326 research outputs found
Walking the Talk in Bullying Prevention: Teacher Implementation Variables Related to Initial Impact of the \u27Steps to Respect\u27 Program
This study examined relationships between teacher implementation of a comprehensive bullying prevention program and student outcomes. Implementation in third- through sixth-grade classrooms (N = 36) was measured by observation and teacher report. Student outcomes were measured by student surveys and teacher ratings of peer social skills (N = 549) and observations of playground behaviors (n = 298). Multilevel modeling showed that teacher coaching of students involved in bullying was associated with less observed victimization and destructive bystander behavior among students engaged in these problems at pretest, and less observed aggression among ïŹfth- and sixth-grade students. Support for skill generalization related to reductions in observed aggression and victimization among older students. Adherence to lessons was associated with higher ratings of peer social skills. Quality of lesson instruction corresponded to greater self-reported victimization, as well as more perceived difïŹculty responding assertively to bullying. Implications for school-based practice and future research directions are discussed
"A Lot of People Are Struggling Privately. They Donât Know Where to Go or Theyâre Not Sure of What to Doâ : Frontline Service Provider Perspectives of the Nature of Household Food Insecurity in Scotland
Funding: This research was funded by NHS Health Scotland with additional funding support provided for Flora Douglasâ and Stephen Whybrowâs time from the Scottish Governmentâs RESAS programme. Core support to HERU from the Chief Scientist Office Scottish Government Health and Social Care Directorates and the University of Aberdeen is gratefully acknowledged. Acknowledgments: We would like to acknowledge Bill Gray and Dionne MacKinnon (BG NHS Health Scotland and DMcK, formerly of NHS Health Scotland) for their professional review and support during the project and our study participants for their time and expertise. We are also grateful to the anonymous reviewers of our paper for their time and extremely helpful contributions to this work.Peer reviewedPublisher PD
Reducing Playground Bullying and Supporting Beliefs: An Experimental Trial of the \u27Steps to Respect\u27 Program
Six schools were randomly assigned to a multilevel bullying intervention or a control condition. Children in Grades 3â6 (N = 1,023) completed pre- and posttest surveys of behaviors and beliefs and were rated by teachers. Observers coded playground behavior of a random subsample (n = 544). Hierarchical analyses of changes in playground behavior revealed declines in bullying and argumentative behavior among intervention-group children relative to control-group children, increases in agreeable interactions, and a trend toward reduced destructive bystander behavior. Those in the intervention group reported enhanced bystander responsibility, greater perceived adult responsiveness, and less acceptance of bullying/aggression than those in the control group. Self-reported aggression did not differ between the groups. Implications for future research on the development and prevention of bullying are discussed
Effect of a Pre-Dinner Walnut Snack on Nutrient Intake Among University Students
https://openriver.winona.edu/urc2018/1021/thumbnail.jp
Mindfulness-based school interventions: A systematic review of outcome evidence quality by study design.
Objective: The purpose of this systematic review was to assess the current literature on mindfulness-based school interventions (MBSIs) by evaluating evidence across specific outcomes for youth.
Methods: We evaluated 77 studies with a total sample of 12,358 students across five continents, assessing the quality of each study through a robust coding system for evidence-based guidelines. Coders rated each study numerically per study design as 1++ (RCT with a very low risk of bias) to 4 (expert opinion) and across studies for the corresponding evidence letter grade, from highest quality (\u27A Grade\u27) to lowest quality (\u27D Grade\u27) evidence.
Results: The highest quality evidence (\u27A Grade\u27) across outcomes indicated that MBSIs increased prosocial behavior, resilience, executive function, attention and mindfulness, and decreased anxiety, attention problems/ADHD behaviors and conduct behaviors. The highest quality evidence for well-being was split, with some studies showing increased well-being and some showing no improvements. The highest quality evidence suggests MBSIs have a null effect on depression symptoms.
Conclusion: This review demonstrates the promise of incorporating mindfulness interventions in school settings for improving certain youth outcomes. We urge researchers interested in MBSIs to study their effectiveness using more rigorous designs (e.g., RCTs with active control groups, multi-method outcome assessment, and follow-up evaluation), to minimize bias and promote higher quality-not just increased quantity-evidence that can be relied upon to guide school-based practice
Mindfulness-Based School Interventions: a Systematic Review of Outcome Evidence Quality by Study Design
OBJECTIVE: The purpose of this systematic review was to assess the current literature on mindfulness-based school interventions (MBSIs) by evaluating evidence across specific outcomes for youth. METHODS: We evaluated 77 studies with a total sample of 12,358 students across five continents, assessing the quality of each study through a robust coding system for evidence-based guidelines. Coders rated each study numerically per study design as 1++ (RCT with a very low risk of bias) to 4 (expert opinion) and across studies for the corresponding evidence letter grade, from highest quality (âA Gradeâ) to lowest quality (âD Gradeâ) evidence. RESULTS: The highest quality evidence (âA Gradeâ) across outcomes indicated that MBSIs increased prosocial behavior, resilience, executive function, attention and mindfulness, and decreased anxiety, attention problems/ADHD behaviors and conduct behaviors. The highest quality evidence for well-being was split, with some studies showing increased well-being and some showing no improvements. The highest quality evidence suggests MBSIs have a null effect on depression symptoms. CONCLUSION: This review demonstrates the promise of incorporating mindfulness interventions in school settings for improving certain youth outcomes. We urge researchers interested in MBSIs to study their effectiveness using more rigorous designs (e.g., RCTs with active control groups, multi-method outcome assessment, and follow-up evaluation), to minimize bias and promote higher qualityânot just increased quantityâevidence that can be relied upon to guide school-based practice
