Primary diffuse large B-cell lymphoma of the oral cavity Linfoma difuso de grandes células B primário de boca

Lymphomas arising within the oral cavity account for only 3.5% of all oral malignancies. Diffuse large B-cell lymphoma is a non-Hodgkin lymphoma subtype characterized by diffuse proliferation of large neoplastic B lymphoid cells. This paper reports a case of diffuse large B-cell lymphoma affecting the oral cavity of a Brazilian woman, along with its clinical, microscopical, immunohistochemical, and molecular features.Linfomas correspondem a 3,5% de todos os casos de lesões malignas de boca. O linfoma difuso de grandes células B é um subtipo de linfoma não-Hodgkin caracterizado pela proliferação difusa de células linfóides B. Este artigo relata um caso de linfoma difuso de grandes células B localizado na cavidade bucal de uma mulher brasileira, incluindo os achados clínicos, microscópicos, imuno-histoquímicos e moleculares

Human papillomavirus (HPV) genotype distribution in penile carcinoma: Association with clinic pathological factors

<div><p>Background</p><p>Penile carcinoma (PC) is a rare, highly mutilating disease, common in developing countries. The evolution of penile cancer includes at least two independent carcinogenic pathways, related or unrelated to HPV infection.</p><p>Objectives</p><p>To estimate the prevalence, identify HPV genotypes, and correlate with clinicopathological data on penile cancer.</p><p>Methods</p><p>A retrospective cohort study involving 183 patients with PC undergoing treatment in a referral hospital in Goiânia, Goiás, in Midwestern Brazil, from 2003 to 2015. Samples containing paraffin embedded tumor fragments were subjected to detection and genotyping by INNO-LiPA HPV. The clinicopathological variables were subjected to analysis with respect to HPV positivity and used prevalence ratio (PR), adjusted prevalence ratio (PRa) and 95% confidence interval (CI) as statistical measures.</p><p>Results</p><p>The prevalence of HPV DNA in PC was 30.6% (95% CI: 24.4 to 37.6), high-risk HPV 24.9% (95% CI: 18.9 to 31.3), and 62.5% were HPV 16. There was a statistical association between the endpoints HPV infection and HPV high risk, and the variable tumor grade II-III (p = 0.025) (p = 0.040), respectively. There was no statistical difference in disease specific survival at 10 years between the HPV positive and negative patients (p = 0.143), and high and low risk HPV (p = 0.325).</p><p>Conclusions</p><p>The prevalence of HPV infection was 30.6%, and 80.3% of the genotypes were identified as preventable by anti-HPV quadrivalent or nonavalent vaccine. HPV infections and high-risk HPV were not associated with penile carcinoma prognosis in this study.</p></div

Prevalence of HPV-DNA in 183 cases of penile carcinoma in a referral hospital in Goias, Brazil.

<p>Prevalence of HPV-DNA in 183 cases of penile carcinoma in a referral hospital in Goias, Brazil.</p

Bivariate and multivariate analysis of factors associated with infection by high-risk HPV.

<p>Bivariate and multivariate analysis of factors associated with infection by high-risk HPV.</p

Descriptive analysis of clinical variables in patients with penile carcinoma in Goiania, Goias, Brazil.

<p>Descriptive analysis of clinical variables in patients with penile carcinoma in Goiania, Goias, Brazil.</p

HPV genotype distribution in a population with PC.

<p>HR: High risk; LR: Low risk.</p

Curve of survival of patients positive and negative for HPV.

<p>Curve of survival of patients positive and negative for HPV.</p