1,883 research outputs found
The development of microbicides: A new method of HIV prevention for women
A critical review of current epidemiological trends and social science research demonstrates that there is an urgent need for expanding the range of female-controlled HIV prevention methods. Existing efforts to control the spread of HIV infection primarily through the encouragement of a reduction in the number of sexual partners, widespread condom promotion, and the control of other sexually transmitted infections are inadequate for many of the world\u27s women. Underlying gender power inequities severely limit the ability of many women to protect themselves from HIV infection, especially in the absence of a prevention technology they can use, when necessary, without their partner\u27s consent. Current understanding of biology suggests that developing such methods is a feasible and potentially cost-effective endeavor. This paper describes the growing risk of HIV infection faced by women throughout the world, examines the limitation of contemporary AIDS prevention strategy in meeting the needs of women, reviews the existing data on female-controlled HIV prevention methods, and outlines the challenges for future microbicide development
Homocysteine, Folate, and Vitamins B\u3csub\u3e6\u3c/sub\u3e and B\u3csub\u3e12\u3c/sub\u3e Blood Levels in Relation to Cognitive Performance: The Maine-Syracuse Study
Objective: Our objective was to examine associations among plasma homocysteine concentrations (tHcy), the tHcy-cofactors (folate, vitamins B6 and B12), and multiple domains of cognitive performance, with statistical adjustment for possible confounds, including cardiovascular disease risk factors (CVD-RF) and cardiovascular disease (CVD). Methods: Subjects were 812 partici- pants (58% women) of the Maine-Syracuse study who were free of dementia and stroke. Employing a cross-sectional design and multiple regression analyses, fasting concentrations of tHcy and its vitamin cofactors (folate, B6, and B12) were related to multiple domains of cognitive performance. Results: With adjustment for age, education, gender, ethnicity, and the vitamins, tHcy was inversely associated with visual-spatial organization, working memory, scanning-tracking, and abstract reasoning. The same results were found with adjustment for age, education, gender, ethnicity, CVD-RF, and CVD. Vitamin cofactors were positively related to cognitive performance, but with adjustment for CVD-RF and CVD, only vitamin B6 was related to multiple cognitive domains. Conclusions: The inverse association of tHcy with multiple domains of cognitive functioning is not necessarily dependent on vitamin levels, vitamin deficiency, prevalent CVD risk factors, and manifest CVD. Serum folate, serum B12, and plasma B6 vitamin concentrations are positively associated with cognitive performance. Investigation of other possible mechanisms (e.g., tHcy neurotoxicity) mediating tHcy associations with cognitive performance is important, as are clinical trials examining the efficacy of folate, vitamin B6, and vitamin B12 for maintenance of cognitive functioning
Detection of CO and Dust Emission in Near-Infrared Spectra of SN 1998S
Near-infrared spectra (0.95 -- 2.4 micron) of the peculiar Type IIn supernova
1998S in NGC 3877 from 95 to 355 days after maximum light are presented. K-band
data taken at days 95 and 225 show the presence of the first overtone of CO
emission near 2.3 micron, which is gone by day 355. An apparent extended blue
wing on the CO profile in the day 95 spectrum could indicate a large CO
expansion velocity (~2000 -- 3000 km/s). This is the third detection of
infrared CO emission in nearly as many Type II supernovae studied, implying
that molecule formation may be fairly common in Type II events, and that the
early formation of molecules in SN 1987A may be typical rather than
exceptional. Multi-peak hydrogen and helium lines suggest that SN 1998S is
interacting with a circumstellar disk, and the fading of the red side of this
profile with time is suggestive of dust formation in the ejecta, perhaps
induced by CO cooling. Continuum emission that rises towards longer wavelengths
(J -> K) is seen after day 225 with an estimated near-infrared luminosity >~
10^40 erg/s. This may be related to the near-infrared excesses seen in a number
of other supernovae. If this continuum is due to free-free emission, it
requires an exceptionally shallow density profile. On the other hand, the shape
of the continuum is well fit by a 1200 +- 150 K blackbody spectrum possibly due
to thermal emission from dust. Interestingly, we observe a similar 1200 K
blackbody-like, near-infrared continuum in SN 1997ab, another Type IIn
supernova at an even later post-maximum epoch (day 1064+). A number of dust
emission scenarios are discussed, and we conclude that the NIR dust continuum
is likely powered by the interaction of SN 1998S with the circumstellar medium.Comment: 38 Pages, 12 Figures, Submitted to The Astronomical Journa
Functional differences in the microbial processing of recent assimilates under two contrasting perennial bioenergy plantations
Land use change driven alteration of microbial communities can have implications on belowground C cycling and storage, although our understanding of the interactions between plant C inputs and soil microbes is limited. Using phospholipid fatty acids (PLFA's) we profiled the microbial communities under two contrasting UK perennial bioenergy crops, Short Rotation Coppice (SRC) willow and Miscanthus Giganteus (miscanthus), and used 13C â pulse labelling to investigate how recent carbon (C) assimilates were transferred through plant tissues to soil microbes. Total PLFA's and fungal to bacterial (F:B) ratios were higher under SRC willow (Total PLFA = 47.70 ± 1.66 SE ÎŒg PLFA gâ1 dry weight soil, F:B = 0.27 ± 0.01 SE) relative to miscanthus (Total PLFA = 30.89 ± 0.73 SE ÎŒg PLFA gâ1 dry weight soil, F:B = 0.17 ± 0.00 SE). Functional differences in microbial communities were highlighted by contrasting processing of labelled C. SRC willow allocated 44% of total 13C detected into fungal PLFA relative to 9% under miscanthus and 380% more 13C was returned to the atmosphere in soil respiration from SRC willow soil compared to miscanthus. Our findings elucidate the roles that bacteria and fungi play in the turnover of recent plant derived C under these two perennial bioenergy crops, and provide important evidence on the impacts of land use change to bioenergy on microbial community composition
Black Titania and Niobia within Ten Minutes : Mechanochemical Reduction of Metal Oxides with Alkali Metal Hydrides
Partially or fully reduced transition metal oxides
show extraordinary electronic and catalytic properties but are
usually prepared by high temperature reduction reactions.
