School-Based Speech-Language Pathologist Collaborative Practice: A Literature Review

Background: School-based speech language pathologists (SLPs) are increasing collaborative engagement with educators and other professionals in school settings. Collaborative practice in the general education classroom increased student’s awareness of literacy concepts. The push-in model of service delivery reached students with varied levels of literacy understanding. There is insufficient empirical evidence regarding school-based interprofessional practice (IPP) available to clinicians. Systemic reviews provide a model for educators and SLPs to follow; many professionals hesitate to engage in IPP because there is a deficiency in evidence of success. Aims: Investigation of the necessary components for successful IPP and the impacts of collaboration on an array of student abilities is explored in this literature review. Contributions: IPP leading to improved literacy comprehension across a range of students was reported through various systematic reviews. Conclusion: Initiating and implementing IPP increases literacy education in the general education classroom and reduces the number of students needing literacy assistance in approaching years. Student’s improved understanding of literacy concepts leads to success in reading, writing, spelling, and communicating. If SLP-teacher collaborative instruction becomes common practice, implications could include improved literacy skills across a spectrum of students and educators efficiently teaching literacy objectives without SLP assistance. Keywords: collaborative, interprofessional practice (IPP), speech-language pathology, response to intervention (RTI), literacy, push-in mode

Alternative Forms for Promotion and Dissemination of Good Management Practices

At the present stage actuality of the problem is predetermined by the needs of the real management practice in organizations and the need to offer theoretical and practical knowledge to enable it methodologically correct and methodically right to implement appropriate changes in the management of the particular organization.The article is devoted to one aspect in the field of management - creating a new form of organization of management (called new favorite) - international managerial architecture. It argues that it was dictated by poor management of institutional and corporate level, the lack of adequate professional standards, control and monitoring of the activities of managers. An attempt is made to give a reasoned response to relatively basic question: "Predetermination or managerial obfuscation are alternative forms of promotion and dissemination of good management practices?". The goal is to answer the question in a relatively unbiased approach, insofar as possible minimizing subjectivity in the treatment of problems. Finally, certain results of the proposed thesis on the need for the creation of NIMA are discussed- structure and structural parameters. The discussions are based on the experience in the Republic of Bulgaria taken as an example situation

Empirical Investigation of Industrial Management

The paper is devoted to an aspect in the sphere of management – business priorities of industrial management in XXI century. In modern times the actuality of treated problems is mainly laid into the necessities of the real management practice in industrial organizations and the need theoretical and applied knowledge to be offered to that practice which would allow it methodologically right and methodically correct to implement the corresponding changes in management of a concrete organization. Objects of analyses and evaluations are some fragmented approbations of theses using the corresponding instruments. The characteristic features of the organizations’ profiles and the persons interviewed participated in the investigation are summarized. The determining approaches for Bulgarian organizations are considered too.On the basis of the critical analyses the fundamental tasks are drawn which are inherent to contemporary industrial managers. Attention is paid to key management functions for an effective managerial process. An analysis of managers reaching the best results in industrial management is presented as well as when they are reached. Outlined are also specific peculiarities of industrial management in theRepublicofBulgariaand parameters of the level of productiveness in conditions of business globalization and priority forms in marketing of the ready product / service in XXI century. The results of the launched idea for the necessity to create a new International management architecture (NIMA) are determined – structure and structure defining parameters. The results of the investigation of main business priorities in industrial management are commented as well as expected problems in the process of functioning of industrial organizations in XXI century. At the end the corresponding conclusions are made in respect to the techniques used in determining effectiveness of industrial management in Bulgarian organizations

Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans

Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in 25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16 regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP, while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium (LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region. Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa, an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent signals within the same regio

Early rare recurrence of a huge renal solitary fibrous tumor: Case report and review of literature

Solitary fibrous tumor (SFT) is a spindle cell neoplasm of mesenchymal origin. First reported in 1931, the pleura is the most common localization of SFT, and it’s exceptionally rare in the kidney. Overall, it represents less than 2% of all soft tissue tumors. In most cases, renal SFT (rSFT) presents with hematuria, flank pain, and a palpable mass. To our knowledge, less than 112 cases of rSFT have been reported. We report a case of rSFT of a 30-year-old male thought to be a renal cell carcinoma (RCC). Radical nephrectomy (RN) was done to remove a large right-sided mass invading the inferior vena cava. Immunohistochemistry confirmed the diagnosis of SFT showing positivity for CD34, CD99, and Bcl-2 protein, with no staining for cytokeratin. A post-operative CT (15 months) showed tumor recurrence in the renal compartment with huge inferior vena cava thrombus extending to the external iliac veins. With this case, we illustrate and highlight the importance of this diagnosis because of the uncertain biological behavior and prognosis of these tumors