Survival Rates and Cause-Specific Mortality of Mule Deer in South-Central Oregon

It is critical for wildlife managers to understand the population dynamics of a harvested species, particularly for ungulates, which are a valuable wildlife resource. Due to concerns that mule deer (Odocoileus hemionus) populations in Oregon were declining, more comprehensive data on population vital rates and the factors potentially affecting them were needed by resource managers. To meet this research need, Oregon Department of Fish and Wildlife implemented a seven year study to investigate habitat use and survival of mule deer in eastern Oregon. From 2005-2012, the agency radiocollared 621 mule deer in south-central Oregon in order to gain more comprehensive information about seasonal movement, seasonal and annual survival, and changes in habitat use for the population. I used the radio-telemetry data from this larger study to investigate mule deer survival rates and cause-specific mortality and the effects of deer seasonal distributions, movement behavior, and environmental factors such as annual and climatic variation. I used known-fate data for 408 adult female radio-collared mule deer to estimate monthly survival rates and to investigate a variety of factors that might affect these rates including seasonal distribution, temporal effects (seasonal, annual, and trends across season and year), movement behavior, and climatic covariates on differing scales. Variation in survival rates for this population of female mule deer in eastern Oregon was best explained by an additive effect of migration behavior, fall migration period, and precipitation levels on individual winter ranges. Survival was significantly higher for migratory deer than residents. Both groups had lower survival during the fall migration period (Oct-Nov) and a positive linear relationship between survival and winter precipitation in individual winter ranges. Annual survival estimates for migrants ranged from 0.81-0.82, which is similar to other findings, but survival rates for residents (0.76- 0.77) were low in comparison to survival rates for adult female mule deer in other parts of their range. I used a nonparametric cumulative incidence function estimator (NPCIFE) to generate annual cumulative incidence functions separately for males and females due to differing risks associated with each sex. The four competing sources of mortality I included in this analysis for males were legal harvest, illegal harvest, predation, and starvation, disease, vehicle or fence-collision combined as one category (i.e., other). For females in investigated predation, human-associated mortality (vehicle or fence), illegal harvest, and natural causes (starvation and disease). Annual risk functions were pooled across all years of the study to maximize sample size. For males, the cumulative risk was highest for legal harvest (0.249, 95%CI=0.172-0.326), with predation the next highest cause of mortality for this sex (0.104, 95%CI=0.042-0.611). For females, the cumulative risk was highest for predation, (0.044, 95%CI=0.028-0.065) with anthropogenic causes (0.038, 95%CI=0.021-0.054) and illegal harvest (0.031, 95%CI=0.17-0.054) also important sources of mortality. Higher monthly survival rates of migrants compared to residents (across all months of the biological cycle) suggested that leaving for potentially higher quality summer foraging grounds outweighed the cost of traveling through unfamiliar habitats and energy expenditure from migration. Conversely, it may also imply that the summer ranges for residents had a negative effect on survival due to habitat quality or human disturbance. Both migrants and residents had lower monthly survival during the fall migration period (Oct - Nov). Female mule deer were excluded from the state-managed bow and rifle hunting season during this study, but females may experience the negative effects of human disturbance associated with fall hunting activities. This time of year is also energetically costly for females, being that some may still be nursing, which could have an additive effect to the energy used to migrate or avoid human disturbance. Winter precipitation also had positive effect on survival for both groups, possibly because increased average winter precipitation resulted in increased winter forage quantity and quality. My results suggest that female survival rates observed during my study are on the low end of the range reported for this species and may be contributing to population declines of mule deer in Oregon. Annual estimates of male survival were also low, but it is unclear how that might contribute to overall population declines without more information on annual and seasonal variation in male survival. Surprisingly, I observed high levels of illegal harvest on female deer and evidence that female survival during the fall migration period, which overlaps Oregon’s legal harvest season, was lower than other times of the year. It is unclear why the fall migration period negatively affects both migrants and resident deer similarly, but future research should attempt to determine the specific factors that are negatively impacting mule deer survival during this time period in south-central Oregon. In addition, as human development in the area continues to grow, it is important to consider migration paths and the habitat quality of both summer and winter ranges. My results suggested that conditions may differ between summer ranges in particular, for residents vs. migrants, and understanding these differences may be the key to increasing survival of female mule deer in Oregon. Sharing information from this study with law enforcement and the general public may be the first step towards increasing awareness of, and thereby reducing, the relatively high levels of illegal harvest I documented for the female population. Future research should focus on investigating the differences in habitat quality for residents versus migrants, the factors that decrease survival during fall migration for both groups, and the social and economic factors that contribute to the illegal harvest of female mule deer in eastern Oregon

The Art and Science of Immunosuppression: The Fifth Annual American Society of Transplant Surgeon's State-of-the-Art Winter Symposium

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/72057/1/j.1600-6143.2005.01187.x.pd