This study reports the systematic investigation of the fast
mechanochemical reduction of rutile-type TiO2 and H-Nb2O5
to their partially reduced black counterparts applying NaH
and LiH as reducing agents. Milling time and oxide to
reducing agent ratio show a large influence on the final
amount of reduced metal ions in the materials. For both
oxides LiH shows a higher reducing potential than NaH. An
intercalation of Li+ into the structure of the oxides was
proven by PXRD and subsequent Rietveld refinements as well
as 6
Li solid-state NMR spectroscopy. The products showed a
decreased band gap and the presence of unpaired electrons
as observed by EPR spectroscopy, proving the successful
reduction of Ti4+ and Nb5+. Furthermore, the developed
material exhibits a significantly enhanced photocatalytic
performance towards the degradation of methylene blue
compared to the pristine oxides. The presented method is a
general, time efficient and simple method to obtain reduced
transition metal oxides
The Massive Progenitor of the Type II-Linear Supernova 2009kr
We present early-time photometric and spectroscopic observations of supernova (SN) 2009kr in NGC 1832. We find that its properties to date support its classification as Type II-linear (SN II-L), a relatively rare subclass of core-collapse supernovae (SNe). We have also identified a candidate for the SN progenitor star through comparison of pre-explosion, archival images taken with WFPC2 on board the Hubble Space Telescope with SN images obtained using adaptive optics plus NIRC2 on the 10 m Keck-II telescope. Although the host galaxy's substantial distance (similar to 26 Mpc) results in large uncertainties in the relative astrometry, we find that if this candidate is indeed the progenitor, it is a highly luminous (M(V)(0) = -7.8 mag) yellow supergiant with initial mass similar to 18-24 M(circle dot). This would be the first time that an SN II-L progenitor has been directly identified. Its mass may be a bridge between the upper initial mass limit for the more common Type II-plateau SNe and the inferred initial mass estimate for one Type II-narrow SN.Hungarian OTKA K76816NSF AST-0707769, AST-0908886Sylvia & Jim Katzman FoundationTABASGO FoundationNASA through STScI AR-11248, GO-10877Harvard UniversityUC BerkeleyUniversity of VirginiaNASA/Swift NNX09AQ66GDOEAstronom
Extraordinary Late-Time Infrared Emission of Type IIn Supernovae
Near-Infrared (NIR) observations are presented for five Type IIn supernovae
(SN 1995N, SN 1997ab, SN 1998S, SN 1999Z, and SN 1999el) that exhibit strong
infrared excesses at late times (t >= 100 d). H- and K-band emission from these
objects is dominated by a continuum that rises toward longer wavelengths. The
data are interpreted as thermal emission from dust, probably situated in a
pre-existing circumstellar nebula. The IR luminosities implied by single
temperature blackbody fits are quite large,> 10^(41 - 42) erg s^-1, and the
emission evolves slowly, lasting for years after maximum light. For SN 1995N,
the integrated energy release via IR dust emission was 0.5 -- 1 * 10^50 erg. A
number of dust heating scenarios are considered, the most likely being an
infrared echo poweredby X-ray and UV emissions from the shock interaction with
a dense circumstellar medium.Comment: 14 Pages, 3 Figures, Accecpted for publication in The Astrophysical
Journa
Case finding and case management of chlamydia and gonorrhea infections among women: What we do and do not know
As the world grapples with the HIV pandemic, the implementation of the agenda determined by the International Conference on Population and Development (1994) at Cairo, and the matter of providing health services of adequate quality in an ethical, gender-sensitive manner, new questions are arising about how to attend to reproductive tract infections, including sexually transmitted infections (STIs), among women. This paper reviews the results of validation studies of syndromic algorithms, other nonlaboratory clinically based tools, and risk scoring for finding women infected with chlamydia and gonorrhea, particularly among those attending family planning and antenatal clinics in developing countries. The results raise challenges for policymakers in sorting through what course of action is most appropriate in a particular context. Research and policy analysis for determining the best approach for addressing chlamydia/gonorrhea infection in settings with different prevalence rates, program capacity, and sexual behavior patterns are lacking. The report concludes that simple low-cost diagnostics for use in resource-poor settings are desperately needed
A study of women\u27s preferences regarding the formulation of over-the-counter vaginal spermicides
There is an urgent need for safe, effective, and acceptable vaginal barrier methods for the prevention of sexually transmitted diseases (STDs), including HIV, and a variety of existing spermicides have the potential to be used for both prevention of STDs and unwanted pregnancy. Unfortunately, very little is known about formulation preferences and the desirable characteristics of vaginal preparations among the diverse populations of women who would potentially use these products. In this study, we explored vaginal spermicidal preparations containing nonoxynol-9 and the characteristics that influence user preferences for three formulations, as well as the risk of vaginal and cervical irritation associated with low-to-moderate use of products containing nonoxynol-9. The report recommends that formulation preferences of women be considered in the development and introduction of vaginal microbicides: the specific characteristics of vaginal products and their effect on sexual pleasure and communication will strongly determine the acceptabilityâand ultimately the use-effectivenessâof female-controlled STD-prevention methods
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