies in a species‐rich tropical radiation of Rhododendron. We used restriction‐site associated DNA sequencing on 114 taxa from Rhododendron sect. Schistanthe to reconstruct phylogenetic relationships and examine hybridisation. We then captured and quantified floral variation using geometric morphometric analyses, which we interpreted in a phylogenetic context. We uncovered phylogenetic conflict and uncertainty caused by introgression within and between clades. Morphometric analyses revealed flower symmetry to be a morphological continuum without clear transitions between radial and bilateral symmetry. Tropical Rhododendron species that began diversifying into New Guinea c. 6 million years ago expanded into novel floral morphological space. Our results showed that the evolution of tropical Rhododendron is characterised by recent speciation, recurrent hybridisation and the origin of floral novelty. Floral variation evolved via changes to multiple components of the corolla that are only recognised in geometric morphometrics with both front and side views of flowers

Development of a quality of life questionnaire for patients with pancreatic neuroendocrine tumours (the PANNET module)

Gastrinoma; Insulinoma; Pancreatic neuroendocrine tumourGastrinoma; Insulinoma; Tumor neuroendocrino pancreáticoGastrinoma; Insulinoma; Tumor neuroendocrí pancreàticPancreatic neuroendocrine tumours (panNET) are heterogeneous neoplasms usually characterised by slow growth and secretion of hormones, which often cause symptoms. The effect of these symptoms on quality of life (QoL) has not previously been examined in detail. EORTC (European Organisation for Research and Treatment of Cancer) guidelines were followed in phases 1–3 to produce a potential module of questions usable for trials in panNET, focusing on three common types of panNET. For two less common types, a list of symptoms was constructed. Following an extensive literature search and phase 1a interviews with patients and healthcare workers, a long list of potential issues (169) was obtained. This list was shown to 12 patients from three countries in phase 1b interviews to check that no items were missed. The list was reduced to 57 issues. The list of issues was converted to questions, mainly from existing validated questions within the EORTC item library. The list of questions was then used in a phase 3 international study in eight countries using seven languages. A provisional module of 24 items is presented for use in nonfunctioning panNET, gastrinoma and insulinoma. This module increases knowledge concerning QoL in this condition and may be a useful adjunct in clinical trials. A phase 4 trial is being considered for validation of this questionnaire

Essential role for proteinase-activated receptor-2 in arthritis

Using physiological, pharmacological, and gene disruption approaches, we demonstrate that proteinase-activated receptor-2 (PAR-2) plays a pivotal role in mediating chronic inflammation. Using an adjuvant monoarthritis model of chronic inflammation, joint swelling was substantially inhibited in PAR-2-deficient mice, being reduced by more than fourfold compared with wild-type mice, with virtually no histological evidence of joint damage. Mice heterozygous for PAR-2 gene disruption showed an intermediate phenotype. PAR-2 expression, normally limited to endothelial cells in small arterioles, was substantially upregulated 2 weeks after induction of inflammation, both in synovium and in other periarticular tissues. PAR-2 agonists showed potent proinflammatory effects as intra-articular injection of ASKH95, a novel synthetic PAR-2 agonist, induced prolonged joint swelling and synovial hyperemia. Given the absence of the chronic inflammatory response in the PAR-2-deficient mice, our findings demonstrate a key role for PAR-2 in mediating chronic inflammation, thereby identifying a novel and important therapeutic target for the management of chronic inflammatory diseases such as rheumatoid arthritis