Perceived outcomes of periacetabular osteotomy

Aims: Social media is a popular resource for patients seeking medical information and sharing experiences. periacetabular osteotomy (PAO) is the gold-standard treatment for symptomatic acetabular dysplasia with good long-term outcomes. However, little is known regarding the perceived outcomes of PAO on social media. The aims of this study were to describe the perceived outcomes following PAO using three social media platforms: Facebook, Instagram, and X (formerly known as Twitter). Methods: Facebook, Instagram, and X posts were retrospectively collected from 1 February 2023. Facebook posts were collected from the two most populated interest groups: “periacetabular osteotomy” and “PAO Australia.” Instagram and X posts were queried using the most popular hashtags: #PAOwarrior, #periacetabularosteotomy, #periacetabularosteotomyrecovery, #PAOsurgery, and #PAOrecovery. Posts were assessed for demographic data (sex, race, location), perspective (patient, physician, professional organization, industry), timing (preoperative vs postoperative), and perceived outcome (positive, negative, neutral). Results: A total of 1,054 Facebook posts, 1,003 Instagram posts, and 502 X posts were consecutively assessed from 887 unique authors. The majority (63.3%) of these posts were from patients in the postoperative period, with a median of 84 days postoperatively (interquartile range 20 to 275). The longest follow-up timeframe postoperatively was 20 years. Regarding perceived outcomes, 52.8% expressed satisfaction, 39.7% held neutral opinions, and 7.5% were dissatisfied. Most dissatisfied patients (50.9%) reported pain (chronic or uncontrolled acute) as an attributing factor. Conclusion: Most PAO-perceived surgical outcomes on social media had a positive tone. Findings also indicate that a small percentage of patients reported negative perceived outcomes. However, dissatisfaction with PAO primarily stemmed from postoperative pain. Social media posts from other sources (physicians, hospitals, professional organizations, etc.) trend towards neutrality. Healthcare providers must consider the social media narratives of patients following PAO, as they may reveal additional outcome expectations and help improve patient-centred care, create informed decision-making, and optimize treatment outcomes

Clinical Best Practice Advice for Hepatology and Liver Transplant Providers During the COVID‐19 Pandemic: AASLD Expert Panel Consensus Statement

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/156235/2/hep31281.pdfhttp://deepblue.lib.umich.edu/bitstream/2027.42/156235/1/hep31281_am.pd

PROTOCOL: In‐person interventions to reduce social isolation and loneliness: An evidence and gap map

Abstract This is the protocol for an evidence and gap map. The objectives are as follows: This EGM aims to map available evidence on the effects of in‐person interventions to reduce social isolation and/or loneliness across all age groups in all settings

Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers

Peer reviewedPublisher PD

Hypervirulent Clostridium difficile PCR-Ribotypes Exhibit Resistance to Widely Used Disinfectants

The increased prevalence of Clostridium difficile infection (CDI) has coincided with enhanced transmissibility and severity of disease, which is often linked to two distinct clonal lineages designated PCR-ribotype 027 and 017 responsible for CDI outbreaks in the USA, Europe and Asia. We assessed sporulation and susceptibility of three PCR-ribotypes; 012, 017 and 027 to four classes of disinfectants; chlorine releasing agents (CRAs), peroxygens, quaternary ammonium compounds (QAC) and biguanides. The 017 PCR-ribotype, showed the highest sporulation frequency under these test conditions. The oxidizing biocides and CRAs were the most efficacious in decontamination of C. difficile vegetative cells and spores, the efficacy of the CRAs were concentration dependent irrespective of PCR-ribotype. However, there were differences observed in the susceptibility of the PCR-ribotypes, independent of the concentrations tested for Virkon®, Newgenn®, Proceine 40® and Hibiscrub®. Whereas, for Steri7® and Biocleanse® the difference observed between the disinfectants were dependent on both PCR-ribotype and concentration. The oxidizing agent Perasafe® was consistently efficacious across all three PCR ribotypes at varying concentrations; with a consistent five Log10 reduction in spore titre. The PCR-ribotype and concentration dependent differences in the efficacy of the disinfectants in this study indicate that disinfectant choice is a factor for llimiting the survival and transmission of C. difficile spores in healthcare settings

Peer review quality and transparency of the peer-review process in open access and subscription journals

BACKGROUND:Recent controversies highlighting substandard peer review in Open Access (OA) and traditional (subscription) journals have increased the need for authors, funders, publishers, and institutions to assure quality of peer-review in academic journals. I propose that transparency of the peer-review process may be seen as an indicator of the quality of peer-review, and develop and validate a tool enabling different stakeholders to assess transparency of the peer-review process. METHODS AND FINDINGS:Based on editorial guidelines and best practices, I developed a 14-item tool to rate transparency of the peer-review process on the basis of journals' websites. In Study 1, a random sample of 231 authors of papers in 92 subscription journals in different fields rated transparency of the journals that published their work. Authors' ratings of the transparency were positively associated with quality of the peer-review process but unrelated to journal's impact factors. In Study 2, 20 experts on OA publishing assessed the transparency of established (non-OA) journals, OA journals categorized as being published by potential predatory publishers, and journals from the Directory of Open Access Journals (DOAJ). Results show high reliability across items (α = .91) and sufficient reliability across raters. Ratings differentiated the three types of journals well. In Study 3, academic librarians rated a random sample of 140 DOAJ journals and another 54 journals that had received a hoax paper written by Bohannon to test peer-review quality. Journals with higher transparency ratings were less likely to accept the flawed paper and showed higher impact as measured by the h5 index from Google Scholar. CONCLUSIONS:The tool to assess transparency of the peer-review process at academic journals shows promising reliability and validity. The transparency of the peer-review process can be seen as an indicator of peer-review quality allowing the tool to be used to predict academic quality in new journals

