Томские набережные

The article presents the basic concepts of the project on creation of the zone of advanced economic growth “Tomsk embankments” in Tomsk. Disconnected territories in the center of the city containing a lot of slum houses, industrial, household and warehouse facilities are united through the system of public spaces that opens the city toward the river. A modern and good-quality level of territorial development is provided by reinterpretation of functionality and the use of platforms for formation of “new territories” in the interdam space. The first impression of the city is created by a bright architectural character of landmarks.Раскрываются основные положения концепции проекта «Создание зоны опережающего развития города Томска "Томские набережные"». Разрозненные территории, являющиеся центром города и при этом наполненные большим количеством ветхой застройки, производственных и коммунально-складских объектов с низким уровнем индустриализации, объединяются через создание системы общественных пространств, раскрывающих город к реке. Переосмысление функционального наполнения, применение платформ при формировании «новых территорий» в междамбовом пространстве задает современный качественный уровень развития территорий. Яркий архитектурный образ знаковых объектов формирует первое впечатление о городе

Regulation of the microecological state of the lower parts of the female reproductive tract with vitamins

Aim. To study the changes in the microecology of the vagina under the influence of ascorbic acid, α-tocopherol, and retinol acetate.Materials and methods. The number of vaginal lactobacilli and opportunistic bacteria, the concentrations of IL1β, raIL1, INFγ, TGFβ1, lactoferrin and sIgA in vaginal fluids of women with deficiency of ascorbic acid (n = 35) or retinol acetate (n = 35) or α-tocopherol (n = 35) were assessed before and after intravaginal application of these vitamins. The obtained data were compared with those of healthy women without vitamin deficiency (n = 15).Results. An association between deficiency of α-tocopherol, retinol acetate and ascorbic acid with a deficiency of lactoflora, a high frequency of bacterial vaginosis and candidiasis, and proinflammatory changes of the parameters of mucosal immunity has been found. A normalizing effect of all vitamins on the lactoflora of the vagina was identified. The severity of this effect decreased in the following order: α-tocopherol → retinol acetate → ascorbic acid. Retinol acetate caused the increase, while ascorbate and tocopherol caused the reduction in the number of opportunistic microorganisms. The effect of ascorbate was pronounced, but short-term, while the effect of tocopherol was less pronounced, but long-lasting. The use of vitamins affected the condition of mucosal immunity in different directions: ascorbic acid caused an increase in pro-inflammatory changes; on the contrary, α-tocopherol and retinol acetate caused anti-inflammatory changes.Conclusion. Our data on the effects of α-tocopherol, retinol acetate, and ascorbic acid on the microecological state of the vaginal biotope suggest that these vitamins may be considered as regulatory factors for both host cells and microsymbionts

One-Pot Synthesis of Affordable Redox-Responsive Drug Delivery System Based on Trithiocyanuric Acid Nanoparticles

Redox-responsive drug delivery systems present a promising avenue for drug delivery due to their ability to leverage the unique redox environment within tumor cells. In this work, we describe a facile and cost-effective one-pot synthesis method for a redox-responsive delivery system based on novel trithiocyanuric acid (TTCA) nanoparticles (NPs). We conduct a thorough investigation of the impact of various synthesis parameters on the morphology, stability, and loading capacity of these NPs. The great drug delivery potential of the system is further demonstrated in vitro and in vivo by using doxorubicin as a model drug. The developed TTCA-PEG NPs show great drug delivery efficiency with minimal toxicity on their own both in vivo and in vitro. The simplicity of this synthesis, along with the promising characteristics of TTCA-PEG NPs, paves the way for new opportunities in the further development of redox-responsive drug delivery systems based on TTCA