Sporopollenin exine capsules (SpECs) derived from Lycopodium clavatum provide practical antioxidant properties by retarding rancidification of an Ï-3 oil
In recent years the use of natural antioxidants in foodstuffs and personal care products has become increasingly important for consumers and therefore manufacturers. In this work, sporopollenin exine capsules (SpECs), extracted from spores of the common club moss Lycopodium clavatum L, have been shown to protect an Ï-3 oil from oxidation caused by natural light or accelerated oxidation with UV irradiation. The mechanism of action has been shown to be principally by free radical quenching as opposed to light shielding, supported by evidence of similarity in levels of protection when the ratio of SpECs to oil was 0.2 % w/v compared with 50 % w/w. The antioxidant effect is not materially altered by the extraction process from the raw material and is clearly an inherent property of the sporopollenin contained in the spores of L. clavatum due to the accessible phenolic groups on the surface on the SpECs. These results provide promising evidence that SpECs could be useful as a bio-sourced antioxidant for protecting Ï-3 oils and related oxidation-prone molecules
Threonine 149 Phosphorylation Enhances  ÎFosB Transcriptional Activity to Control Psychomotor Responses to Cocaine
Stable changes in neuronal gene expression have been studied as mediators of addicted states. Of particular interest is the transcription factor ÎFosB, a truncated and stable FosB gene product whose expression in nucleus accumbens (NAc), a key reward region, is induced by chronic exposure to virtually all drugs of abuse and regulates their psychomotor and rewarding effects. Phosphorylation at Ser[superscript 27] contributes to ÎFosB's stability and accumulation following repeated exposure to drugs, and our recent work demonstrates that the protein kinase CaMKIIα phosphorylates ÎFosB at Ser[superscript 27] and regulates its stability in vivo. Here, we identify two additional sites on ÎFosB that are phosphorylated in vitro by CaMKIIα, Thr[superscript 149] and Thr[superscript 180], and demonstrate their regulation in vivo by chronic cocaine. We show that phosphomimetic mutation of Thr[superscript 149] (T149D) dramatically increases AP-1 transcriptional activity while alanine mutation does not affect transcriptional activity when compared with wild-type (WT) ÎFosB. Using in vivo viral-mediated gene transfer of ÎFosB-T149D or ÎFosB-T149A in mouse NAc, we determined that overexpression of ÎFosB-T149D in NAc leads to greater locomotor activity in response to an initial low dose of cocaine than does WT ÎFosB, while overexpression of ÎFosB-T149A does not produce the psychomotor sensitization to chronic low-dose cocaine seen after overexpression of WT ÎFosB and abrogates the sensitization seen in control animals at higher cocaine doses. We further demonstrate that mutation of Thr[superscript 149] does not affect the stability of ÎFosB overexpressed in mouse NAc, suggesting that the behavioral effects of these mutations are driven by their altered transcriptional properties
Influencing tumor-associated macrophages in malignant melanoma with monoclonal antibodies
The application of monoclonal antibodies (mAbs) for the treatment of melanoma has significantly improved the clinical management of this malignancy over the last decade. Currently approved mAbs for melanoma enhance T cell effector immune responses by blocking immune checkpoint molecules PD-L1/PD-1 and CTLA-4. However, more than half of patients do not benefit from treatment. Targeting the prominent myeloid compartment within the tumor microenvironment, and in particular the ever-abundant tumor-associated macrophages (TAMs), may be a promising strategy to complement existing therapies and enhance treatment success. TAMs are a highly diverse and plastic subset of cells whose pro-tumor properties can support melanoma growth, angiogenesis and invasion. Understanding of their diversity, plasticity and multifaceted roles in cancer forms the basis for new promising TAM-centered treatment strategies. There are multiple mechanisms by which macrophages can be targeted with antibodies in a therapeutic setting, including by depletion, inhibition of specific pro-tumor properties, differential polarization to pro-inflammatory states and enhancement of antitumor immune functions. Here, we discuss TAMs in melanoma, their interactions with checkpoint inhibitor antibodies and emerging mAbs targeting different aspects of TAM biology and their potential to be translated to the clinic
DNM1 encephalopathy: A new disease of vesicle fission.
ObjectiveTo evaluate the phenotypic spectrum caused by mutations in dynamin 1 (DNM1), encoding the presynaptic protein DNM1, and to investigate possible genotype-phenotype correlations and predicted functional consequences based on structural modeling.MethodsWe reviewed phenotypic data of 21 patients (7 previously published) with DNM1 mutations. We compared mutation data to known functional data and undertook biomolecular modeling to assess the effect of the mutations on protein function.ResultsWe identified 19 patients with de novo mutations in DNM1 and a sibling pair who had an inherited mutation from a mosaic parent. Seven patients (33.3%) carried the recurrent p.Arg237Trp mutation. A common phenotype emerged that included severe to profound intellectual disability and muscular hypotonia in all patients and an epilepsy characterized by infantile spasms in 16 of 21 patients, frequently evolving into Lennox-Gastaut syndrome. Two patients had profound global developmental delay without seizures. In addition, we describe a single patient with normal development before the onset of a catastrophic epilepsy, consistent with febrile infection-related epilepsy syndrome at 4 years. All mutations cluster within the GTPase or middle domains, and structural modeling and existing functional data suggest a dominant-negative effect on DMN1 function.ConclusionsThe phenotypic spectrum of DNM1-related encephalopathy is relatively homogeneous, in contrast to many other genetic epilepsies. Up to one-third of patients carry the recurrent p.Arg237Trp variant, which is now one of the most common recurrent variants in epileptic encephalopathies identified to date. Given the predicted dominant-negative mechanism of this mutation, this variant presents a prime target for therapeutic intervention
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