Diagnostics and monitoring of economic entities security

The article shows the place and role of economic entities in the system of economic security of territories. Various approaches to the definition of the term “economic security of small businesses” are considered. The main factors and threats to the economic security of economic entities of the territories are presented. Presents the author’s system of basic indicators of estimation of economic safety of economic entities of the territory. Offers on carrying out diagnostics and monitoring of risks are given. Recommendations as a rating of economic security of economic entities of territories are given. The procedure for monitoring the economic security of economic entities of the territories based on a risk-based approach can be represented in the form of five interrelated stages. This is the stage of collecting data on enterprises and the calculation of the necessary indicators. The stage of formation of the system of indicators, they are risk factors. Stage of processing indicators. The stage of building an integrated model of potential and risk assessment. In addition, the final stage of assessment of the complex level of economic security of economic entities of the territories. This will allow making management decisions in the field of development and support of small businesses at the territorial level

Study of dry pellets of blood plasma using THz spectroscopy

This work is devoted to the development of a suitable phantom of a biological object for measurements in the THz frequency range and for approbation with various diagnostic methods developed in different THz laboratories. The phantoms were represented as a pellet of human and a laboratory rat blood plasma in the diabetic and the control groups. These objects were analyzed in various laboratories, using THz pulsed spectroscopy and a high-resolution THz spectrometer based on a backward wave oscillator. The components of the dry blood plasma were identified by the detected spectral lines

Diagnostics and monitoring of economic entities security

The article shows the place and role of economic entities in the system of economic security of territories. Various approaches to the definition of the term “economic security of small businesses” are considered. The main factors and threats to the economic security of economic entities of the territories are presented. Presents the author’s system of basic indicators of estimation of economic safety of economic entities of the territory. Offers on carrying out diagnostics and monitoring of risks are given. Recommendations as a rating of economic security of economic entities of territories are given. The procedure for monitoring the economic security of economic entities of the territories based on a risk-based approach can be represented in the form of five interrelated stages. This is the stage of collecting data on enterprises and the calculation of the necessary indicators. The stage of formation of the system of indicators, they are risk factors. Stage of processing indicators. The stage of building an integrated model of potential and risk assessment. In addition, the final stage of assessment of the complex level of economic security of economic entities of the territories. This will allow making management decisions in the field of development and support of small businesses at the territorial level

Terahertz spectroscopy of diabetic and non-diabetic human blood plasma pellets

Significance: The creation of fundamentally new approaches to storing various biomaterial and estimation parameters, without irreversible loss of any biomaterial, is a pressing challenge in clinical practice. We present a technology for studying samples of diabetic and non-diabetic human blood plasma in the terahertz (THz) frequency range. Aim: The main idea of our study is to propose a method for diagnosis and storing the samples of diabetic and non-diabetic human blood plasma and to study these samples in the THz frequency range. Approach: Venous blood from patients with type 2 diabetes mellitus and conditionally healthy participants was collected. To limit the impact of water in the THz spectra, lyophilization of liquid samples and their pressing into a pellet were performed. These pellets were analyzed using THz time-domain spectroscopy. The differentiation between the THz spectral data was conducted using multivariate statistics to classify non-diabetic and diabetic groups’ spectra. Results:We present the density-normalized absorption and refractive index for diabetic and nondiabetic pellets in the range 0.2 to 1.4 THz. Over the entire THz frequency range, the normalized index of refraction of diabetes pellets exceeds this indicator of non-diabetic pellet on average by 9% to 12%. The non-diabetic and diabetic groups of the THz spectra are spatially separated in the principal component space. Conclusion: We illustrate the potential ability in clinical medicine to construct a predictive rule by supervised learning algorithms after collecting enough experimental data

One-Pot Synthesis of Affordable Redox-Responsive Drug Delivery System Based on Trithiocyanuric Acid Nanoparticles

Redox-responsive drug delivery systems present a promising avenue for drug delivery due to their ability to leverage the unique redox environment within tumor cells. In this work, we describe a facile and cost-effective one-pot synthesis method for a redox-responsive delivery system based on novel trithiocyanuric acid (TTCA) nanoparticles (NPs). We conduct a thorough investigation of the impact of various synthesis parameters on the morphology, stability, and loading capacity of these NPs. The great drug delivery potential of the system is further demonstrated in vitro and in vivo by using doxorubicin as a model drug. The developed TTCA-PEG NPs show great drug delivery efficiency with minimal toxicity on their own both in vivo and in vitro. The simplicity of this synthesis, along with the promising characteristics of TTCA-PEG NPs, paves the way for new opportunities in the further development of redox-responsive drug delivery systems based on TTCA