Analytical model for gravitational-wave echoes from spinning remnants

Gravitational-wave echoes in the postmerger signal of a binary coalescence are predicted in various scenarios, including near-horizon quantum structures, exotic states of matter in ultracompact stars, and certain deviations from general relativity. The amplitude and frequency of each echo is modulated by the photon-sphere barrier of the remnant, which acts as a spin- and frequency-dependent high-pass filter, decreasing the frequency content of each subsequent echo. Furthermore, a major fraction of the energy of the echo signal is contained in low-frequency resonances corresponding to the quasinormal modes of the remnant. Motivated by these features, in this work we provide an analytical gravitational-wave template in the low-frequency approximation describing the postmerger ringdown and the echo signal of a spinning ultracompact object. Besides the standard ringdown parameters, the template is parametrized in terms of only two physical quantities: the reflectivity coefficient and the compactness of the remnant. We discuss novel effects related to the spin and to the complex reflectivity, such as a more involved modulation of subsequent echoes, the mixing of two polarizations, and the ergoregion instability in the case of perfectly reflecting spinning remnants. Finally, we compute the errors in the estimation of the template parameters with current and future gravitational-wave detectors using a Fisher matrix framework. Our analysis suggests that models with almost perfect reflectivity can be excluded/detected with current instruments, whereas probing values of the reflectivity smaller than 80% at the 3σ confidence level requires future detectors (Einstein Telescope, Cosmic Explorer, LISA). The template developed in this work can easily be implemented to perform a matched-filter based search for echoes and to constrain models of exotic compact objects

Governing with urban big data in the smart city environment: an italian perspective

A smart city is more than its mere technological components. From a legal standpoint, smartness means a civic-enabling regulatory environment, access to technological resources, and openness to the political decision-making process. No doubt, the core asset of this socio-technical revolution is the data generated within the urban contest. However, national and EU law does not provide a specific regulation for using this data. Indeed, the next EU data strategy, with the open data and non-personal data legislation and the forthcoming Data Act, aims to promote a more profitable use of urban and local big data. Nonetheless, at present, this latter still misses a consistent approach to this issue. A thorough understanding of the smart city requires, first of all, the reconceptualization of big data in terms of urban data. Existing definitions and studies about this topic converge on the metropolises of East Asia and, sometimes, the USA. Instead, we approach the issues experienced in medium-size cities, focusing on the main Italian ones. Especially in this specific urban environment, data can help provide better services, automatize administrations, and further democratization only if they are understood holistically - as urban data. Cities, moreover, are a comprehensive source of data themselves, both collected from citizens and urban things. Among the various types of data that can be gathered, surveillance recordings play a crucial role. On the one hand, video surveillance is essential for many purposes, such as protecting public property, monitoring traffic, controlling high-security risk areas, and preventing crime and vandalism. From another standpoint, these systems can be invasive towards citizens' rights and freedoms: in this regard, urban data collected from video surveillance systems may be shared with public administrations or other interested entities, only afterward they have been anonymized. Even this process needs to be aligned with the transparency and participation values that inform the city's democracy. Thus, the anonymization process must be fully compliant with data protection legislation, looking for the most appropriate legal basis and assessing all the possible sources of risks to the rights and freedoms of people (DPIA). Urban data, indeed, is a matter of local democracy. The availability of data and the economy of platforms can significantly transform a city's services and geography as well as citizens' lifestyles. However, the participation of citizens to express their views on both the use of urban data for public policy and the regulation of the digital economy is still a challenge. The paper aims to analyze the projects of some Italian cities - including Milan, Rome, and Turin - which have tried to introduce participatory urban data management tools and to highlight the possible challenges of a democratic management of service platforms and data transfer for social and economic development

Increased levels of interleukin-6 exacerbate the dystrophic phenotype in mdx mice

Duchenne muscular dystrophy (DMD) is characterized by progressive lethal muscle degeneration and chronic inflammatory response. The mdx mouse strain has served as the animal model for human DMD. However, while DMD patients undergo extensive necrosis, the affected muscles of adult mdx mice rapidly regenerates and regains structural and functional integrity. The basis for the mild effects observed in mice compared with the lethal consequences in humans remains unknown. In this study, we provide evidence that interleukin-6 (IL-6) is causally linked to the pathogenesis of muscular dystrophy. We report that forced expression of IL-6, in the adult mdx mice, recapitulates the severe phenotypic characteristics of DMD in humans. Increased levels of IL-6 exacerbate the dystrophic muscle phenotype, sustaining inflammatory response and repeated cycles of muscle degeneration and regeneration, leading to exhaustion of satellite cells. The mdx/IL6 mouse closely approximates the human disease and more faithfully recapitulates the disease progression in humans. This study promises to significantly advance our understanding of the pathogenic mechanisms that lead to DMD

