Enforcement of Employment Protection and the hiring behaviour of firms. Evidence from a large Italian region.

This paper investigates the effect of the Employment Protection Legislation (EPL) on the hiring behaviour of the firms when the level of EPL is differentiated by firms size. In this respect, Italy represents an interesting case because workers hired by bigger firms enjoy a stronger protection than workers hired by small firms; the threshold size is fixed by law at 15 employees. A model derives the conditions under which firms decide whether to upsize or not and, in case of upsizing, whether to hire temporary (i.e. workers who are not counted in the threshold, as apprentices in Italy) or permanent workers. The model has been tested using data drawn from the VWH (Veneto Workers History) registered data for firms and workers, from 1982 to 1997, for a large Italian region (i.e. Veneto). Firms close to the threshold are not scared to growth but they are more likely to hire apprentices than permanent workers.Employment Protection, Hiring, Random Effects, Regression Discontinuity Design.

Job Security and New Restrictive Permanent Contracts. Are Spanish Workers More Worried of Losing Their Job?

This paper investigates the impact of the introduction of new restrictive permanent contracts on the perceived job security of the workers in Spain. The perceived job security is strongly influenced by the characteristics of individuals and their distribution within groups. Comparing heterogeneous groups could make the traditional DID estimator biased. To address this issue I combine the propensity score matching DID with a fixed effect estimator. The analysis is conducted using data from the ECHP Survey for Spain from 1995 to 2000. The result is that this reform has a positive impact only for one targeted group, i.e. the young workers and no effect for the others. Several robustness checks are performed.Job security, Firing Costs, Evaluation Policy, Fixed effect estimator.

Early Retirement and Financial Incentives: Differences Between High and Low Wage Earners

This paper investigates the impact of financial incentives on early-retirement behaviour for high and low wage earners. Using a stylized life-cycle model, we derive hypotheses on the behaviour of the two types. We use administrative data and employ two identification strategies to test the predictions. First, we exploit exogenous variation in the replacement rate over birth cohorts of workers who are eligible to a transitional early retirement scheme. Second, we employ a regression discontinuity design by comparing workers who are eligible and non-eligible to the transitional scheme. The empirical results show that low wage earners are, as predicted by the model, more sensitive to financial incentives. The results imply that low wage earners will experience a stronger incentive to continue working in an optimal early retirement scheme.

Job Mobility and Skill Transferability. Some Evidences from Denmark and a Large Italian Region

This paper investigates the effect of job mobility and tenure on wage dynamics. In this respect, theory assesses that high job mobility and low tenure are associated to lower wage drop when workers experience a job change. We test this theory first comparing two labour market (i.e. Denmark and a large Italian region, Veneto) characterized by different job mobility and tenure, as a consequence of different level of EPL. Secondly, we perform a within Veneto analysis, comparing the different effects when workers are employed in small rather than big firms. Data drawn from the VWH (Veneto Workers History) and IDA (for Denmark) registered data, from 1987 to 2001, are used. In Denmark job mobility has a positive effect on wage increases, while built up on firm-specific human capital has a negative effect. In Veneto, instead, it appears that long tenure are more rewarding. Some evidences of positive impact of moving from job to job when the barriers are lower come from the analysis of the differences between small and big firms in Veneto.Information sale, Cheap talk, Conflicts of interest, Information Acquisition, Firewalls, Market efficiency

The Mediterranean Diet in the Prevention of Degenerative Chronic Diseases

Degenerative chronic diseases are a problem related to the aging phenomenon of industrialized countries due to the increase of risk factors and related comorbidity such as overweight, obesity, metabolic syndrome, diabetes, hypertension and hyperlipidemia with a consequent increased risk of cardiovascular disease (CVD) and cancer. Moreover, the significant reduction of physical activity in daily life and the huge growth in food availability have considerably increased the risk of such diseases. Particular attention should be paid to primary prevention by means of health strategies based on improvement in lifestyle intervention such as implementation of Mediterranean diet and promotion of physical activity programs. In this chapter, the protective effect of Mediterranean diet and the role of certain foods and/or their constituents are analyzed; the possible mechanisms by which Mediterranean diet is effective in the prevention of cardiovascular and other chronic diseases are presented, in particular the effects exerted by antioxidants, polyphenols, fibers, unsaturated fatty acids, and alcohol. The genetic revolution in the past decades has produced new fields of study where the interaction between foods, nutrients, and our genetic makeup is investigated. The relationship between nutrigenetics and nutrigenomics and the Mediterranean diet are the future area that research should discover

Fast blood impedance measurements as quality indicators in the pre-analytical phase to prevent laboratory errors

