Family History and Breast Cancer Hormone Receptor Status in a Spanish Cohort

Breast cancer is a heterogenous disease that impacts racial/ethnic groups differently. Differences in genetic composition, lifestyles, reproductive factors, or environmental exposures may contribute to the differential presentation of breast cancer among Hispanic women.A population-based study was conducted in the city of Santiago de Compostela, Spain. A total of 645 women diagnosed with operable invasive breast cancer between 1992 and 2005 participated in the study. Data on demographics, breast cancer risk factors, and clinico-pathological characteristics of the tumors were collected. Hormone receptor negative tumors were compared with hormone receptor postive tumors on their clinico-pathological characteristics as well as risk factor profiles.Among the 645 breast cancer patients, 78% were estrogen receptor-positive (ER+) or progesterone receptor-positive (PR+), and 22% were ER−&PR−. Women with a family history of breast cancer were more likely to have ER−&PR− tumors than women without a family history (Odds ratio, 1.43; 95% confidence interval, 0.91–2.26). This association was limited to cancers diagnosed before age 50 (Odds ratio, 2.79; 95% confidence interval, 1.34–5.81).An increased proportion of ER−&PR− breast cancer was observed among younger Spanish women with a family history of the disease

Clinicopathological, Karyometric, and Immunohistochemical Characteristics of Breast Cancer Cases and by ER and PR status.

1<p>Ps for categorical variables were estimated from χ² tests. P for the comparison of median ages was esimated from Wilcoxon Rank-Sum test and Ps for other continuous variables were estimated from t-tests.</p>2<p>Histology, lymph node metastasis, grade, MIB1, P53 expression and DNA ploidy index, were unknown for 2, 7, 106, 121, 230 and 1 cases, respectively.</p>3<p>Data on nuclear are, perimeter and DNA shape were available for only 353 cases.</p>4<p>Mean ±standard deviation.</p

Clinicopathological, karyometric, and immunohistochemical characteristics of breast cancer by family history.

1<p>Ps for categorical variables were estimated from χ² tests. P for the comparison of median ages was esimated from Wilcoxon Rank-Sum test and Ps for other continuous variables were estimated from t-tests.</p>2<p>Histology, lymph node metastasis, grade, MIB1, P53 expression and DNA ploidy index were unknown for 11, 48, 2, 7, 106, 121, 230 and 1 cases, respectively.</p>3<p>Data on nuclear are, perimeter and DNA shape were available for only 353 cases.</p>4<p>Mean ±standard deviation.</p

Association between select breast cancer risk factors and hormone receptor status.

1<p>Results were estimated from case-only logistic regressions with adjustment for age at diagnosis.</p

Family history and breast cancer hormone receptor status by age at diagnosis.

1<p>Subjects with missing information of ER, PR, or family history were removed from analyses.</p>2<p>Results were estimated from case-only logistic regressions with adjustment for age at diagnosis.</p

Family history and breast cancer subtypes further stratified by DNA ploidy.

1<p>Subjects with missing information of ER, PR, or family history were removed from analyses.</p>2<p>Results were estimated from case-only logistic regressions with adjustment for age at diagnosis.</p