In‐person interventions to reduce social isolation and loneliness: An evidence and gap map

BackgroundSocial isolation and loneliness can occur in all age groups, and they are linked to increased mortality and poorer health outcomes. There is a growing body of research indicating inconsistent findings on the effectiveness of interventions aiming to alleviate social isolation and loneliness. Hence the need to facilitate the discoverability of research on these interventions.ObjectivesTo map available evidence on the effects of in-person interventions aimed at mitigating social isolation and/or loneliness across all age groups and settings.Search MethodsThe following databases were searched from inception up to 17 February 2022 with no language restrictions: Ovid MEDLINE, Embase, EBM Reviews—Cochrane Central Register of Controlled Trials, APA PsycInfo via Ovid, CINAHL via EBSCO, EBSCO (all databases except CINAHL), Global Index Medicus, ProQuest (all databases), ProQuest ERIC, Web of Science, Korean Citation Index, Russian Science Citation Index, and SciELO Citation Index via Clarivate, and Elsevier Scopus.Selection CriteriaTitles, abstracts, and full texts of potentially eligible articles identified were screened independently by two reviewers for inclusion following the outlined eligibility criteria.Data Collection and AnalysisWe developed and pilot tested a data extraction code set in Eppi-Reviewer. Data was individually extracted and coded. We used the AMSTAR2 tool to assess the quality of reviews. However, the quality of the primary studies was not assessed.Main ResultsA total of 513 articles (421 primary studies and 92 systematic reviews) were included in this evidence and gap map which assessed the effectiveness of in-person interventions to reduce social isolation and loneliness. Most (68%) of the reviews were classified as critically low quality, while less than 5% were classified as high or moderate quality. Most reviews looked at interpersonal delivery and community-based delivery interventions, especially interventions for changing cognition led by a health professional and group activities, respectively. Loneliness, wellbeing, and depression/anxiety were the most assessed outcomes. Most research was conducted in high-income countries, concentrated in the United States, United Kingdom, and Australia, with none from low-income countries. Major gaps were identified in societal level and community-based delivery interventions that address policies and community structures, respectively. Less than 5% of included reviews assessed process indicators or implementation outcomes. Similar patterns of evidence and gaps were found in primary studies. All age groups were represented but more reviews and primary studies focused on older adults (≥60 years, 63%) compared to young people (≤24 years, 34%). Two thirds described how at-risk populations were identified and even fewer assessed differences in effect across equity factors for populations experiencing inequities

Evaluation of polygenic risk scores for breast and ovarian cancer risk prediction in BRCA1 and BRCA2 mutation carriers

Background: Genome-wide association studies (GWAS) have identified 94 common single-nucleotide polymorphisms (SNPs) associated with breast cancer (BC) risk and 18 associated with ovarian cancer (OC) risk. Several of these are also associated with risk of BC or OC for women who carry a pathogenic mutation in the high-risk BC and OC genes BRCA1 or BRCA2. The combined effects of these variants on BC or OC risk for BRCA1 and BRCA2 mutation carriers have not yet been assessed while their clinical management could benefit from improved personalized risk estimates. Methods: We constructed polygenic risk scores (PRS) using BC and OC susceptibility SNPs identified through population-based GWAS: for BC (overall, estrogen receptor [ER]-positive, and ER-negative) and for OC. Using data from 15 252 female BRCA1 and 8211 BRCA2 carriers, the association of each PRS with BC or OC risk was evaluated using a weighted cohort approach, with time to diagnosis as the outcome and estimation of the hazard ratios (HRs) per standard deviation increase in the PRS. Results: The PRS for ER-negative BC displayed the strongest association with BC risk in BRCA1 carriers (HR = 1.27, 95% confidence interval [CI] = 1.23 to 1.31, P = 8.2 x 10(53)). In BRCA2 carriers, the strongest association with BC risk was seen for the overall BC PRS (HR = 1.22, 95% CI = 1.17 to 1.28, P = 7.2 x 10(-20)). The OC PRS was strongly associated with OC risk for both BRCA1 and BRCA2 carriers. These translate to differences in absolute risks (more than 10% in each case) between the top and bottom deciles of the PRS distribution; for example, the OC risk was 6% by age 80 years for BRCA2 carriers at the 10th percentile of the OC PRS compared with 19% risk for those at the 90th percentile of PRS. Conclusions: BC and OC PRS are predictive of cancer risk in BRCA1 and BRCA2 carriers. Incorporation of the PRS into risk prediction models has promise to better inform decisions on cancer risk management