Analytical model for gravitational-wave echoes from spinning remnants

Gravitational-wave echoes in the postmerger signal of a binary coalescence are predicted in various scenarios, including near-horizon quantum structures, exotic states of matter in ultracompact stars, and certain deviations from general relativity. The amplitude and frequency of each echo is modulated by the photon-sphere barrier of the remnant, which acts as a spin- and frequency-dependent high-pass filter, decreasing the frequency content of each subsequent echo. Furthermore, a major fraction of the energy of the echo signal is contained in low-frequency resonances corresponding to the quasinormal modes of the remnant. Motivated by these features, in this work we provide an analytical gravitational-wave template in the low-frequency approximation describing the postmerger ringdown and the echo signal of a spinning ultracompact object. Besides the standard ringdown parameters, the template is parametrized in terms of only two physical quantities: the reflectivity coefficient and the compactness of the remnant. We discuss novel effects related to the spin and to the complex reflectivity, such as a more involved modulation of subsequent echoes, the mixing of two polarizations, and the ergoregion instability in the case of perfectly reflecting spinning remnants. Finally, we compute the errors in the estimation of the template parameters with current and future gravitational-wave detectors using a Fisher matrix framework. Our analysis suggests that models with almost perfect reflectivity can be excluded/detected with current instruments, whereas probing values of the reflectivity smaller than 80% at the 3σ confidence level requires future detectors (Einstein Telescope, Cosmic Explorer, LISA). The template developed in this work can easily be implemented to perform a matched-filter based search for echoes and to constrain models of exotic compact objects

Catalytic Dehydration of Fructose to 5-Hydroxymethylfurfural in Aqueous Medium over Nb2O5-Based Catalysts

The catalytic dehydration of fructose to 5-hydroxymethylfurfural (HMF) in water was performed in the presence of pristine Nb2O5 and composites containing Nb and Ti, Ce or Zr oxides. In all experiments, fructose was converted to HMF using water as the solvent. The catalysts were characterized by powder X-ray diffraction, scanning electron microscopy, N2 physical adsorption, infrared and Raman spectroscopy and temperature-programmed desorption of NH3. Experimental parameters such as fructose initial concentration, volume of the reacting suspension, operation temperature, reaction time and amount of catalyst were tuned in order to optimize the catalytic reaction process. The highest selectivity to HMF was ca. 80% in the presence of 0.5 g\ub7L 121 of bare Nb2O5, Nb2O5-TiO2 or Nb2O5-CeO2 with a maximum fructose conversion of ca. 70%. However, the best compromise between high conversion and high selectivity was reached by using 1 g\ub7L 121 of pristine Nb2O5. Indeed, the best result was obtained in the presence of Nb2O5, with a fructose conversion of 76% and a selectivity to HMF of 75%, corresponding to the highest HMF yield (57%). This result was obtained at a temperature of 165\ub0 in an autoclave after three hours of reaction by using 6 mL of 1 M fructose suspension with a catalyst amount equal to 1 g\ub7L 121

Chronic Intestinal Disorders in Humans and Pets: Current Management and the Potential of Nutraceutical Antioxidants as Alternatives

Chronic intestinal disorders (CID) are characterized by persistent, or recurrent gastrointestinal (GI) signs present for at least three weeks. In human medicine, inflammatory bowel disease (IBD) is a group of chronic GI diseases and includes Crohn’s disease (CD) and ulcerative colitis (UC). On the other hand, the general term chronic enteropathies (CE) is preferred in veterinary medicine. Different therapeutic approaches to these diseases are used in both humans and pets. This review is focused on the use of traditional therapies and nutraceuticals with specific antioxidant properties, for the treatment of CID in humans and animal patients. There is strong evidence of the antioxidant properties of the nutraceuticals included in this review, but few studies report their use for treating CID in humans and none in animals. Despite this fact, the majority of the nutraceuticals described in the present article could be considered as promising alternatives for the regular treatment of CID in human and veterinary medicine

Suitability of electroencephalography in brain death determination: a monocentric, 10-year retrospective, observational investigation of 428 cases

Background We aimed to verify the usefulness of electroencephalographic (EEG) activity recording (that is mandatory according to the Italian law), in addition to two clinical evaluations spaced 6 h, among the procedures of brain death determination (BDD) in adult individuals. Methods The study is a monocentric, retrospective analysis of all BDDs performed in the last 10 years at Policlinico Le Scotte in Siena (Italy). Results Of the 428 cases revised (mean age 67.6 ± 15.03 years; range 24–92 years), 225 were males and 203 females. In total, 212 out of 428 patients (49.5%) were donors. None of the BDD procedures were interrupted due to the reappearance of EEG activity (neither for clinical reasons) at any sampling time, with the exception of one case that was considered a false negative at critical reinspection of the EEG. In 6/428 cases (1.4%), a cardiac arrest occurred during the 6 h between the first and second evaluation, thus missing the opportunity to take organs from these patients because the BDD procedure was not completed. Conclusions Once the initial clinical examination before convening the BDD Commission has ascertained the absence of brainstem reflexes and of spontaneous breathing, and these clinical findings are supported by a flat EEG recording, the repetition of a 30-min EEG twice over a 6 h period seems not to add additional useful information to clinical findings. Current data, if confirmed in other centers and possibly in prospective studies, may help to promote a scientific and bioethical debate in Italy, as well as in other countries where the EEG is still mandatory, for eventually pdating the procedures of BDD. © 2022, The Author(s)