In clinical laboratories, the major proportion of errors regarding blood analyses occurs in the pre-analytical phase. Pre-analytical conditions are key, necessary factors in maintaining the high quality of specimens, limiting day-to-day and batch variations, and guaranteeing the absolute reliability and accuracy of clinical results and related diagnoses. The quality of serum samples must be very high in order to avoid interferences due to hemolysis, thereby preventing measurement errors. In addition, the quality of the blood should always be fast monitored to identify inadequacies and guarantee their complete usability in transfusion procedures. In the near future, the solution could be to supply laboratories with smart and portable devices that are able to perform fast quality tests for every sample. Electrical impedance has relevant potential in analyzing and monitoring blood quality. We propose a new, simple impedancebased biosensor that can perform accurate and efficient single and multi-frequency impedance measurements in the pre-analytical phase and to check the quality of blood samples using quantitative thresholds as useful indicators to ensure the reliability of results and thereby prevent laboratory errors. The proposed sensor allows for discriminating different blood components, identifying hemolysis in serum, evaluating blood quality, and rapidly quantifying its hematocrit

Flooding Responses on Grapevine: A Physiological, Transcriptional, and Metabolic Perspective

Studies on model plants have shown that temporary soil flooding exposes roots to a significant hypoxic stress resulting in metabolic re-programming, accumulation of toxic metabolites and hormonal imbalance. To date, physiological and transcriptional responses to flooding in grapevine are poorly characterized. To fill this gap, we aimed to gain insights into the transcriptional and metabolic changes induced by flooding on grapevine roots (K5BB rootstocks), on which cv Sauvignon blanc (Vitis vinifera L.) plants were grafted. A preliminary experiment under hydroponic conditions enabled the identification of transiently and steadily regulated hypoxia-responsive marker genes and drafting a model for response to oxygen deprivation in grapevine roots. Afterward, over two consecutive vegetative seasons, flooding was imposed to potted vines during the late dormancy period, to mimick the most frequent waterlogging events occurring in the field. Untargeted transcriptomic and metabolic profiling approaches were applied to investigate early responses of grapevine roots during exposure to hypoxia and subsequent recovery after stress removal. The initial hypoxic response was marked by a significant increase of the hypoxia-inducible metabolites ethanol, GABA, succinic acid and alanine which remained high also 1 week after recovery from flooding with the exception of ethanol that leveled off. Transcriptomic data supported the metabolic changes by indicating a substantial rearrangement of primary metabolic pathways through enhancement of the glycolytic and fermentative enzymes and of a subset of enzymes involved in the TCA cycle. GO and KEGG pathway analyses of differentially expressed genes showed a general down-regulation of brassinosteroid, auxin and gibberellin biosynthesis in waterlogged plants, suggesting a general inhibition of root growth and lateral expansion. During recovery, transcriptional activation of gibberellin biosynthetic genes and down-regulation of the metabolic ones may support a role for gibberellins in signaling grapevine rootstocks waterlogging metabolic and hormonal changes to the above ground plant. The significant internode elongation measured upon budbreak during recovery in plants that had experienced flooding supported this hypothesis. Overall integration of these data enabled us to draft a first comprehensive view of the molecular and metabolic pathways involved in grapevine\u2019s root responses highlighting a deep metabolic and transcriptomic reprogramming during and after exposure to waterlogging

A new method for accurate platelet thrombi volume measurement using a confocal microscope

The accuracy of quantitative measurements represents an essential pre-requisite to the characterization and definition of the complex dynamic phenomena occurring in the field of cell biology. In research projects that involve the induction of blood coagulation under flow in microfluidic artificial channels, thrombus volume is an important quantity for estimation as a significant index related to the individual thrombotic risk profile. Concerning its importance in the early diagnosis of cardiovascular diseases, the estimated thrombus volume should reflect and represent reality. In 3D confocal microscopy, systematic errors can arise from distortions of the axial distance, whose accurate calibration remains a challenge. As a result, the 3D reconstructions show a noticeable axial elongation, and the volume measurements are thus overestimated. In this paper, a 400-600 % volume overestimation is demonstrated, and a new easy to use and automatic calibration procedure is outlined for this specific microfluidic and optical context. The adaptive algorithm proposed leads to the automatic compensation of the elongation error and to the accurate thrombus volume measurement. The method has been calibrated using fluorescent beads of known volume, validated with groups of several distinct platelets and finally applied on platelet thrombi

Functional foods and cardiometabolic diseases: International Task Force for Prevention of Cardiometabolic Diseases.

Mounting evidence supports the hypothesis that functional foods containing physiologically-active components may be healthful. Longitudinal cohort studies have shown that some food classes and dietary patterns are beneficial in primary prevention, and this has led to the identification of putative functional foods. This field, however, is at its very beginning, and additional research is necessary to substantiate the potential health benefit of foods for which the diet-health relationships are not yet scientifically validated. It appears essential, however, that before health claims are made for particular foods, in vivo randomized, double-blind, placebo-controlled trials of clinical end-points are necessary to establish clinical efficacy. Since there is need for research work aimed at devising personalized diet based on genetic make-up, it seems more than reasonable the latter be modeled, at present, on the Mediterranean diet, given the large body of evidence of its healthful effects. The Mediterranean diet is a nutritional model whose origins go back to the traditional diet adopted in European countries bordering the Mediterranean sea, namely central and southern Italy, Greece and Spain; these populations have a lower incidence of cardiovascular diseases than the North American ones, whose diet is characterized by high intake of animal fat. The meeting in Naples and this document both aim to focus on the changes in time in these two different models of dietary habits and their fall out on public health